期刊
BIOLOGICAL CHEMISTRY
卷 390, 期 8, 页码 717-722出版社
WALTER DE GRUYTER GMBH
DOI: 10.1515/BC.2009.101
关键词
import; localization; mitochondria; protein complex; tRNA
资金
- NIGMS NIH HHS [R01 GM084065, R01 GM022854] Funding Source: Medline
Mitochondrial translation is important for the synthesis of proteins involved in oxidative phosphorylation, which yields the bulk of the ATP made in cells. During evolution most mitochondria-containing organisms have lost tRNA genes from their mitochondrial genomes. Thus, to support the essential process of nuanced mitochondrial translation, mechanisms to actively transport tRNAs from the cytoplasm across the mitochondrial membranes into the mitochondrion have evolved. Here, we review the currently known tRNA import mechanisms, comment on recent discoveries of various import factors, and suggest a rationale for forces that lie behind the evolution of mitochondrial tRNA import.
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