Review
Allergy
Andrew W. Liu, Jacob E. Gillis, Tina L. Sumpter, Daniel H. Kaplan
Summary: The skin is populated by various immune cells and sensory neurons, and the interaction between the nervous and immune systems plays a crucial role in inflammatory skin diseases. Neurotransmitters secreted by nerve terminals mediate immune cell function, while immune factors derived from immune cells interact with neurons to induce itching. This review explores the effector functions of neurons on skin immune cells in mouse models of atopic and contact dermatitis, and discusses the contribution of specific neuronal subsets and immune factors to itch induction and inflammation. The findings also shed light on treatment strategies and the relationship between scratching and dermatitis.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Review
Allergy
Andreas Wollenberg, Simon Francis Thomsen, Jean-Philippe Lacour, Xavier Jaumont, Slawomir Lazarewicz
Summary: Immunoglobulin E (IgE) is important in allergic diseases, and omalizumab is the primary biologic anti-IgE therapy available in clinical use. Limited studies show inconclusive efficacy of omalizumab in atopic dermatitis (AD), but it may be effective in certain patients. Further robust clinical studies are needed to establish the role of omalizumab in AD.
WORLD ALLERGY ORGANIZATION JOURNAL
(2021)
Review
Pharmacology & Pharmacy
Pier Giorgio Puzzovio, Francesca Levi-Schaffer
Summary: The understanding of the pathologic mechanisms of asthma and atopic dermatitis has improved in recent years. However, the high heterogeneity of both diseases complicates diagnosis and treatment, with current strategies mainly focusing on symptom control rather than full healing. There is a need for more personalized approaches to improve diagnosis and treatment efficacy.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Julius Garcia Gatmaitan, Ji Hyun Lee
Summary: Atopic dermatitis is a complex condition with various factors affecting its treatment and management. In addition to conventional therapies, new drugs targeting specific molecular pathways in atopic dermatitis are being developed to address its complex pathophysiology. The efficacy of these drugs depends on factors such as genotype, environmental triggers, microbiome-derived signals, and immune responses. This review highlights the challenges and recent pharmacological developments in atopic dermatitis, aiming for a more personalized therapeutic approach.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Immunology
Mohammad-Hossein Shams, Reza Jafari, Nahid Eskandari, Mohsen Masjedi, Farnaz Kheirandish, Mazdak Ganjalikhani Hakemi, Ramin Ghasemi, Ali-Mohammad Varzi, Seyyed-Mohsen Sohrabi, Peyman Amanolahi Baharvand, Mozhgan Safari
Summary: Allergic diseases have significantly increased globally in recent decades, influenced by genetic factors, industrialization, improved hygiene, and climate change. Changes in lifestyle and diet habits also play a key role in the prevalence of allergic diseases.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Veterinary Sciences
Marike Visser, Kelly Walsh, Vickie King, Gordon Sture, Laura Caneva
Summary: The study evaluated the oral acceptance of oclacitinib maleate (Apoquel (R)) chewable tablets in 121 client-owned dogs in the United States. The results showed that the chewable tablets were well tolerated and highly palatable, making them a good alternative to the film-coated tablet for the treatment of allergic or atopic dermatitis.
BMC VETERINARY RESEARCH
(2022)
Article
Dermatology
Zhen Zhang, Jiawen Chen, Yijun Yang, Ruoqu Wei, Peiyi Sun, Wenqing Zhang, Wange Zhou, Yifeng Guo, Zhirong Yao
Summary: Intravenous immunoglobulin (IVIG) therapy has shown efficacy and safety in children with severe atopic dermatitis (AD). Treatment response was seen in 60% of patients, with significant improvement in Scoring Atopic Dermatitis index. Furthermore, baseline total serum IgE levels and eosinophil counts decreased significantly after treatment.
DERMATOLOGIC THERAPY
(2022)
Review
Immunology
Anni Xie, Ailing Chen, Yuqing Chen, Zichen Luo, Shanyu Jiang, Daozhen Chen, Renqiang Yu
Summary: Atopic dermatitis is a chronic inflammatory skin disease with itching and swelling. Probiotics, especially certain strains of Lactobacillus, can provide a safe and effective way to treat and prevent AD by regulating the immune system and improving gut health.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Health Care Sciences & Services
Shung-Jie Chang, Ho-Chang Kuo, Wen-Jiun Chou, Ching-Shu Tsai, Sheng-Yu Lee, Liang-Jen Wang
Summary: This study examines the relationship between cytokine levels, neuropsychological function, and behavioral manifestations in patients with attention deficit hyperactivity disorder (ADHD) and atopic diseases. The study finds that behavioral symptoms and attention scores are significantly different between individuals with and without ADHD, regardless of atopic diseases. However, plasma levels of certain cytokines are negatively correlated with inattention symptoms.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Dermatology
Hadley Johnson, Marcella R. Aquino, Alan Snyder, Reid W. Collis, Katlein Franca, Alina Goldenberg, Jennifer Y. Sui, Dawn Z. Eichenfield, Brittany J. Kozy, Jennifer K. Chen, Chelsea Shope, Ari M. Goldminz, JiaDe Yu
Summary: Children with atopic dermatitis are more likely to have allergic contact dermatitis and should undergo evaluation and patch testing for allergic contact dermatitis.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2023)
Article
Allergy
Magdalena Krupka-Olek, Andrzej Bozek, Milena Drewienkowska, Krzysztof Dryjka, Agata Medrala
Summary: This study analyzed a group of adult patients with concomitant psoriasis and atopic dermatitis, and compared their cytokine profiles with those of homogeneous psoriasis or atopic dermatitis patients and healthy controls. The results suggest that the role of T helper 17 cells may be more essential than previously thought.
ALLERGOLOGIA ET IMMUNOPATHOLOGIA
(2022)
Article
Biotechnology & Applied Microbiology
Buket Kunduhoglu, Seda Hacioglu
Summary: This study explored the gluten hydrolysis ability and probiotic potential of Lact. brevis KT16-2, which showed promising results in terms of surviving in adverse conditions, producing antimicrobial peptides, and exhibiting high antioxidant activity.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2021)
Article
Pediatrics
Ling-Sai Chang, Hsin-Yu Chang, Yao-Hsu Yang, Zon-Min Lee, Mindy Ming-Huey Guo, Ying-Hsien Huang, Ho-Chang Kuo
Summary: Fruits are nutritious and contain immune-regulating ingredients, providing protective effects against asthma. However, allergic reactions to fruits can manifest as oral allergy syndrome. This study investigated the patterns and factors associated with fruit allergen-specific IgE sensitization among patients with suspected clinical symptoms.
Article
Dermatology
Kwei-Lan Liu, Tsung-Lin Tsai, Wen-Chien Tsai, Shih-Fen Tsai, Chih-Hung Lee, Shu-Li Wang
Summary: Prenatal exposure to heavy metals may increase the risk of atopic diseases in children. In atopic children, serum tIgE levels peaked at the age of 11, while they remained stable from the age of 8 in non-atopic children.
JOURNAL OF DERMATOLOGY
(2021)
Article
Environmental Sciences
Juan Wang, Christer Janson, Andrei Malinovschi, Mathias Holm, Karl A. Franklin, Lars Modig, Ane Johannessen, Vivi Schluenssen, Thorarinn Gislason, Nils Oskar Jogi, Dan Norback
Summary: This study examined the relationship between home environment exposures and asthma, allergic rhinitis, and atopic dermatitis among offspring of participants in the Respiratory Health in Northern Europe (RHINE) study. The results showed that dampness/mold at home and living in new buildings were associated with asthma occurrence.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)