期刊
BIOLOGICAL CHEMISTRY
卷 395, 期 2, 页码 231-237出版社
WALTER DE GRUYTER GMBH
DOI: 10.1515/hsz-2013-0199
关键词
gene panel sequencing; target enrichment
Targeted re-sequencing such as gene panel sequencing (GPS) has become very popular in medical genetics, both for research projects and in diagnostic settings. The technical principles of the different enrichment methods have been reviewed several times before; however, new enrichment products are constantly entering the market, and researchers are often puzzled about the requirement to take decisions about long-term commitments, both for the enrichment product and the sequencing technology. This review summarizes important considerations for the experimental design and provides helpful recommendations in choosing the best sequencing strategy for various research projects and diagnostic applications.
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