Article
Multidisciplinary Sciences
Weiqing Zhang, Robert D. Willows, Rui Deng, Zheng Li, Mengqi Li, Yan Wang, Yunling Guo, Weida Shi, Qiuling Fan, Shelley S. Martin, Nathan C. Rockwell, J. Clark Lagarias, Deqiang Duanmu
Summary: The biosynthesis of chlorophyll and heme in oxygenic phototrophs follows a common pathway that diverges with the insertion of magnesium or iron. The interaction of bilins with GENOMES UNCOUPLED 4 (GUN4) stimulates the enzymatic activity of magnesium chelatase (MgCh) and stabilizes the accumulation of protoporphyrin IX-binding CrCHLH1 subunit of MgCh. GUN4: bilin complexes play dual regulatory roles in sustaining bilin biosynthesis and chlorophyll biosynthesis in illuminated oxic environments of all photosynthetic eukaryotes.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Hiromu Ito, Hiromi Kurokawa, Hirofumi Matsui
Summary: Mitochondria, essential organelles for energy production in eukaryotes, generate reactive oxygen species during the process which play pivotal roles in cell signaling and iron homeostasis regulation. The regulation of iron transportation, involving proteins like HCP1, DMT1, and mitoferrin, is increasingly understood in relation to mitochondrial reactive oxygen species and diseases.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Cell Biology
Ok-Joo Sul, Hyo-Jung Hyun, Monisha Rajasekaran, Jae-Hee Suh, Hye-Seon Choi
Summary: The loss of ovarian function leads to increased body weight and fat mass due to decreased adipose tissue browning caused by estrogen deficiency. Exogenous estrogen can reverse this change, while M2 polarization mediated by heme oxygenase-1 can enhance adipose tissue browning.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Food Science & Technology
Yen-Chuan Ou, Jian-Ri Li, Chih-Cheng Wu, Tung-Min Yu, Wen-Ying Chen, Su-Lan Liao, Yu-Hsiang Kuan, Yu-Fan Chen, Chun-Jung Chen
Summary: Cadmium induces kidney toxicity through oxidative stress and inflammation. This study investigates the reciprocal crosstalk among oxidative stress, inflammation, and the nuclear Nrf2 pathway in cadmium-induced nephrotoxicity. The results suggest a role for HO-1 as a linking molecule in mediating nephrotoxicity-associated IL-6 expression upon cadmium exposure.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Review
Plant Sciences
John T. Hancock, Tyler W. LeBaron, Jennifer May, Adam Thomas, Grace Russell
Summary: Although the use of molecular hydrogen (H-2) for enhanced plant growth and postharvest storage of crops has not been widely accepted in the UK, evidence shows that it can alleviate plant stress and slow crop senescence. The effects of H-2 treatment appear to be mediated by the alteration of plant cell antioxidant capacity, with potential benefits in agriculture if the costs are justified. Hydrogen-rich water (HRW) is considered safe and relatively easy to use, suggesting that it could potentially be widely adopted in the UK and help reduce food waste in the future.
Article
Oncology
Peiran Cong, Guangming Huang, Yuanyuan Zhao, Yuhuai Lan
Summary: This study investigated the potential inhibitory effect of Hydroxysafflor yellow A (HSYA) on myocardial fibrosis induced by isoproterenol (ISO) and angiotensin II (Ang II). The results showed that HSYA significantly inhibited myocardial fibrosis, NLRP3 inflammasome activation, and inflammatory cytokine expressions. In vitro, HSYA reduced the proliferation and migration of cardiac fibroblasts (CFs) and suppressed the accumulation of collagen. The study suggests that HSYA may inhibit myocardial fibrosis by blocking the NLRP3 pathway in CFs.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2022)
Article
Immunology
Bitna Kweon, Dong-Uk Kim, Jin-Young Oh, Gi-Sang Bae, Sung-Joo Park
Summary: Guggulsterone (GS) exerts anti-inflammatory effects by inducing heme oxygenase-1 (HO-1) expression through reactive oxygen species (ROS) production. GS inhibits the expression of inflammatory mediators and prolongs survival in an endotoxemia model.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Cell Biology
Shih-Kai Chiang, Shuen-Ei Chen, Ling-Chu Chang
Summary: HO-1 plays a significant role in oxidative stress and tumorigenesis, regulating key signaling pathways in the progression of cancer. While the relationship between HO-1 and cancer development has not been thoroughly examined, it holds great potential in advancing research in this area.
Article
Biochemistry & Molecular Biology
Eduardo P. Amaral, Caian L. Vinhaes, Deivide Oliveira-de-Souza, Betania Nogueira, Kevan M. Akrami, Bruno B. Andrade
Summary: Persistent and exacerbated oxidative stress responses in chronic tuberculosis are associated with severe pathology. Inhibition of this stress response by improving host antioxidant status may be a strategy to reduce tissue damage. Future research should focus on host-directed therapy to prevent severe immunopathology in TB.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Article
Oncology
Ko Abe, Sho Ikeda, Miho Nara, Akihiro Kitadate, Hiroyuki Tagawa, Naoto Takahashi
Summary: This study found that multiple myeloma cells in hypoxic microenvironments have specific highly expressed protein-coding genes, including HMOX1, BACH2, and DUX4. The study also found that HMOX1 plays an important role in hypoxia-induced resistance to proteasome inhibitors and is strongly positively correlated with MAFB. The research suggests that the hypoxia-ROS-HMOX1 axis and hypoxia-induced MAFB may be important mechanisms of proteasome inhibitor resistance in hypoxic microenvironments.
Article
Pharmacology & Pharmacy
Cornelius Hermann, Simon Lang, Tanja Popp, Susanne Hafner, Dirk Steinritz, Alexis Rump, Matthias Port, Stefan Eder
Summary: The study demonstrated that the synthetic triterpenoid CDDO-Me can reduce the growth of OSCC tumors and exhibit anti-cancer and radio-sensitizing effects in malignant cells. However, it did not lead to significant detrimental consequences in non-malignant keratinocytes. These findings suggest the potential of utilizing CDDO-Me treatment to broaden the therapeutic range of clinical radiotherapy.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Lishan Huang, Zhou Chen, Ruiyu Chen, Lu Lin, Lingjia Ren, Meilian Zhang, Libin Liu
Summary: The mechanism of severe hypoglycemia-induced cardiovascular disease in diabetes is unclear. This study reveals that increased fatty acid metabolism reduces the resistance of cardiomyocytes to 8-adrenoceptor activation during hypoglycemia, leading to cardiac dysfunction and mitochondrial damage. Mitochondrial ROS plays a pivotal role in this process. Reducing mitochondrial ROS could disrupt this synergistic effect and prevent poor cardiac outcomes caused by severe hypoglycemia.
Article
Pharmacology & Pharmacy
Lihe Lu, Yining Li, Qian Dong, Jiansong Fang, An Chen, Zirong Lan, Yuanzhi Ye, Jianyun Yan, Qingchun Liang
Summary: This study combined systems pharmacology-based strategy and experiments to identify the therapeutic potential of Wogonin for vascular calcification via upregulating heme oxygenase-1 (HMOX-1) and reducing oxidative stress.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Suong T. Nguyen, Daniel Du, Daniel Wychrij, Matthew D. Cain, Qingping Wu, Robyn S. Klein, Ilaria Russo, Daniel E. Goldberg
Summary: Histidine-rich protein II (HRPII) secreted by Plasmodium falciparum during the blood stage of malaria infection contributes to cerebral malaria by inducing vascular leakage. HRPII, characterized by large multimeric particles laden with hemes, can bind and internalize into cerebral microvascular endothelial cells through caveolin-mediated endocytosis. The release of hemes and subsequent activation of inflammasome pathway result in endothelial leakage. Inhibiting these pathways can protect the integrity of the blood-brain barrier (BBB) and reduce the morbidity and mortality of cerebral malaria.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Biochemistry & Molecular Biology
Atefeh Afsar, Maria del Carmen Chacon Castro, Adedamola Saidi Soladogun, Li Zhang
Summary: Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by neurofibrillary tangles, amyloid beta plaque deposition, and neurodegeneration. Genetic mutations, inflammation, blood-brain barrier impairment, mitochondrial dysfunction, oxidative stress, and metal ion imbalance are associated with AD progression. Recent studies have shown a link between altered heme metabolism and AD. Understanding the underlying mechanisms and identifying therapeutic targets is crucial for AD drug development. This review discusses common alterations in AD, potential therapeutic targets, mathematical models, and treatment strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)