New biological activity against phospholipase A2 by Turmerin, a protein from Curcuma longa L

Turmerin is a protein from Turmeric (Curcuma longa L.) with a relative molecular mass of 14 kDa. The protein inhibits the enzymatic activity and neutralises the pharmacological properties, such as cytotoxicity, oedema and myotoxicity of multitoxic phospholipase, A(2) (NV-PLA(2)) of cobra (Naja naja) venom at a 1:2.5 molar ratio of NV-PLA(2):Turmerin. A Lineweaver-Burk plot indicates that Turmerin follows a linear mixed type of inhibition.