Article
Oncology
Lyndsey S. Crump, Garhett Wyatt, Taylor R. Rutherford, Jennifer K. Richer, Weston W. Porter, Traci R. Lyons
Summary: SEMA7A is found to decrease patient survival rates in ER+ breast cancer, induce resistance to hormonal therapy, and drive metastasis. Targeting the prosurvival signaling pathway of SEMA7A(+) tumors may be efficacious in treating such tumors.
Article
Medicine, Research & Experimental
Jinchao Song, Jiankui Du, Xing Tan, Yang Li, Qing Yu, Wen Liu, Xiaoyan Zhu, Binhai Cong
Summary: Tissue kallikrein-related peptidase8 (KLK8) has been found to aggravate cardiac remodeling in response to acute myocardial ischemia-reperfusion (IR) injury. KLK8 overexpression enhances cardiac dysfunction, fibrosis, and hypertrophy after IR injury, possibly mediated by the epidermal growth factor receptor (EGFR) signaling in cardiac fibroblasts (CFs). This study highlights the importance of KLK8 in cardiac remodeling after myocardial infarction.
Article
Biochemistry & Molecular Biology
Bethany M. Moore, Yun Sun Lee, Peipei Wang, Christina Azodi, Erich Grotewold, Shin-Han Shiu
Summary: The modeling and experimental validation of transcriptional response to wounding and jasmonic acid identified temporal cis-regulatory codes and new regulatory sequences important for wound response. The study provides a global predictive model for wound response and highlights the significance of regulatory factors and open chromatin regions in different types of wound response.
Review
Plant Sciences
Rui Miao, Eugenia Russinova, Pedro L. Rodriguez
Summary: The enzyme activity of the plasma membrane proton pump in plants is regulated by phosphorylation, specifically through phosphorylation of a threonine residue. Understanding this complex regulatory mechanism may lead to new strategies for sustainable agriculture.
TRENDS IN PLANT SCIENCE
(2022)
Article
Horticulture
Cengiz Kaya, Ferhat Ugurlar
Summary: Horticultural crops play a crucial role in global food, nourishment, and economies, but they face challenges from both biotic and abiotic stressors, resulting in decreased productivity and quality. Melatonin (MT) shows great potential in regulating gene expression and stress responses in horticultural crops, particularly through its interactions with key phytohormones. Through its effects on gene expression and chromatin structure, MT enhances stress tolerance in plants and improves their ability to combat stressors.
SCIENTIA HORTICULTURAE
(2023)
Review
Medicine, Research & Experimental
Nayara Azinheira Nobrega Cruz, Danielle Stoll, Dulce Elena Casarini, Mariane Bertagnolli
Summary: This review explores the impact of SARS-CoV-2 infection on pregnancy, focusing on the role of ACE2 in viral entry and potential risks related to ACE2 changes in COVID-19 pregnancies. The study highlights the importance of understanding ACE2's functions in physiological systems during pregnancy and the necessity of filling knowledge gaps to improve management of high-risk pregnancies with COVID-19 exposure.
Article
Fisheries
Shiqi Ao, Wenjing Xu, Qianqian Ding, Xiaojian Gao, Xiaojun Zhang, Qun Jiang
Summary: The aim of this study was to assess the glucose tolerance of the giant freshwater prawn, Macrobrachium rosenbergii, and investigate the underlying mechanisms that regulate glucose homeostasis. Results showed that M. rosenbergii demonstrated a rapid clearance of exogenous glucose and can efficiently regulate glucose homeostasis by activating glycolysis and anabolism pathways to convert glucose into trehalose, glycogen, and triglyceride.
Article
Multidisciplinary Sciences
Lauren B. Sands, Samuel R. Haiden, Yi Ma, Gerald A. Berkowitz
Summary: Cannabissativa aromatic prenyltransferase 4 (CsPT4) and 1 (CsPT1) play a crucial role in catalyzing the biosynthesis of cannabigerolic acid (CBGA) in cannabis plants. These genes are highly expressed in flowers, and their promoters exhibit activity in leaves and glandular trichomes. This study investigates the hormonal regulation of CsPT4 and CsPT1 promoters and their impact on cannabinoid synthesis. The findings suggest an interaction between hormones and cannabinoid synthesis, providing insights into plant biology and gene expression regulation.
SCIENTIFIC REPORTS
(2023)
Review
Cell Biology
Elly I. Lewerissa, Nael Nadif Kasri, Katrin Linda
Summary: Autophagy is a crucial metabolic process for maintaining cellular homeostasis and survival. Recent studies have shown the importance of autophagy in brain function, particularly in neuronal development and functioning. Mutations in autophagy-related genes as well as genes involved in epigenetic regulation have been linked to neurodevelopmental disorders (NDDs). This suggests that aberrant autophagic regulation may contribute to nervous system impairments in NDDs with disturbed epigenetic regulation.
Article
Biochemistry & Molecular Biology
Hye Rin Jeong, Jong Min Kim, Uk Lee, Jin Yong Kang, Seon Kyeong Park, Hyo Lim Lee, Jong Hyun Moon, Min Ji Kim, Min Ji Go, Ho Jin Heo
Summary: This study evaluated the protective effects of ethyl acetate fraction from Cedrela sinensis (EFCS) against behavioral dysfunction and stress response induced by chronic unpredictable mild stress (CUMS) in mice. The results showed that EFCS alleviated depression-like behavior, inhibited mitochondrial dysfunction, regulated stress hormones, and downregulated inflammatory responses and apoptosis proteins in brain tissues.
Article
Multidisciplinary Sciences
Jin-Xiu Li, Xue-Zhen Huang, Wei-ping Fu, Xiao-hua Zhang, David H. Mauki, Jing Zhang, Chang Sun, Lu-Ming Dai, Li Zhong, Li Yu, Ya-ping Zhang
Summary: This study conducted comprehensive bioinformatics analyses and experimental verifications to explore the regulatory mechanism of rs10516526 and GSTCD in COPD. The results showed that low expression of GSTCD was associated with COPD, and the transcription factors C-Jun and CREB1 were found to be essential for the regulation of GSTCD by specific genetic signals. Moreover, certain mutated forms of these signals showed a stronger binding ability to the transcription factors, potentially leading to allele-specific regulation and reduced susceptibility to COPD.
Article
Biotechnology & Applied Microbiology
Shu-Lei Jia, Zhe Chi, Lu Chen, Guang-Lei Liu, Zhong Hu, Zhen-Ming Chi
Summary: Many genes responsible for melanin biosynthesis in fungi were physically linked together, and most of the melanin-producing fungi had PKS gene clusters regulated by Cmr1. Close rearrangement of PKS gene clusters had evolved in these fungi, with various beneficial functions of melanin helping them adapt to changing environments. The fungi had undergone at least five large-scale differentiations, leading to rapid evolution of their PKS gene clusters and adaptation to diverse environments. Recent gene losses and expansion in the PKS gene clusters were frequent, indicating rapid evolution and adaptation of the fungi to different environments. Strong co-evolution was observed between PKS gene and CMR1 gene, but horizontal gene transfer events may have occurred in the genome-duplicated species Aspergillus and Penicillium.
Review
Agriculture, Dairy & Animal Science
Long Guo, Junhu Yao, Yangchun Cao
Summary: The unique structure of the stomach in ruminant animals leads to differences in nutrient digestion compared to monogastric animals. Improving small intestine digestion, particularly starch digestion, is crucial for high-yield ruminants. Research on pancreatic exocrine regulation in ruminants is hindered by factors such as the complex structure of the pancreas and internal and external influences.
Article
Biochemistry & Molecular Biology
Oksana O. Kolachevskaya, Yulia A. Myakushina, Irina A. Getman, Sergey N. Lomin, Igor Deyneko, Svetlana Deigraf, Georgy A. Romanov
Summary: Auxins and cytokinins play crucial roles in regulating plant growth and development, with their interactions being complex and organ-specific. Gene expression is influenced by hormones and sucrose content, leading to functional clustering of genes from the same family. The study sheds new light on the crosstalk between auxin- and cytokinin signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Agronomy
Mengjiao Li, Hui Tian, Yajun Gao
Summary: Duplication events are common in the NPF and NRT2 gene families in the wheat genome, with NPF genes mainly located on chromosome groups 2, 3, and 7, and NRT2 genes primarily on chromosome group 6. Coexpression analysis revealed multiple transcription factor families associated with NPF and NRT2 genes. Two NPFs and one NRT2 demonstrated nitrate transport activity under different nitrate concentrations.
Article
Cell Biology
Fay Betsou, Alexandre Bulla, Sang Yun Cho, Judith Clements, Rodrigo Chuaqui, Domenico Coppola, Yvonne De Souza, Annemieke De Wilde, William Grizzle, Fiorella Guadagni, Elaine Gunter, Stacey Heil, Verity Hodgkinson, Joseph Kessler, Michael Kiehntopf, Hee Sung Kim, Iren Koppandi, Katheryn Shea, Rajeev Singh, Marc Sobel, Stella Somiari, Demetri Spyropoulos, Mars Stone, Gunnel Tybring, Klara Valyi-Nagy, Gert Van den Eynden, Lalita Wadhwa
BIOPRESERVATION AND BIOBANKING
(2016)
Review
Biochemical Research Methods
Lakmali Munasinghage Silva, Judith Ann Clements
EXPERT REVIEW OF PROTEOMICS
(2017)
Article
Dermatology
Simon J. de Veer, Laetitia Furio, Joakim E. Swedberg, Christopher A. Munro, Maria Brattsand, Judith A. Clements, Alain Hovnanian, Jonathan M. Harris
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2017)
Article
Cell & Tissue Engineering
V. M. C. Quent, A. V. Taubenberger, J. C. Reichert, L. C. Martine, J. A. Clements, D. W. Hutmacher, D. Loessner
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2018)
Article
Oncology
Thomas Kryza, Lakmali M. Silva, Nathalie Bock, Ruth A. Fuhrman-Luck, Carson R. Stephens, Jin Gao, Hema Samaratunga, Mitchell G. Lawrence, John D. Hooper, Ying Dong, Gail P. Risbridger, Judith A. Clements
MOLECULAR ONCOLOGY
(2017)
Article
Multidisciplinary Sciences
Lakmali Munasinghage Silva, Thomas Stoll, Thomas Kryza, Carson Ryan Stephens, Marcus Lachlan Hastie, Helen Frances Irving-Rodgers, Ying Dong, Jeffrey John Gorman, Judith Ann Clements
SCIENTIFIC REPORTS
(2017)
Article
Food Science & Technology
Ivan Koludarov, Timothy N. W. Jackson, Bianca op den Brouw, James Dobson, Daniel Dashevsky, Kevin Arbuckle, Christofer J. Clemente, Edward J. Stockdale, Chip Cochran, Jordan Debono, Carson Stephens, Nadya Panagides, Bin Li, Mary-Louise Roy Manchadi, Aude Violette, Rudy Fourmy, Iwan Hendrikx, Amanda Nouwens, Judith Clements, Paolo Martelli, Hang Fai Kwok, Bryan G. Fry
Article
Multidisciplinary Sciences
Nathalie Bock, Thomas Kryza, Ali Shokoohmand, Joan Rohl, Akhilandeshwari Ravichandran, Marie-Luise Wille, Colleen C. Nelson, Dietmar W. Hutmacher, Judith A. Clements
Summary: The all-human microtissue-engineered model of mineralized metastatic tissue plays a crucial role in understanding the bone tumor microenvironment and treatment response in mCRPC, with enzalutamide demonstrating better therapeutic efficacy compared to bicalutamide in a mineralized microenvironment.
Review
Biochemistry & Molecular Biology
Hannu Koistinen, Ruusu-Maaria Kovanen, Morley D. Hollenberg, Antoine Dufour, Evette S. Radisky, Ulf-Hakan Stenman, Jyotsna Batra, Judith Clements, John D. Hooper, Eleftherios Diamandis, Oliver Schilling, Antti Rannikko, Tuomas Mirtti
Summary: Since the proposition of the pro-invasive activity of proteolytic enzymes over 70 years ago, several roles for proteases in cancer progression have been established. About half of the 473 active human proteases are expressed in the prostate and many of the most well-characterized members of this enzyme family are regulated by androgens, hormones essential for development of prostate cancer. Most notably, several kallikrein-related peptidases, including KLK3 (prostate-specific antigen, PSA), the most well-known prostate cancer marker, and type II transmembrane serine proteases, such as TMPRSS2 and matriptase, have been extensively studied and found to promote prostate cancer progression. Recent findings also suggest a critical role for proteases in the development of advanced and aggressive castration-resistant prostate cancer (CRPC). Perhaps the most intriguing evidence for this role comes from studies showing that the protease-activated transmembrane proteins, Notch and CDCP1, are associated with the development of CRPC.
Article
Engineering, Biomedical
Agathe Bessot, Jennifer Gunter, David Waugh, Judith A. Clements, Dietmar W. Hutmacher, Jacqui McGovern, Nathalie Bock
Summary: Increasing evidence highlights the important role of bone marrow adipocytes in prostate cancer bone metastases. However, lack of relevant models has hindered the understanding of human BM-adipocyte effects in this microenvironment. This study combines tunable GelMA-based hydrogels with biomimetic culture of human cells to engineer human bone tumor microenvironments containing BM-adipocytes. In vitro culture of human osteoprogenitors, adipocytes, and PCa cells in GelMA hydrogels leads to the formation of mineralized, adipose, and PCa tumor 3D microtissues, respectively. The stiffness of hydrogels regulates osteoblast mineralization and tumor spheroid formation, while coculture with tumor cells induces morphological changes and delipidation in BM-adipocytes. The in vivo model successfully forms a humanized fatty bone microenvironment and demonstrates that adipocytes support early bone tumor growth. This advanced platform combines natural aspects of the microenvironment with tunable properties for bone tumor research.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Oncology
Leire Moya, Carina Walpole, Fiona Rae, Srilakshmi Srinivasan, Inge Seim, John Lai, David Nicol, Elizabeth D. Williams, Judith A. Clements, Jyotsna Batra
Summary: This study successfully established four cell lines derived from localized prostate cancer, including two benign and two malignant cell lines. The characteristics and molecular events of these cell lines could help in understanding the development and progression of cancer.
PROSTATE CANCER AND PROSTATIC DISEASES
(2023)
Review
Oncology
Fatemeh Davoudi, Afshin Moradi, Therese M. M. Becker, John G. G. Lock, Brian Abbey, Davide Fontanarosa, Annette Haworth, Judith Clements, Rupert C. C. Ecker, Jyotsna Batra
Summary: Prostate cancer is a commonly diagnosed malignant neoplasm and a leading cause of cancer-related death in men worldwide. Personalized therapeutic strategies for this disease remain limited, but emerging biomarkers based on individual patient profiles and computer-assisted diagnostics have the potential to guide precision medicine. This review discusses screening methods, genetic aberrations, and phenotypic biomarkers for advanced prostate cancer, exploring their clinical implications in diagnosis, prognosis, and treatment prediction. Prognostic and treatment predictive biomarker discovery can improve patient management and personalized treatment regimens.
CURRENT TREATMENT OPTIONS IN ONCOLOGY
(2023)
Review
Oncology
Srilakshmi Srinivasan, Thomas Kryza, Jyotsna Batra, Judith Clements
Summary: This review discusses the complex biology of kallikrein-related peptidases and their role in cancer and the tumor microenvironment. It also explores their involvement in tumor immune suppression and resistance to cancer therapy. Understanding the functions of these peptidases can provide insights into tumor development and help in developing new therapeutic strategies.
NATURE REVIEWS CANCER
(2022)
Article
Oncology
Nina Pauline Holzapfel, Ali Shokoohmand, Ferdinand Wagner, Marietta Landgraf, Simon Champ, Boris Michael Holzapfel, Judith Ann Clements, Dietmar Werner Hutmacher, Daniela Loessner
AMERICAN JOURNAL OF CANCER RESEARCH
(2017)
Article
Oncology
Artitaya Lophatananon, Sarah Stewart-Brown, Zsofia Kote-Jarai, Ali Amin Al Olama, Sara Benlloch Garcia, David E. Neal, Freddie C. Hamdy, Jenny L. Donovan, Graham G. Giles, Liesel M. Fitzgerald, Melissa C. Southey, Paul Pharoah, Nora Pashayan, Henrik Gronberg, Fredrik Wiklund, Markus Aly, Janet L. Stanford, Hermann Brenner, Aida K. Dieffenbach, Volker Arndt, Jong Y. Park, Hui-Yi Lin, Thomas Sellers, Chavdar Slavov, Radka Kaneva, Vanio Mitev, Jyotsna Batra, Amanda Spurdle, Judith A. Clements, Douglas Easton, Rosalind A. Eeles, Kenneth Muir
BRITISH JOURNAL OF CANCER
(2017)