期刊
BIOLOGICAL CHEMISTRY
卷 395, 期 10, 页码 1179-1185出版社
WALTER DE GRUYTER GMBH
DOI: 10.1515/hsz-2014-0156
关键词
deubiquitination; initiation of protein synthesis; NF-kappa B inactivation; papain-like cysteine proteinase; substrate specificity
资金
- Austrian Science Foundation [P20889, P24038]
- Austrian Science Fund (FWF) [P20889, P24038] Funding Source: Austrian Science Fund (FWF)
- Austrian Science Fund (FWF) [P 24038] Funding Source: researchfish
The leader proteinase (L-pro) of the foot-and-mouth disease virus inhibits the host innate immune response by at least three different mechanisms. The most well-characterised of these is the prevention of the synthesis of cytokines such as interferons immediately after infection, brought about by specific proteolytic cleavage of the eukaryotic initiation factor 4G. This prevents the recruitment of capped cellular mRNA; however, the viral RNA can be translated under these conditions. The two other mechanisms are the induction of NF-kappa B cleavage and the deubiquitination of immune signalling molecules. This review focuses on the structure-function relationships in Lpro responsible for these widely divergent activities.
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