Article
Immunology
Jae-Young Park, Hyo-Min Park, Seonhwa Kim, Kyeong-Bae Jeon, Chae-Min Lim, Jin Tae Hong, Do-Young Yoon
Summary: IL-32 theta A94V, a mutant isoform, can inhibit monocyte-endothelial adhesion by binding to integrins aVb3 and aVb6, thus reducing the early step of atherosclerosis.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Elisabeth J. M. Huijbers, Kabir A. Khan, Robert S. Kerbel, Arjan W. Griffioen
Summary: Tumors can escape immunity by inducing a state of unresponsiveness in tumor vasculature, leading to compromised immune responses. By mimicking embryonic mechanisms through angiogenesis, tumors enforce immune privileged conditions to ensure uninterrupted growth.
SCIENCE IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Dicky L. Tahapary, Tasykuru Rizqa, Cut Vania Syarira, Lusiani Lusiani, Aulia Rizka, Syahidatul Wafa, Wismandari Wisnu, Tri Juli Edi Tarigan, Dante Saksono Harbuwono
Summary: This study aimed to determine the changes in ICAM-1 levels in patients with type 2 diabetes mellitus (T2DM) and non-DM patients during Ramadan fasting. The results showed that both T2DM and non-DM patients had a significant decrease in ICAM-1 levels after Ramadan fasting, but only non-DM patients had a significantly lower post-Ramadan ICAM-1 level.
Article
Cell Biology
Shin Takasawa, Mai Makino, Akiyo Yamauchi, Sumiyo Sakuramoto-Tsuchida, Rina Hirota, Ryusei Fujii, Keito Asai, Yoshinori Takeda, Tomoko Uchiyama, Ryogo Shobatake, Hiroyo Ota
Summary: Sleep apnea syndrome (SAS) exposes cells to intermittent hypoxia (IH), resulting in increased expression of ICAM-1 and ESM1. This upregulation is mediated by the IH-induced downregulation of microRNA-181a1, and may lead to the development of atherosclerosis in SAS patients.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)
Article
Cell Biology
Eun-Ji Lim, Jae-Hyeok Kang, Yeon-Ju Kim, Seungmo Kim, Su-Jae Lee
Summary: ICAM-1 is a potential therapeutic target for colorectal cancer (CRC) that enhances treatment effectiveness by promoting the c-MET-SRC signaling axis. Treatment with antibodies targeting ICAM-1 can reduce metastasis and angiogenesis in CRC.
CELL DEATH & DISEASE
(2022)
Article
Oncology
Wenjuan Ma, Yanling Wang, Rongxin Zhang, Fan Yang, Duo Zhang, Menggui Huang, Lin Zhang, Jay F. Dorsey, Zev A. Binder, Donald M. O'Rourke, Joseph A. Fraietta, Yanqing Gong, Yi Fan
Summary: The study identifies PAK4 as a selective regulator of genetic reprogramming and aberrant vascularization in GBM-derived ECs, highlighting its potential as a target for cancer immunotherapy. Inhibition of PAK4 normalizes the tumor vascular microenvironment and enhances the sensitivity of glioblastomas to CAR-T cell immunotherapy.
Article
Cell Biology
Ram Kuwar, Xuejun Wen, Ning Zhang, Dong Sun
Summary: This study investigated the role of integrins in promoting adhesion, growth, development, and vascular-like network formation of rat primary brain microvascular endothelial cells. By using an integrin-binding array platform, specific types of integrins and their binding peptides were identified. Furthermore, a 3D hydrogel culture system functionalized with these binding peptides promoted robust growth and lumenized microvascular-like network formation of brain microvascular endothelial cells.
NEURAL REGENERATION RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Jun-Hei Chang, Chen-Chuan Cheng, Yen-Yu Lu, Cheng-Chih Chung, Yung-Hsin Yeh, Yao-Chang Chen, Satoshi Higa, Shih-Ann Chen, Yi-Jen Chen
Summary: VEGF reduces PV arrhythmogenesis by modulating sodium/calcium homeostasis through VEGFR-1/NOS signaling pathway.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Oncology
Keiichiro Mori, Victor M. Schuettfort, Satoshi Katayama, Ekaterina Laukhtina, Benjamin Pradere, Fahad Quhal, Reza Sari Motlagh, Hadi Mostafaei, Nico C. Grossmann, Pawel Rajwa, Jeremy Yc Teoh, Irene Resch, Harun Fajkovic, Marco Moschini, David D'andrea, Mohammad Abufaraj, Pierre Karakiewicz, Yair Lotan, Douglas Scherr, Shin Egawa, Eva Comperat, Shahrokh F. Shariat
Summary: Elevated plasma VCAM-1 levels are associated with aggressive UCB disease features and can be used as a biomarker to identify patients who may benefit from intensified/multimodal therapy. Adding VCAM-1 to predictive models significantly improves their discriminatory ability. VCAM-1 can also be used to refine personalized clinical decision-making.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Review
Biology
Cameron D. Haydinger, Liam M. Ashander, Alwin Chun Rong Tan, Justine R. Smith
Summary: Intercellular adhesion molecule 1 (ICAM-1) is a transmembrane protein that plays important roles in the immune system and is involved in various diseases. It mediates cellular adhesive interactions and is upregulated in inflammation. This review provides a comprehensive summary of the structure and regulation of ICAM1 gene and the ICAM-1 protein, discusses its functions in the immune system and diseases, and explores current therapeutics and future advancements.
Article
Immunology
Qianqian Guo, Kunimaro Furuta, Shahidul Islam, Nunzia Caporarello, Enis Kostallari, Kobe Dielis, Daniel J. J. Tschumperlin, Petra Hirsova, Samar H. H. Ibrahim
Summary: The study reveals that VCAM1 not only functions as a scaffold for leukocyte adhesion during liver injury, but also modulates LSEC capillarization and liver fibrosis.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Medicine, Research & Experimental
Alayi Bolatai, Yujing He, Na Wu
Summary: This paper summarizes the mechanisms of unbalanced VEGF and receptor expression based on data from relevant literature on GDM and eclampsia. An imbalance in VEGF and its binding receptor is often associated with the occurrence of multiple pregnancy disorders. In recent years, researchers have focused on the potential role of VEGF and its receptors in the development of GDM and eclampsia.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Neurosciences
Jonathan D. Drake, Alison B. Chambers, Brian R. Ott, Lori A. Daiello
Summary: The study found that plasma-based vascular biomarkers, particularly VCAM-1 and ICAM-1, were associated with Alzheimer's disease (AD) and clinical impairment. VCAM-1 was linked with clinical dementia rating sum-of-boxes (CDR-SB) scores, with the APOE epsilon 4 genotype modifying this relationship. Additionally, combining VCAM-1 and cerebrospinal fluid (CSF) biomarkers showed independent associations with AD-related clinical impairment.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Microbiology
M. Wang, J. -W. Xie, Y. -W. Zheng, X. -T. Wang, D. -Y. Yi, Y. Lin, M. -I. Tong, L. -R. Lin
Summary: Tp47-microvesicles promote the adhesion of THP-1 cells to HUVECs by upregulating ICAM-1 and VCAM-1 expression through the activation of the ERK1/2 and NF-κB pathways. These findings provide insights into the pathophysiology of syphilitic vascular inflammation.
MICROBIOLOGY SPECTRUM
(2023)
Article
Medicine, Research & Experimental
Masaki Arioka, Fumi Seto-Tetsuo, Takeru Inoue, Koichi Miura, Shin Ishikane, Kazunobu Igawa, Katsuhiko Tomooka, Fumi Takahashi-Yanaga, Toshiyuki Sasaguri
Summary: This study reveals that DIF-1 reduces the adhesion of tumor cells to blood vessels by inhibiting mTORC1-S6K signaling and decreasing the expression of adhesion molecule VCAM-1 on vascular endothelial cells. These findings highlight the potential of DIF-1 as a promising compound for the development of anti-cancer drugs with anti-metastatic properties.