Article
Medicine, General & Internal
Bradley S. Peterson, Tejal Kaur, Maria Andrea Baez, Ronald C. Whiteman, Siddhant Sawardekar, Juan Sanchez-Pena, Xuejun Hao, Kristin W. Klahr, Ardesheer Talati, Priya Wickramaratne, Myrna M. Weissman, Ravi Bansal
Summary: It is still unclear whether morphological markers of risk for familial depression exist in the hippocampus or amygdala. This study found that individuals at high risk for Major Depressive Disorder (MDD) showed inward deformations of the hippocampi and the medial surface of the left amygdala. The findings suggest that these morphological features may serve as endophenotypic biomarkers for familial MDD.
Article
Biology
Giang H. Nguyen, Sewon Oh, Corey Schneider, Jia Y. Teoh, Maggie Engstrom, Carmen Santana-Gonzalez, David Porter, Karina Quevedo
Summary: This study explores the use of neurofeedback training and positive autobiographical memory retrieval in modulating neural networks involved in emotion regulation and memory recall in adolescents with depression. The results suggest that neurofeedback training can increase activity in the amygdala, hippocampus, and anterior cingulate cortex, and further investigation is needed to determine the optimal dosage of the training for depressed youth.
Article
Clinical Neurology
Bhedita J. Seewoo, Jennifer Rodger, Mark A. Demitrack, Karen L. Heart, John D. Port, Jeffrey R. Strawn, Paul E. Croarkin
Summary: The neurobiology of treatment-resistant depression (TRD) in adolescents and the impact of treatment on this neurobiology is poorly understood. This study found that adolescents with TRD and major depressive disorder (MDD) had reduced amygdala volumes compared to healthy adolescents. However, six weeks of active transcranial magnetic stimulation (TMS) increased amygdala volumes and the volume of the stimulated dorsolateral prefrontal cortex in adolescents with TRD.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Clinical Neurology
Xuejun Jiang, Feng Wu, Yifan Zhang, Huizi Li, Jiahui Kang, Lingtao Kong, Fei Wang, Yanqing Tang
Summary: This study investigated the association between brain function and gender in bipolar disorder using amplitude of low-frequency fluctuations (ALFF). The results indicated gender differences in dysfunction of the cortico-limbic neural system in BD. Male and female patients with BD showed different patterns of ALFF in various brain regions.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Review
Neurosciences
Antonio Del Casale, Stefano Ferracuti, Andrea Steven Barbetti, Paride Bargagna, Paolo Zega, Alessia Iannuccelli, Federico Caggese, Teodolinda Zoppi, Gabriele Pasquale De Luca, Giovanna Parmigiani, Isabella Berardelli, Maurizio Pompili
Summary: In this meta-analysis, researchers investigated the grey matter changes in patients with posttraumatic stress disorder (PTSD) compared to trauma-exposed individuals without clinical PTSD. The results showed a significant reduction in grey matter volume in a large left-sided cluster extending from the parahippocampal gyrus to the uncus, including the amygdala, in PTSD patients. These findings suggest that these volumetric reductions may be a major structural correlate of PTSD and contribute to symptom expression.
NEUROPSYCHOBIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xunrong Luo, Qingfa Ren, Mingfang Luo, Tianping Li, Yijie Lv, Yan Liu, Kang Rong, Wei Zhang, Xianglin Li
Summary: This study investigated changes in GluCEST value in the hippocampus of rats exposed to chronic unpredictable mild stress, and explored the impact of these changes on the activity of hippocampal glutamatergic neurons. The study found significant correlations between GluCEST values and ALFF as well as ReHo values. The GluCEST technique has the potential to map glutamate changes in rat depression and glutamate neurotransmitters are crucial in affecting abnormal neural activity.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)
Article
Endocrinology & Metabolism
Mats Holmberg, Helge Malmgren, Rolf A. Heckemann, Birgitta Johansson, Niklas Klasson, Erik Olsson, Simon Skau, Goran Starck, Helena Filipsson Nystrom
Summary: The study found that Graves disease (GD) affects regional medial temporal lobe (MTL) volumes, with patients having smaller MTL regions compared to controls before treatment, and increased volumes in MTL regions after treatment. There were significant correlations between thyrotropin receptor antibodies (TRAb) levels and MTL volumes, as well as between free 3,5,3'-triiodothyronine levels and TRAb levels with MTL volumes. However, there were no significant correlations between symptoms or test scores and MTL volumes.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Neurosciences
Ranchao Wang, Yu Shen, Guohai Li, Rui Du, Aiqin Peng
Summary: This study established a predictive model for treatment response in depression based on short-term changes in hippocampal metabolites and validated its accuracy using a separate dataset.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Clinical Neurology
Fabiano G. Nery, Jeffrey A. Welge, David Fleck, Wade Weber, Rodrigo Patino, Jeffrey R. Strawn, Caleb M. Adler, Stephen M. Strakowski, Melissa P. DelBello
Summary: To identify biomarkers of prodromal mood disorders, functional brain activation was examined in children and adolescents at familial risk for bipolar disorder. It was found that at-risk youth exhibited reduced activation to emotional distracters in the right ventrolateral prefrontal cortex at baseline. Additionally, increased activation in the right ventrolateral prefrontal cortex, caudate, and putamen at baseline predicted the development of a mood episode in at-risk youth who later experienced such an episode.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Li Liang, Ling-Ling Wang, Xiao-Dong Jiang, Dong-Jian Chen, Tian-An Huang, Wen-Bin Ding
Summary: This study investigated changes in hippocampal structure and resting-state functional connectivity (FC) in patients with depression in Parkinson disease (DPD). The results showed that the volume of bilateral hippocampi in patients with DPD was significantly decreased and negatively correlated with the severity of depressive disorder. The weakened FC of the right hippocampus to the right occipital lobe and the left precuneus may play an important role in the neurological basis of DPD.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2023)
Article
Neurosciences
Rachel Corr, Sarah Glier, Joshua Bizzell, Andrea Pelletier-Baldelli, Alana Campbell, Candace Killian-Farrell, Aysenil Belger
Summary: Early life stress exposures are related to adverse health outcomes and increased anxiety symptoms in adolescents. Regions like the hippocampus and amygdala, sensitive to stress, are particularly affected by early life adversities and play a role in anxiety disorders. This study suggests a potential neurobiological pathway connecting polyvictimization to the development of mental illness.
SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE
(2022)
Article
Clinical Neurology
Shu Yang, Li Yi, Xiaodi Xia, Xiaolu Chen, Xiao Hou, Longjie Zhang, Fang Yang, Jiaxin Liao, Zhijie Han, Yixiao Fu
Summary: This study used a rat model to investigate transcriptome changes in the amygdala-hippocampal neural network under chronic unpredictable mild stress (CUMS), and identified depression-related modules. Differential gene expression and enrichment analyses revealed candidate genes associated with neuronal myelination in the amygdala and synaptic transmission in the hippocampus. Furthermore, central genes were identified in both the amygdala and hippocampus modules through module hub gene statistics, differential gene expression, and protein-protein interaction networks.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Medicine, General & Internal
Bonnie Klimes-Dougan, Zeynep Basgoze, Bryon Mueller, Andrea Wiglesworth, Kathrine A. Carosella, Melinda Westlund Schreiner, Ana Bortnova, Kristina Reigstad, Kathryn R. Cullen, Meredith Gunlicks-Stoessel
Summary: This pilot study evaluated if baseline structure and function of specific brain regions can predict response to Interpersonal Psychotherapy for Depressed Adolescents. Results showed that greater activation and connectivity in certain brain regions were related to greater improvement in depression symptoms. However, brain structure had minimal predictive value.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Clinical Neurology
Hadas Nahman-Averbuch, Victor J. Schneider, Gregory R. Lee, James L. Peugh, Andrew D. Hershey, Scott W. Powers, Massimiliano de Zambotti, Robert C. Coghill, Christopher D. King
Summary: This case-control study examines the measures of subjective and objective sleep difficulties and their effects on amygdalar connectivity in adolescents with migraine. The study found that adolescents with migraine have greater connectivity between the amygdala and areas involved in sensory, affective, and cognitive aspects of pain. However, these differences in functional connectivity were not mediated by measures of sleep difficulties.
Article
Neurosciences
Melissa Gentreau, Christelle Reynes, Robert Sabatier, Jerome J. Maller, Chantal Meslin, Jeremy Deverdun, Emmanuelle Le Bars, Michel Raymond, Claire Berticat, Sylvaine Artero
Summary: The study found that high glycemic load diet and insulin resistance are associated with lower gray matter volumes in brain regions related to early dementia.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Laura K. M. Han, Richard Dinga, Tim Hahn, Christopher R. K. Ching, Lisa T. Eyler, Lyubomir Aftanas, Moji Aghajani, Andre Aleman, Bernhard T. Baune, Klaus Berger, Ivan Brak, Geraldo Busatto Filho, Angela Carballedo, Colm G. Connolly, Baptiste Couvy-Duchesne, Kathryn R. Cullen, Udo Dannlowski, Christopher G. Davey, Danai Dima, Fabio L. S. Duran, Verena Enneking, Elena Filimonova, Stefan Frenzel, Thomas Frodl, Cynthia H. Y. Fu, Beata R. Godlewska, Ian H. Gotlib, Hans J. Grabe, Nynke A. Groenewold, Dominik Grotegerd, Oliver Gruber, Geoffrey B. Hall, Ben J. Harrison, Sean N. Hatton, Marco Hermesdorf, Ian B. Hickie, Tiffany C. Ho, Norbert Hosten, Andreas Jansen, Claas Kaehler, Tilo Kircher, Bonnie Klimes-Dougan, Bernd Kraemer, Axel Krug, Jim Lagopoulos, Ramona Leenings, Frank P. MacMaster, Glenda MacQueen, Andrew McIntosh, Quinn McLellan, Katie L. McMahon, Sarah E. Medland, Bryon A. Mueller, Benson Mwangi, Evgeny Osipov, Maria J. Portella, Elena Pozzi, Liesbeth Reneman, Jonathan Repple, Pedro G. P. Rosa, Matthew D. Sacchet, Philipp G. Saemann, Knut Schnell, Anouk Schrantee, Egle Simulionyte, Jair C. Soares, Jens Sommer, Dan J. Stein, Olaf Steinstraeter, Lachlan T. Strike, Sophia I. Thomopoulos, Marie-Jose van Tol, Ilya M. Veer, Robert R. J. M. Vermeiren, Henrik Walter, Nic J. A. van der Wee, Steven J. A. van der Werff, Heather Whalley, Nils R. Winter, Katharina Wittfeld, Margaret J. Wright, Mon-Ju Wu, Henry Voelzke, Tony T. Yang, Vasileios Zannias, Greig I. de Zubicaray, Giovana B. Zunta-Soares, Christoph Abe, Martin Alda, Ole A. Andreassen, Erlend Boen, Caterina M. Bonnin, Erick J. Canales-Rodriguez, Dara Cannon, Xavier Caseras, Tiffany M. Chaim-Avancini, Torbjorn Elvsashagen, Pauline Favre, Sonya F. Foley, Janice M. Fullerton, Jose M. Goikolea, Bartholomeus C. M. Haarman, Tomas Hajek, Chantal Henry, Josselin Houenou, Fleur M. Howells, Martin Ingvar, Rayus Kuplicki, Beny Lafer, Mikael Landen, Rodrigo Machado-Vieira, Ulrik F. Malt, Colm McDonald, Philip B. Mitchell, Leila Nabulsi, Maria Concepcion Garcia Otaduy, Bronwyn J. Overs, Mircea Polosan, Edith Pomarol-Clotet, Joaquim Radua, Maria M. Rive, Gloria Roberts, Henricus G. Ruhe, Raymond Salvador, Salvador Sarro, Theodore D. Satterthwaite, Jonathan Savitz, Aart H. Schene, Peter R. Schofield, Mauricio H. Serpa, Kang Sim, Marcio Gerhardt Soeiro-de-Souza, Ashley N. Sutherland, Henk S. Temmingh, Garrett M. Timmons, Anne Uhlmann, Eduard Vieta, Daniel H. Wolf, Marcus V. Zanetti, Neda Jahanshad, Paul M. Thompson, Dick J. Veltman, Brenda W. J. H. Penninx, Andre F. Marquand, James H. Cole, Lianne Schmaal
Summary: Major depressive disorder is associated with increased risk of brain atrophy, aging-related diseases, and mortality. This study found that MDD patients showed a higher brain-predicted age difference compared to controls, but this difference did not seem to be driven by specific clinical characteristics. Subtle patterns of age-related structural brain abnormalities in MDD were observed, highlighting the need for further longitudinal studies to assess the clinical value of these findings.
MOLECULAR PSYCHIATRY
(2021)
Article
Neurosciences
Xiang-Zhen Kong, Clyde Francks
Summary: The problem of poor reproducibility of scientific findings has been a topic of concern in recent years. A recent multisite collaborative study investigated the reproducibility of brain anatomical left-right asymmetries in regional measures of surface area and cortical thickness. The study found an average reproducibility rate of 63.2%, with larger effects and larger datasets having higher reproducibility.
HUMAN BRAIN MAPPING
(2022)
Editorial Material
Psychology, Developmental
Frank P. MacMaster, David R. Rosenberg
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2021)
Article
Clinical Neurology
Cynthia K. Kahl, Adam Kirton, Tamara Pringsheim, Paul E. Croarkin, Ephrem Zewdie, Rose Swansburg, James Wrightson, Lisa Marie Langevin, Frank P. Macmaster
Summary: This study found that robot-driven, neuronavigated bilateral rTMS of the SMA is feasible in children with Tourette syndrome and appears to reduce tic severity. The primary outcome was a significant decrease in YGTSS score from baseline after treatment (p<0.001; Cohen's d=2.9), indicating the effectiveness of the treatment.
DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
(2021)
Article
Clinical Neurology
Sneha Chenji, Emily Cox, Natalia Jaworska, Rose M. Swansburg, Frank P. MacMaster
Summary: The study explored the relationship between body mass index (BMI) and hippocampal volume in youth with major depressive disorder (MDD). Results showed a reduction in right hippocampal volume in MDD youth with normal BMI, and a negative association between left hippocampal volume and BMI in MDD youth with high BMI. The findings suggest that BMI may play a role in the variability of hippocampal volume in MDD, highlighting the importance of considering BMI effects in future analyses.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Environmental Sciences
Ashley K. Dores, Gordon H. Fick, Frank P. MacMaster, Jeanne V. A. Williams, Andrew G. M. Bulloch, Scott B. Patten
Summary: The study found no evidence of association between outdoor air pollution and psychological depression in Canada. However, the results may not be generalizable due to the generally low levels of outdoor air pollution in the country.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Review
Emergency Medicine
Jean Deschamps, James Gilbertson, Sebastian Straube, Kathryn Dong, Frank P. MacMaster, Christina Korownyk, Lori Montgomery, Ryan Mahaffey, James Downar, Hance Clarke, John Muscedere, Katherine Rittenbach, Robin Featherstone, Meghan Sebastianski, Ben Vandermeer, Deborah Lynam, Ryan Magnussen, Sean M. Bagshaw, Oleksa G. Rewa
Summary: This study found that for patients presenting to acute healthcare settings with complications related to long-term opioid therapy, the most robust intervention is providing supports for patients in pain.
BMC EMERGENCY MEDICINE
(2021)
Article
Geriatrics & Gerontology
Sascha Gill, Meng Wang, Pauline Mouches, Deepthi Rajashekar, Tolulope Sajobi, Frank P. MacMaster, Eric E. Smith, Nils D. Forkert, Zahinoor Ismail
Summary: The study investigated the association of impulse dyscontrol symptoms with regional micro- and macro-structural brain properties in older adults with normal cognition, mild cognitive impairment, and Alzheimer's disease. The results showed that impulse dyscontrol was associated with changes in specific brain regions, including altered diffusion parameters and gray matter atrophy, indicating that impulse dyscontrol may be an early manifestation of AD.
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2021)
Article
Public, Environmental & Occupational Health
Genevieve Belleville, Marie-Christine Ouellet, Jessica Lebel, Sunita Ghosh, Charles M. Morin, Stephane Bouchard, Stephane Guay, Nicolas Bergeron, Tavis Campbell, Frank P. MacMaster
Summary: One year after the 2016 wildfires in Fort McMurray, 38% of evacuees had probable diagnoses of post-traumatic stress, major depressive, insomnia, generalized anxiety, or substance use disorders, with insomnia being the most common at 28.5%. Pre-existing mental health conditions and financial stress were significant risk factors for these disorders, while post-disaster consequences like decreased work and social life were predictors.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Health Care Sciences & Services
Gloria Obuobi-Donkor, Ejemai Eboreime, Jennifer Bond, Natalie Phung, Scarlett Eyben, Jake Hayward, Yanbo Zhang, Frank MacMaster, Steven Clelland, Russell Greiner, Chelsea Jones, Bo Cao, Suzette Bremault-Phillips, Kristopher Wells, Xin-Min Li, Carla Hilario, Andrew J. Greenshaw, Vincent Israel Opoku Agyapong
Summary: This project aims to provide accessible and cost-effective management therapy for first responders in Alberta, Canada, through SMS text messaging. The goal is to prevent and improve PTSI symptoms and enhance overall quality of life. The impact of text-based intervention on psychological symptoms will be evaluated and compared with the correspondents' demographic backgrounds.
JMIR RESEARCH PROTOCOLS
(2022)
Article
Psychology, Developmental
Tasmia Hai, Rose Swansburg, Cynthia K. Kahl, Hannah Frank, Kayla Stone, Jean-Francois Lemay, Frank P. MacMaster
Summary: We found that the right Superior Frontal Gyrus was thinner in children with ADHD, and this thickness was associated with inattentive and hyperactive symptoms as well as executive function.
JOURNAL OF ATTENTION DISORDERS
(2022)
Article
Psychology, Multidisciplinary
Jade A. Stein, Lianne M. Tomfohr-Madsen, Signe Bray, Frank P. MacMaster, Daniel C. Kopala-Sibley
Summary: This study investigated the relationship between dispositional mindfulness, Big Five personality traits, and psychopathology in adolescents at high risk for mood and anxiety disorders. The findings showed that higher dispositional mindfulness was associated with fewer psychological problems, with self-acceptance and nonreactivity playing key roles in this association. This suggests that techniques focusing on observation, along with enhancing nonreactivity and self-acceptance, should be emphasized in mindfulness interventions for adolescents in the future.
CURRENT PSYCHOLOGY
(2022)
Article
Education & Educational Research
Tasmia Hai, Rose Swansburg, Frank P. MacMaster, Jean-Francois Lemay
Summary: The study found that children with ADHD faced significant challenges in adapting to online learning during the COVID-19 pandemic. While the majority of ADHD children received web-based learning, fewer families reported educational materials that met their learning expectations during online classes, and children found it difficult to adjust to online learning.
FRONTIERS IN EDUCATION
(2021)
Article
Health Policy & Services
Emilie Binet, Marie-Christine Ouellet, Jessica Lebel, Vera Bekes, Charles M. Morin, Nicolas Bergeron, Tavis Campbell, Sunita Ghosh, Stephane Bouchard, Stephane Guay, Frank P. MacMaster, Genevieve Belleville
Summary: This study found that gender influenced post-disaster mental health services utilization, with women more likely than men to receive information, medication, and psychological help. Self-reliance was the main reason for not seeking help, while motivational barriers such as pessimism and stigma were more common than structural barriers.
ADMINISTRATION AND POLICY IN MENTAL HEALTH AND MENTAL HEALTH SERVICES RESEARCH
(2021)
Article
Psychology, Educational
Heather L. Craig, Gabrielle Wilcox, Erica M. Makarenko, Frank P. MacMaster
Summary: Teachers have a high rate of endorsement of neuromyths, mainly related to learning styles and multiple intelligences, indicating a need for further training in neuroscience.
CANADIAN JOURNAL OF SCHOOL PSYCHOLOGY
(2021)
Review
Neurosciences
Maya Jammoul, Dareen Jammoul, Kevin K. Wang, Firas Kobeissy, Ralph G. Depalma
Summary: This article reviews the possible mechanisms by which traumatic brain injury (TBI) may stimulate the development of opioid use disorder (OUD) and discusses the interaction between these two processes. CNS damage due to TBI appears to drive adverse effects of subsequent OUD, with pain being a risk factor for opioid use after TBI.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Danusa Mar Arcego, Jan-Paul Buschdorf, Nicholas O'Toole, Zihan Wang, Barbara Barth, Irina Pokhvisneva, Nirmala Arul Rayan, Sachin Patel, Euclides Jose de Mendonca Filho, Patrick Lee, Jennifer Tan, Ming Xuan Koh, Chu Ming Sim, Carine Parent, Randriely Merscher Sobreira de Lima, Andrew Clappison, Kieran J. O'Donnell, Carla Dalmaz, Janine Arloth, Nadine Provencal, Elisabeth B. Binder, Josie Diorio, Patricia Pelufo Silveira, Michael J. Meaney
Summary: This study investigates the impact of environmental influences on mental health by integrating transcriptomic data from animal models with human data. The results suggest that hippocampal glucocorticoid-related transcriptional activity mediates the effects of early adversity on neural mechanisms implicated in psychiatric disorders.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Milenna T. van Dijk, Ardesheer Talati, Pratik Kashyap, Karan Desai, Nora C. Kelsall, Marc J. Gameroff, Natalie Aw, Eyal Abraham, Breda Cullen, Jiook Cha, Christoph Anacker, Myrna M. Weissman, Jonathan Posner
Summary: This study found that maternal stress is associated with future depressive symptoms and alterations in microstructure of the dentate gyrus (DG) in offspring. These results were consistent across two independent cohorts.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Josephine C. McGowan, Liliana R. Ladner, Claire X. Shubeck, Juliana Tapia, Christina T. LaGamma, Amanda Anqueira-Gonzalez, Ariana DeFrancesco, Briana K. Chen, Holly C. Hunsberger, Ezra J. Sydnor, Ryan W. Logan, Tzong-Shiue Yu, Steven G. Kernie, Christine A. Denny
Summary: Traumatic brain injury (TBI) leads to fear generalization by altering fear memory traces, and this symptom can be improved with (R,S)-ketamine.
BIOLOGICAL PSYCHIATRY
(2024)