Lipoprotein receptors – an evolutionarily ancient multifunctional receptor family

LRP4 Mutations Alter Wnt/β-Catenin Signaling and Cause Limb and Kidney Malformations in Cenani-Lenz Syndrome

(2010) Yun Li et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Low Density Lipoprotein Receptor-related Protein 1 (LRP1) Forms a Signaling Complex with Platelet-derived Growth Factor Receptor-β in Endosomes and Regulates Activation of the MAPK Pathway

(2010) Selen Catania Muratoglu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ectodomains of the LDL Receptor-Related Proteins LRP1b and LRP4 Have Anchorage Independent Functions In Vivo

(2010) Martin F. Dietrich et al.   PLoS One

Lrp4 Regulates Initiation of Ureteric Budding and Is Crucial for Kidney Formation – A Mouse Model for Cenani-Lenz Syndrome

(2010) Courtney M. Karner et al.   PLoS One

ApoE4 reduces glutamate receptor function and synaptic plasticity by selectively impairing ApoE receptor recycling

(2010) Y. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reduction of SorLA/LR11, a Sorting Protein Limiting β-Amyloid Production, in Alzheimer Disease Cerebrospinal Fluid

(2009) Qiu-Lan Ma et al.   ARCHIVES OF NEUROLOGY

BRCA1-associated breast and ovarian cancer risks in Poland: no association with commonly studied polymorphisms

(2009) Anna Jakubowska et al.   BREAST CANCER RESEARCH AND TREATMENT

Low-Density Lipoprotein Receptor-Related Protein 1 Promotes Cancer Cell Migration and Invasion by Inducing the Expression of Matrix Metalloproteinases 2 and 9

(2009) H. Song et al.   CANCER RESEARCH

Clearance of Amyloid-β Peptide Across the Blood-Brain Barrier: Implication for Therapies in Alzheimers Disease

(2009) R. Deane et al.   CNS & Neurological Disorders-Drug Targets

Reelin Stabilizes the Actin Cytoskeleton of Neuronal Processes by Inducing n-Cofilin Phosphorylation at Serine3

(2009) X. Chai et al.   JOURNAL OF NEUROSCIENCE

LRP1 shedding in human brain: roles of ADAM10 and ADAM17

(2009) Qiang Liu et al.   Molecular Neurodegeneration

LRP1 Regulates Architecture of the Vascular Wall by Controlling PDGFRβ-Dependent Phosphatidylinositol 3-Kinase Activation

(2009) Li Zhou et al.   PLoS One

Reelin signaling antagonizes  -amyloid at the synapse

(2009) M. S. Durakoglugil et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Insulin stimulates hepatic low density lipoprotein receptor-related protein 1 (LRP1) to increase postprandial lipoprotein clearance

(2008) Alexander Laatsch et al.   ATHEROSCLEROSIS

Lrp4 Is a Receptor for Agrin and Forms a Complex with MuSK

(2008) Natalie Kim et al.   CELL

Part-Time α-Secretases: The Functional Biology of ADAM 9, 10 and 17

(2008) Miriam Deuss et al.   Current Alzheimer Research

The Role of the Cell Surface LRP and Soluble LRP in Blood-Brain Barrier Aβ Clearance in Alzheimers Disease

(2008) R. Deane et al.   CURRENT PHARMACEUTICAL DESIGN

Thrombospondin-1 binds to ApoER2 and VLDL receptor and functions in postnatal neuronal migration

(2008) Sophia M Blake et al.   EMBO JOURNAL

Cerebellar hypoplasia, with quadrupedal locomotion, caused by mutations in the very low-density lipoprotein receptor gene

(2008) S Türkmen et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Ectodomain cleavage of the EGF ligands HB-EGF, neuregulin1-β, and TGF-α is specifically triggered by different stimuli and involves different PKC isoenzymes

(2008) Andreas Herrlich et al.   FASEB JOURNAL

The Functional Role of the Second NPXY Motif of the LRP1 β-Chain in Tissue-type Plasminogen Activator-mediated Activation ofN-Methyl-D-aspartate Receptors

(2008) Anne M. Martin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Megalin Mediates Selenoprotein P Uptake by Kidney Proximal Tubule Epithelial Cells

(2008) Gary E. Olson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hhat Is a Palmitoylacyltransferase with Specificity forN-Palmitoylation of Sonic Hedgehog

(2008) John A. Buglino et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reduction of Crk and CrkL expression blocks reelin-induced dendritogenesis

(2008) T. Matsuki et al.   JOURNAL OF CELL SCIENCE

apoE isoform–specific disruption of amyloid β peptide clearance from mouse brain

(2008) Rashid Deane et al.   JOURNAL OF CLINICAL INVESTIGATION

The Reelin Signaling Pathway Promotes Dendritic Spine Development in Hippocampal Neurons

(2008) S. Niu et al.   JOURNAL OF NEUROSCIENCE

Somatic mutations affect key pathways in lung adenocarcinoma

(2008) Li Ding et al.   NATURE

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

(2008) Ganesh M Shankar et al.   NATURE MEDICINE

Multiple roles for lipids in the Hedgehog signalling pathway

(2008) Suzanne Eaton   NATURE REVIEWS MOLECULAR CELL BIOLOGY

LRP4 Serves as a Coreceptor of Agrin

(2008) Bin Zhang et al.   NEURON

LDL Receptor-Related Protein 1: Unique Tissue-Specific Functions Revealed by Selective Gene Knockout Studies

(2008) Anna P. Lillis et al.   PHYSIOLOGICAL REVIEWS

Lrp4 Modulates Extracellular Integration of Cell Signaling Pathways in Development

(2008) Atsushi Ohazama et al.   PLoS One

Mutations in the very low-density lipoprotein receptor VLDLR cause cerebellar hypoplasia and quadrupedal locomotion in humans

(2008) T. Ozcelik et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure and function of γ-secretase

(2008) Alexandra Tolia et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Lipoprotein receptors and cholesterol in APP trafficking and proteolytic processing, implications for Alzheimer's disease

(2008) Maria-Paz Marzolo et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The FE65 proteins and Alzheimer's disease

(2007) Declan M. McLoughlin et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Thrombospondins Use the VLDL Receptor and a Nonapoptotic Pathway to Inhibit Cell Division in Microvascular Endothelial Cells

(2007) Anush Oganesian et al.   MOLECULAR BIOLOGY OF THE CELL