Article
Chemistry, Analytical
Kaline Rodrigues Carvalho, Guilherme Juliao Zocolo, Edy Sousa de Brito, Edilberto Rocha Silveira, Kirley Marques Canuto
Summary: A new method using solid-phase microextraction coupled with gas chromatography and mass spectrometry has been developed to discriminate between two chemotypes of the medicinal herb Egletes viscosa. The optimized extraction conditions showed that this method is more efficient and able to extract a greater number of compounds compared to conventional hydrodistillation. This non-destructive method demonstrates potential for chemical screening and quality control in pharmaceutical and cosmetic industries.
MICROCHEMICAL JOURNAL
(2021)
Article
Chemistry, Medicinal
Yaodong Ning, Shi Zhang, Te Zheng, Yao Xu, Song Li, Jianpeng Zhang, Binghua Jiao, Yun Zhang, Zengling Ma, Xiaoling Lu
Summary: The Arctic-derived fungus Eutypella sp. D-1 can produce secondary metabolites with excellent biological activity, some of which exhibit significant anti-inflammatory effects. Seven pimarane-type diterpenes, including three new compounds, were isolated from the fermentation broth of Eutypella sp. D-1. These compounds showed inhibitory effects on cell NO release in vitro and demonstrated anti-inflammatory activity in a zebrafish model.
Article
Chemistry, Medicinal
Chao Wang, Quan-Hao Wei, Zhen-Qiang Xin, Lin -Lin Tian, Jun-Sheng Zhang, Hua Zhang
Summary: This study reported new compounds from the root extract of Morinda officinalis and determined their structures and absolute configurations using spectroscopic analysis and computational methods. These compounds showed moderate inhibitory activity against nitric oxide production in murine macrophage cells, and compound 3b also inhibited the secretion of two inflammatory cytokines.
Article
Chemistry, Medicinal
Yu-Fei Liu, Bao-Chen Yang, Zhi-Min Song, Lin-Qiang Qiao, Rui Peng, Wei-Sheng Feng, Yong-Xian Cheng, Yan-Zhi Wang
Summary: The phytochemical investigation of the ethanol extract from Pinus yunnanensis Franch resin led to the discovery of six new diterpenoids and the determination of their structures using spectroscopic analysis and computational methods. These compounds showed anti-inflammatory effects at certain concentrations.
Article
Chemistry, Applied
Thi Men Ngo, Phuong Thao Tran, Le Son Hoang, Jeong-Hyung Lee, Byung Sun Min, Jeong Ah Kim
Summary: Four new diterpene-type compounds and twelve known compounds were isolated from the roots of Salvia miltiorrhiza, and their ability to inhibit nitric oxide production was evaluated. Compound 11 showed a strong inhibitory effect with an IC50 value of 3.4 +/- 1.2 μM.
NATURAL PRODUCT RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Kuan-Ming Chiu, Yen-Ling Hung, Su-Jane Wang, Yi-Ju Tsai, Nan-Lin Wu, Cher-Wei Liang, Der-Chen Chang, Chi-Feng Hung
Summary: Neferine has anti-allergic and anti-inflammatory effects on mast cells by inhibiting degranulation and cytokine expression, decreasing intracellular calcium levels, and reducing the phosphorylation of the MAPK/NF-kappa B pathway. In vivo studies demonstrate that neferine improves dermatitis appearance, mast cell infiltration, and restores barrier protein expression. Neferine also reduces scratching behavior induced by compound 48/80, suggesting its potential as a natural product for skin allergy and inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Natsuki Kubota-Ishida, Takashi Matsuhira, Chizuko Kaji, Chika Kikuchi, Yuji Tabata
Summary: The study compared the effects of a novel PDE4 inhibitor, AA6216, with crisaborole on skin inflammation, showing that AA6216 is a more potent inhibitor of PDE4 and of cytokine production. In mouse models of dermatitis, AA6216 significantly suppressed skin inflammation, suggesting its potential as a novel and effective topical therapeutic agent for the treatment of dermatitis including AD.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Chemistry, Medicinal
Huiwen Shi, Xiufen Jiang, Liudan Cao, Xing Peng, Qingyun Tan, Xifeng Teng, Qiong Gu, Lin He
Summary: Six new neoclerodane diterpenoids and ten known compounds were isolated from Ajuga forrestii. Their structures were determined by various analytical techniques. The structure of a known compound was revised based on NMR empirical rules. The compounds were evaluated for their inhibitory effect on RSL3-induced ferroptosis, and compounds 8, 9, and 12 showed significant inhibitory activity.
Article
Plant Sciences
Sungbae Park, Sangmin Lee, Youngho Weon, Taewook Kim, Hakwon Kim, Taehoon Lee
Summary: The study demonstrated that the traditional Asian medicinal herb extracts mixture (HM-V) exhibits inhibitory effects on pro-inflammatory cytokines induced by TNF-alpha and IFN-gamma, and displays anti-inflammatory properties in animal models. HM-V effectively inhibits the production of CCL17 and CCL22 by keratinocytes, suggesting its potential as an anti-inflammatory agent for the treatment of inflammatory skin diseases.
Article
Pharmacology & Pharmacy
Yubin Xu, Saizhen Chen, Lingling Zhang, Guirong Chen, Jinguang Chen
Summary: The study indicates that Huanglian Jiedu decoction can treat atopic dermatitis by regulating the antigen presentation function of dendritic cells, weakening T-lymphocyte activation, and subsequently exerting anti-inflammatory and anti-pruritus effects.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
JeongEun Kang, JiSun Park, Jung-Kil Seo, WonHyung Choi, SooCheol Choi, Ju-Hyoung Kim, In-Ah Lee
Summary: The study demonstrated that Ulva ohnoi oil has anti-inflammatory properties, reducing the production of nitric oxide and infiltration of inflammatory cells during inflammation, showing potential as an anti-inflammatory agent.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Hoon Kim, Hyun Young Shin, Eun-Jin Jeong, Hak-Dong Lee, Ki Cheol Hwang, Kwang-Won Yu, Sullim Lee, Sanghyun Lee
Summary: The present study investigated the potential of Sargassum macrocarpum as an anti-inflammatory candidate for inflammatory skin disease. The hot-water extract of S. macrocarpum demonstrated higher polyphenol content and stronger anti-inflammatory activity. Water-soluble materials may play a crucial role in the antioxidant and anti-inflammatory activity of S. macrocarpum.
Article
Pharmacology & Pharmacy
Mael Nicolas, Malia Lasalo, Sharron Chow, Cyril Antheaume, Karl Huet, Edouard Hnawia, Gilles J. Guillemin, Mohammed Nour, Mariko Matsui
Summary: In this study, the anti-inflammatory potential of ethanolic (ePE) and cyclohexane (cPE) extracts from Coleus forsteri on LPS-induced human macrophages models was investigated. The results showed that ePE and cPE extracts significantly inhibited the production of IL-6 and TNF-alpha, two inflammatory cytokines, in PMA-derived THP-1 macrophages. The production of QUIN, an inflammatory marker, was also reduced under ePE and cPE treatment in activated human monocyte-derived macrophages. Additionally, seven abietane diterpenes were identified from the cPE extract of C. forsteri, and their potential contributions to the anti-inflammatory activities were discussed.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Plant Sciences
Risako Kishimoto, Narumi Kato, Mayuka Koike, Naoki Iwashita, Yoshiichi Takagi, Tomoki Fukuyama
Summary: The study focused on developing preventive and supportive options for skin allergies using a natural product called Mastic. Results showed that topical treatment with mastic significantly improved inflammatory and pruritic responses in mouse models of allergic dermatitis and atopic dermatitis. Mastic treatment reduced skin thickness, AD score, transepidermal water loss, itch behavior, and pro-inflammatory cytokine production.
Review
Plant Sciences
Marcello Nicoletti
Summary: The therapeutic story of European mistletoe has had ups and downs. In ancient times, it was considered a panacea, but recent concerns about its toxicity led to doubts about its medicinal value. However, its selective action on tumor cells has brought back medical interest in mistletoe.
Article
Biotechnology & Applied Microbiology
Raimunda Samia Nogueira Brilhante, Raissa Geovanna Pereira Lopes, Lara de Aguiar, Jonathas Sales de Oliveira, Gessica Dos Santos Araujo, Germana Costa Paixao, Waldemiro De Aquino Pereira-Neto, Rosemayre Souza Freire, Joao Victor Serra Nunes, Renan Pereira de Lima, Flavia Almeida Santos, Jose Julio Costa Sidrim, Marcos Fabio Gadelha Rocha
Summary: The study evaluated the effect of proteinase K on dermatophyte biofilms and found that it reduced the metabolic activity and biomass of the biofilms. Additionally, proteinase K had synergistic interactions with terbinafine and griseofulvin, enhancing their activity against the biofilms.
Article
Multidisciplinary Sciences
Gerardo del Carmen Palacios-Saucedo, Lydia Guadalupe Rivera-Morales, Jose Manuel Vazquez-Guillen, Amilcar Caballero-Trejo, Melissa Carolina Mellado-Garcia, Aldo Sebastian Flores-Flores, Jose Alfredo Gonzalez-Navarro, Celia Geovana Herrera-Rivera, Luis Ernesto Osuna-Rosales, Julio Antonio Hernandez-Gonzalez, Ricardo Vazquez-Juarez, Carolina Barron-Enriquez, Ramon Valladares-Trujillo, Joaquin Dario Trevino-Baez, Cesar Alejandro Alonso-Tellez, Luis Daniel Ramirez-Calvillo, Ricardo Martin Cerda-Flores, Rocio Ortiz-Lopez, Miguel angel Rivera-Alvarado, Fortino Solorzano-Santos, Jorge Castro-Garza, Cristina Rodriguez-Padilla
Summary: This study investigated Group B Streptococcus (GBS) colonization in pregnant women from northeastern Mexico and found a low prevalence rate and no mother-to-child transmission. The study also identified virulence genes in the GBS strains and high levels of antibiotic resistance. The findings suggest that intentional screening for GBS colonization in this population may not be justified and highlight the importance of understanding antibiotic resistance patterns for GBS prevention and treatment.
Article
Biochemistry & Molecular Biology
Kesya Amanda Dantas Rocha, Tercio de Freitas Paulo, Alejandro Pedro Ayala, Valeria da Silva Sampaio, Paulo Iury Gomes Nunes, Flavia Almeida Santos, Kirley Marques Canuto, Edilberto Rocha Silveira, Otilia Deusdenia Loiola Pessoa
Summary: In this study, unknown Withajardin compounds and known tuboanosigenin were isolated from the leaves of Athenaea velutina. Their structures and absolute configurations were determined using various analytical techniques, and their anti-inflammatory activity was evaluated.
Article
Agriculture, Dairy & Animal Science
Paul McDermott, Aideen McKevitt, Flavia H. Santos, Alison J. Hanlon
Summary: Four options exist for the management of acutely injured cattle in Ireland: treatment, on-farm emergency slaughter (OFES), casualty slaughter (CS), or euthanasia. A survey of farmers revealed that most of them had a positive view of OFES, but there were concerns about the availability and cost of this option. Increasing availability and reducing cost of OFES could help decrease the number of cattle going for CS.
Article
Public, Environmental & Occupational Health
Fortino Solorzano-Santos, America Liliana Miranda-Lora, Horacio Marquez-Gonzalez, Miguel Klunder-Klunder
Summary: This study aimed to identify clinical and sociodemographic variables associated with COVID-19 mortality in pediatric patients using national open data and information from the Ministry of Health, Mexico. The results showed that the fatality rate of pediatric patients with COVID-19 is similar to that in other countries. Access to health services and the distribution of mortality were heterogeneous, and vulnerable groups included patients younger than 12 months and those with comorbidities.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Veterinary Sciences
Paul McDermott, Aideen McKevitt, Flavia H. Santos, Alison Hanlon
Summary: This study evaluated the perceptions of veterinarians in Ireland on the use of on-farm emergency slaughter (OFES) for the management of acutely injured cattle, and investigated the influence of capacity, willingness, and opportunity on their ability to operate OFES. The results showed that the availability of OFES was negatively associated with veterinarians' awareness of the procedure. Increasing the availability of OFES may help to improve the management of acutely injured cattle, particularly those with limb fractures that are unfit for transport.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Psychology, Educational
Fabiana Silva Ribeiro, Flavia H. Santos, Pedro B. Albuquerque
Summary: This study found that positive emotions evoked through music can temporarily enhance visuospatial working memory performance. Additionally, this is the first study to examine cognitive performance and physiological responses to musical stimuli simultaneously.
PSYCHOLOGY OF MUSIC
(2023)
Article
Chemistry, Medicinal
Luana San de O. Brito, Alison Batista, Flavia Almeida Santos, Renan Pereira de Lima, Alejandro Pedro Ayala, Kirley M. Canuto, Edilberto R. Silveira, Otilia Deusdenia L. Pessoa
Summary: Five new kaurane diterpenes (bezerraditerpenes A-E) and six known ones were isolated from the stems of Erythroxylum bezerrae. The structures of these compounds were determined by various spectroscopic methods. The anti-inflammatory potential of these diterpenes was evaluated on murine macrophage-like cells RAW 264.7, showing significant activity for compounds 1, 2, and 8 without cytotoxicity.
Article
Plant Sciences
Flavia Almeida Santos, Ana Flavia Seraine Custodio Viana, Paulo Iury Gomes Nunes, Benedito Yago Machado Portela, Ana Paula Negreiros Nunes Alves, Daniel de Araujo Viana, Kaline Rodrigues Carvalho, Rita de Cassia Alves Pereira, Paulo Riceli Vasconcelos Ribeiro, Elenilson Godoy Alves-Filho, Edy Sousa de Brito, Edilberto Rocha Silveira, Kirley Marques Canuto
Summary: This study evaluated the chemical composition and gastroprotective effect of flower bud infusions of Egletes viscosa. The infusions from two different chemotypes showed similar chemical compositions and exhibited a protective effect against gastric ulcers through antioxidant and antisecretory actions.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Rheumatology
Ana P. Sakamoto, Clovis A. Silva, Ana C. Pita, Vitor C. Trindade, Aline G. Islabao, Fernanda J. Fiorot, Sandra R. M. Lopes, Rosa M. R. Pereira, Claudia Saad-Magalhaes, Gleice C. S. Russo, Claudio A. Len, Rogerio do Prado, Lucia M. A. Campos, Nadia E. Aikawa, Simone Appenzeller, Virginia P. L. Ferriani, Marco F. Silva, Marta Felix, Adriana R. Fonseca, Ana P. L. Assad, Flavio R. Sztajnbok, Maria C. Santos, Blanca E. Bica, Evaldo G. Sena, Ana J. Moraes, Melissa M. Fraga, Teresa C. Robazzi, Paulo F. Spelling, Iloite M. Scheibel, Andre S. Cavalcanti, Erica N. Matos, Luciano J. Guimaraes, Flavia P. Santos, Licia M. H. Mota, Eloisa Bonfa, Maria T. Terreri
Summary: The objective of this study was to explore the associations between mortality in cSLE patients and their characteristics, as well as to evaluate the risk factors and determine the main causes of death. The results showed that the mortality rate in cSLE patients in Brazil was low, but neuropsychiatric lupus and chronic kidney disease were found to be significant risk factors for mortality.
Editorial Material
Geriatrics & Gerontology
Ted Kheng Siang Ng, Vanina Dal Bello-Haas, Ahmed Negm, Elena Philippou, Flavia H. Santos, Patricia C. Heyn
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Dentistry, Oral Surgery & Medicine
Lana Glerieide Silva Garcia, Maria Gleiciane da Rocha, Rosemayre Souza Freire, Paulo Iury Gomes Nunes, Joao Victor Serra Nunes, Mirele Rodrigues Fernandes, Waldemiro Aquino Pereira-Neto, Jose Julio Costa Sidrim, Flavia Almeida Santos, Marcos Fabio Gadelha Rocha, Lidiany Karla Azevedo Rodrigues, Rodrigo Silveira Vieira, Raimunda Samia Nogueira Brilhante
Summary: This study tested a drug delivery system based on chitosan microparticles loaded with geranium and lemongrass essential oils to inhibit the mixed biofilms of Candida albicans and Streptococcus mutans. The results showed that this system had good inhibitory effects on planktonic activity and reduced the metabolic activity of the biofilms.
JOURNAL OF APPLIED ORAL SCIENCE
(2023)
Article
Clinical Neurology
Bruna Rafaele Diogenes da Silva, Paulo Iury Gomes Nunes, Flavia Almeida Santos, Pedro Felipe Carvalhedo de Bruin, Veralice Meireles Sales de Bruin
Summary: Insufficient sleep disrupts lipid and glucose balance, while exercise can improve this metabolic dysfunction. Sleep deprivation and exercise have different effects on blood lipids and glucose, with exercise increasing cholesterol and decreasing triglycerides, while sleep deprivation has the opposite effect. Additionally, sleep deprivation significantly reduces hepatic triglycerides, but this effect can be prevented by exercise.
