期刊
BIOLOGICAL & PHARMACEUTICAL BULLETIN
卷 33, 期 6, 页码 1063-1066出版社
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/bpb.33.1063
关键词
idesolide; C2C12; muscle atrophy; heat shock protein
资金
- Ministry of Education, Science and Technology [2008-03190]
- National Research Foundation of Korea [2008-03190] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Muscle disorders, such as muscular dystrophy, are associated with an increase in oxidative stress. Proposed treatments for muscular dystrophy, sonic in clinical trials, include gene therapy and muscle cell transplantation. In this study, we investigated the effects of idesolide, isolated from the fruits of Idesia polycarpa, on changes that occur in muscle disuse atrophy. We noted protective effects on oxidative stress response and HSP70 regulation. Pre-treatment with idesolide for 24 h maintained cell viability and decreased apoptosis in H2O2-treated C2C12 muscle cells. The idesolide pretreatment also increased intracellular HSP70 protein. Our results suggest that idesolide inhibits cell death through induction of HSP70 in C2C12 muscle cells. This work is the first to report that idesolide can regulate the decrease in HSP70 that occurs during skeletal muscle atrophy.
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