Review
Environmental Sciences
Mitchell R. Slobodian, Jesse D. Petahtegoose, Athena L. Wallis, Danica C. Levesque, Thomas J. S. Merritt
Summary: The biological effects of environmental metal contamination, including essential and non-essential metals, are important issues that require more research to fully understand. Drosophila melanogaster is a promising insect model species for studying the impacts of metal toxicity, particularly in addressing the knowledge gaps between essential and non-essential metals. More studies using multiple metals, genetic backgrounds, and both sexes are needed to guide future research towards a better understanding of metal contamination effects.
Article
Biochemistry & Molecular Biology
Kumari Pragati Nanda, Hena Firdaus
Summary: This study utilized fruit flies to assess the effects of cadmium on animal behavior, revealing reduced locomotion and reproductive fitness after cadmium exposure. Transgenerational effects on locomotion were behavior-specific, and decreased antioxidant enzyme activity and altered essential element balance may be responsible for these effects.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2022)
Article
Agriculture, Multidisciplinary
Ya-Ru Xu, Milton Talukder, Chen-Xi Li, Cong Zhang, Jing Ge, Jin-Long Li
Summary: Nanoselenium (Nano-Se) plays a positive role in mitigating cadmium-induced brain injury by reducing cadmium accumulation, regulating gene and protein expressions, enhancing antioxidant capacity, and preserving normal tissue structure.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Environmental Sciences
Yiteng Xia, Karl W. K. Tsim, Wen-Xiong Wang
Summary: The subcellular trafficking of zinc ion in rabbitfish fin cells was found to be dose- and time-dependent. Zinc exhibited cytotoxicity when its concentration reached a certain threshold and homeostasis was disrupted when the concentration exceeded a certain level and exposure time exceeded 3 hours. Lysosomes played a major role in regulating zinc homeostasis, while mitochondria were found to be the primary organelles affected by zinc toxicity.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Multidisciplinary Sciences
Brian J. Earley, Ciro Cubillas, Kurt Warnhoff, Raheel Ahmad, Alan Alcantar, Maximilian D. Lyon, Daniel L. Schneider, Kerry Kornfeld
Summary: This study demonstrates that cadmium can regulate transcription by mimicking the physiological role of zinc, affecting the high zinc response. By analyzing related genes, specific resistance pathways for high zinc and cadmium, as well as a shared pathway, have been identified.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Microbiology
Xiaohui Li, Liu Chen, Yuankun Wang, Xiao Guo, Zheng-Guo He
Summary: As a necessary element, zinc plays a crucial role in proteins. However, excess zinc can be toxic. This study explores the antibacterial signaling pathway triggered by zinc excess in Mycobacterium bovis and its relationship with iron homeostasis. The findings reveal the existence of the Zur-IdeR-iron homeostasis pathway and shed light on the crosstalk mechanisms between zinc and iron in bacteria, as well as the antimicrobial mechanisms of host-mediated zinc toxicity.
MICROBIOLOGY SPECTRUM
(2023)
Article
Biotechnology & Applied Microbiology
I. V. N. Rathnayake, Mallavarapu Megharaj, Michael Beer, Ravi Naidu
Summary: The study found that the components of microalgal media have a significant impact on the bioavailability of metals in the medium, leading to variations in bioassay results depending on the growth medium used. The free metal content in each medium varied with the concentrations of metals added. Tolerance of microalgae to metals differed significantly depending on the growth medium used and also varied between species of the same genus.
JOURNAL OF APPLIED PHYCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Bo Zhang, Qintao Zhang, Xinting Zhu, Dayu Li, Xiaolei Duan, Jiao Jin, Kejia Wang, Yan Xie, Yang Liu
Summary: Zinc and cadmium strongly inhibit the activity of DNA-repair protein CaPif1, a helicase responsible for genomic stability. Zinc inhibits ATPase and unwinding activities, while cadmium inhibits through binding to cysteine residues. Low concentrations of ATP can weaken zinc's inhibitory effect, while cysteine can reduce cadmium's inhibitory effect. The inhibitory effects of both metals are greater in reduced environments. This study provides insights into the mechanisms of heavy metal toxicity on DNA-repair proteins.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Plant Sciences
Ameneh Vafaie Moghadam, Alireza Iranbakhsh, Sara Saadatmand, Mostafa Ebadi, Zahra Oraghi Ardebili
Summary: This study investigated the physiological, epigenetic, and transcriptional responses of Datura stramonium to long-term exposure to different concentrations of zinc oxide nanoparticles. It found that lower concentrations promoted growth and nutrient absorption, while higher concentrations caused phytotoxicity and changes in gene expression related to metal accumulation. These findings deepen our understanding of the molecular mechanisms involved in plant responses to nanomaterial exposure.
JOURNAL OF PLANT GROWTH REGULATION
(2022)
Article
Biochemistry & Molecular Biology
Matilde Forcella, Pierre Lau, Marco Fabbri, Paola Fusi, Monica Oldani, Pasquale Melchioretto, Laura Gribaldo, Chiara Urani
Summary: Harmful modifications in different tissues-organs can occur after exposure to cadmium, leading to relevant diseases. The molecular mimicry of cadmium and its ability to cause metal ions dyshomeostasis represent the initial common feature leading to different molecular signatures and alterations, possibly responsible for different pathological conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Mingyang Liu, Yuqing Zhang, Jingxuan Yang, Hanxiang Zhan, Zhijun Zhou, Yuanyuan Jiang, Xiuhui Shi, Xiao Fan, Junxia Zhang, Wenyi Luo, Kar-Ming A. Fung, Chao Xu, Michael S. Bronze, Courtney W. Houchen, Min Li
Summary: The study revealed that ZIP4 activates ZEB1 and YAP1 to regulate pancreatic cancer metastasis and EMT plasticity, with significant impact on tumor progression and spread.
Article
Plant Sciences
Marie Luyckx, Jean-Francois Hausman, Kjell Sergeant, Gea Guerriero, Stanley Lutts
Summary: This study found that zinc and cadmium have different impacts on plant metabolism, and silicon can enhance the stress tolerance of plants to heavy metals.
FRONTIERS IN PLANT SCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Yakun Li, Lihong Ding, Mei Zhou, Zhixiang Chen, Yanfei Ding, Cheng Zhu
Summary: Cadmium, a highly toxic non-essential heavy metal, can be sensed, transported, and detoxified by plants through specialized mechanisms. Recent studies have identified numerous transporters involved in Cd uptake, transport, and detoxification. However, the intricate transcriptional regulatory networks associated with Cd response are still not fully understood.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Plant Sciences
Jagna Chmielowska-Bak, Joanna Deckert
Summary: The global concern over environmental metal pollution and its impact on plant performance and human food chain transmission is significant. Limited reports exist on plant recovery after metal stress, with studies largely conducted in laboratory settings examining the recovery of various plant species to different metals and concentrations. Recovery mechanisms include stress memory acquisition, adaptation to unfavorable conditions, and cross-tolerance towards other stress factors.
Article
Agronomy
Roger H. Tang, Peter D. Erskine, Philip Nti Nkrumah, Guillaume Echevarria, Antony van der Ent
Summary: Metallophytes are plants that can tolerate extreme metal concentrations in soil. A study on the Dugald River gossan in Australia found that there was no direct relationship between the occurrence of metallophytes and prevailing soil metal concentrations. Crotalaria novae-hollandiae was identified as a strong polymetallic indicator-type metallophyte that can accumulate high concentrations of metals in its leaves.
Article
Biochemistry & Molecular Biology
Katharina Schoenrath, Wensheng Pan, Andres J. Klein-Szanto, Karl-Heinz Braunewell
MOLECULAR CARCINOGENESIS
(2011)
Article
Multidisciplinary Sciences
Katharina Schoenrath, Andres J. Klein-Szanto, Karl H. Braunewell
Article
Psychiatry
K. H. Braunewell, A. D. Dwary, F. Richter, K. Trappe, C. Zhao, I. Giegling, K. Schoenrath, D. Rujescu
TRANSLATIONAL PSYCHIATRY
(2011)
Article
Geriatrics & Gerontology
Björn Kuhla, Katharina Boeck, Hans-Joachim L th, Angela Schmidt, Bernd Weigle, Marc Schrnitz, Vera Ogunlade, Gerald M nch, Thomas Arendt
NEUROBIOLOGY OF AGING
(2006)
