Article
Plant Sciences
Luis Apaza Ticona, Karla Slowing, Andreea Madalina Serban, Marcos Humanes Bastante, Maria J. Hernaiz
Summary: This study evaluated the wound healing, anti-inflammatory, and anti-melanogenic activities of the aqueous extract of Semialarium mexicanum. Three compounds were isolated and characterized, which showed significant activities in inhibiting inflammation, melanin production, and promoting wound healing.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Camille Keisha Mahendra, Hooi-Leng Ser, Syafiq Asnawi Zainal Abidin, Shafi Ullah Khan, Priyia Pusparajah, Thet Thet Htar, Lay-Hong Chuah, Siah Ying Tang, Long Chiau Ming, Khang Wen Goh, Yatinesh Kumari, Bey Hing Goh
Summary: This research focuses on the anti-pigmentation properties of Swietenia macrophylla seeds. Ethanol extraction and fractionation based on polarity were performed, followed by testing on zebrafish embryos. The ethanolic extract showed significant inhibition of tyrosinase activity and melanin production. Proteomic studies confirmed the downregulation of cathepsin LB and cytoskeletal proteins related to melanogenic pathway. Limonoids in the seed demonstrated stronger binding affinity to TYRP-1 than kojic acid, suggesting their potential in inhibiting pigmentation. Further studies and assays are needed for development of these phytocompounds into a skin whitening agent.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Chemistry, Medicinal
Luis Apaza Ticona, Blanca Perez-Uz, Maria Teresa Garcia Esteban, Francisco Aguilar Rico, Karla Slowing
Summary: Hibiscus sabdariffa L., a plant in the Malvaceae family, is known for its industrial, medicinal, and cosmetic uses. Its aqueous extract, rich in polyphenolic compounds, has been extensively studied for its biological properties. The extract showed inhibitory effects on tyrosinase activity, melanin production, and NO production, indicating its potential as an anti-melanogenic and anti-inflammatory agent.
REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY
(2022)
Article
Biotechnology & Applied Microbiology
Yen-Wenn Liu, Chi-Mei Liu, Hung-Yueh Chen, Darin Khumsupan, Hsien-Yi Hsu, Hui-Wen Lin, Chang-Wei Hsieh, Kuan-Chen Cheng
Summary: Ganoderma formosanum, an endemic medicinal mushroom in Taiwan, exhibited significant reduction of melanin activity through ethyl acetate extraction of its mycelium, which inhibits tyrosinase. Optimization of G. formosanum mycelium production with anti-melanogenic activity was conducted by investigating different variables (carbon sources and concentrations, initial pH value, and temperature). The optimal conditions involved the use of 50 g/L lactose as the carbon source at pH 7 and 25 degrees C for 9 days. Subsequently, the G. formosanum ethanolic extracts-optimized (GFE-O) were found to effectively reduce intracellular melanin content in B16-F10 melanoma cells and induce hypopigmentation in zebrafish embryo in a non-toxic manner.
FERMENTATION-BASEL
(2023)
Article
Dermatology
Sirima Boonjing, Varisa Pongrakhananon, Wantanee Sittiwong, Kuntarat Arunrungvichian, Rawiwan Maniratanachote, Paninee Chetprayoon
Summary: Through a series of experiments, we identified two compounds with anti-pigmentation activity and an interaction with tyrosinase. These findings provide an alternative approach for the development of skin-whitening products that do not require animal testing.
EXPERIMENTAL DERMATOLOGY
(2022)
Review
Chemistry, Medicinal
Md Khursheed, Hardik Ghelani, Reem K. Jan, Thomas E. Adrian
Summary: Inflammation is a defense mechanism of the body, but chronic inflammation is involved in the pathogenesis of various diseases. Marine organisms produce bioactive compounds with anti-inflammatory activities, which have potential for developing new drugs.
Review
Nutrition & Dietetics
Amel Taibi, Zoe Lofft, Bianca Laytouni-Imbriaco, Elena Maria Comelli
Summary: Cranberries contain anti-inflammatory properties due to their polyphenol profile, particularly the A-type proanthocyanidin (PAC). The gut microbiota can metabolize PACs into organic acids, which contribute to the health benefits of cranberries. This review explores the potential role of microRNAs in mediating the anti-inflammatory effects of cranberry polyphenols and their metabolites. The use of microRNAs as biomarkers in this context is also discussed.
FRONTIERS IN NUTRITION
(2023)
Review
Biochemistry & Molecular Biology
Shih-Chun Yang, Ahmed Alalaiwe, Zih-Chan Lin, Yu-Chih Lin, Ibrahim A. Aljuffali, Jia-You Fang
Summary: miRNA plays a critical role in regulating skin inflammation and has anti-inflammatory features. miRNA-based therapies could be potential candidates for treating skin inflammation.
Article
Chemistry, Applied
Li Zhao, Xiaoling Zhu, Yue Yu, Langzhi He, Yubing Li, Li Zhang, Rui Liu
Summary: The study revealed that peanut skin extract has an inhibitory effect on glycation, mainly achieved through binding interaction with BSA, attenuating the formation of early glycation products, and trapping reactive dicarbonyl compounds.
Article
Pharmacology & Pharmacy
Kanokwan Singpanna, Koranat Dechsri, Prasopchai Patrojanasophon, Panupun Limpachayaporn, Praneet Opanasopit, Nopparat Nuntharatanapong
Summary: CBE-loaded liposomes were developed to improve skin penetration and anti-melanogenic activity of CBE, with low cytotoxicity to human normal skin cells and mouse melanoma cells.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Chemistry, Medicinal
Se-eun Lee, Min-ju Kim, Prima F. Hillman, Dong-Chan Oh, William Fenical, Sang-Jip Nam, Kyung-Min Lim
Summary: This study found that the marine microbial natural product deoxyvascinone has an anti-melanogenic effect by inhibiting the mRNA expression of melanogenic enzymes, reducing melanin content.
Article
Chemistry, Medicinal
Luis Apaza Ticona, Andreea Madalina Serban, Maria J. Puerto Madorran, Maria Fernandez-Grifol, Angel Rumbero Sanchez
Summary: The three pentacyclic triterpenes isolated from Jatropha macrantha Mull.Arg., namely oleanolic acid, azarolic acid, and 3-oxo euscaphic acid, showed anti-inflammatory and anti-melanogenic activities. Among them, azarolic acid exhibited the highest inhibitory activity on NF-kappa B production and tyrosinase, as well as similar Nrf2 activation potential to the positive control.
REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY
(2021)
Article
Biochemistry & Molecular Biology
Se-Hui Jung, Hee-Young Heo, Jung-Won Choe, Jaehyun Kim, Kooyeon Lee
Summary: The study revealed the importance of the structure of velutin in its anti-melanogenesis activity, with hydroxyl and methoxy groups at both C5 and C7 positions being essential for inhibiting tyrosinase activity, while 1,2-diol compounds substituted at C3' and C4' induced apoptosis of melanoma cells, and substitution with methoxy or hydrogen at C3' and C4' was crucial for inhibiting melanogenesis. This research could aid in the development of natural-derived materials for regulating melanin synthesis.
Article
Plant Sciences
M. Madiba, B. B. Oluremi, Z. Gulube, O. O. Oderinlo, M. Marimani, P. M. Osamudiamen, M. Patel
Summary: Uvaria chamae root extract exhibits antibacterial and anti-caries activities, and can inhibit the adherence and acidogenic activity of Streptococcus mutans.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Microbiology
Sol Lee, Han-Oh Park, Wonbeak Yoo
Summary: This study investigates the effects of cell-free supernatant from Lactobacillus gasseri BNR17 on anti-melanogenesis and reducing oxidative stress in both murine melanoma cells and human keratinocytes. The results show that the cell-free supernatant can effectively inhibit melanin production and has antioxidative effects.