Structure, mechanism and inhibition of γ-secretase and presenilin-like proteases

Effect of Tarenflurbil on Cognitive Decline and Activities of Daily Living in Patients With Mild Alzheimer DiseaseA Randomized Controlled Trial

(2009) Robert C. Green   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Intramembrane-cleaving Proteases

(2009) Michael S. Wolfe   JOURNAL OF BIOLOGICAL CHEMISTRY

Intramembrane Proteolysis by Signal Peptide Peptidases: A Comparative Discussion of GXGD-type Aspartyl Proteases

(2009) Regina Fluhrer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Substrate specificity of γ-secretase and other intramembrane proteases

(2008) A. J. Beel et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

γ-Secretase: Structure, Function, and Modulation for Alzheimers Disease

(2008) Michael Wolfe   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Transmembrane Domain 9 of Presenilin Determines the Dynamic Conformation of the Catalytic Site of γ-Secretase

(2008) Alexandra Tolia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Role of Amyloid Precursor Protein Processing by BACE1, the β-Secretase, in Alzheimer Disease Pathophysiology

(2008) Sarah L. Cole et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cryoelectron Microscopy Structure of Purified γ-Secretase at 12 Å Resolution

(2008) Pamela Osenkowski et al.   JOURNAL OF MOLECULAR BIOLOGY

The C-Terminal PAL Motif and Transmembrane Domain 9 of Presenilin 1 Are Involved in the Formation of the Catalytic Pore of the  -Secretase

(2008) C. Sato et al.   JOURNAL OF NEUROSCIENCE

Substrate-targeting γ-secretase modulators

(2008) Thomas L. Kukar et al.   NATURE