期刊
BIOLOGICAL CHEMISTRY
卷 395, 期 11, 页码 1275-1290出版社
WALTER DE GRUYTER GMBH
DOI: 10.1515/hsz-2014-0201
关键词
androgen receptor; chromatin remodeling; epigenetics; polycomb repressive complex (PRC); pseudogene; PTEN
资金
- German Federal Ministry of Education and Science [FKZ: 01KU1001A]
Prostate cancer (PCa) is the second most common cause of cancer-related deaths in men. Despite advances in the characterization of genomic and epigenetic aberrations contributing to PCa, the etiology of PCa is still far from being understood. Research over the past decade demonstrated the role of long non-coding RNAs (lncRNAs) in deregulation of target genes mainly through epigenetic mechanisms. In PCa, evidence accumulated that hundreds of lncRNAs are dysregulated. Functional analyses revealed their contribution to prostate carcinogenesis by targeting relevant pathways and gene regulation mechanisms including PTEN/AKT and androgen receptor signaling as well as chromatin remodeling complexes. Here we summarize our current knowledge on the roles of lncRNAs in PCa and their potential use as biomarkers for aggressive PCa and as novel therapeutic targets.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据