mTORC2 Signaling Promotes Skeletal Growth and Bone Formation in Mice

mTORC1 signaling controls mammalian skeletal growth through stimulation of protein synthesis

(2014) Jianquan Chen et al.   DEVELOPMENT

Tsc2 Is a Molecular Checkpoint Controlling Osteoblast Development and Glucose Homeostasis

(2014) R. C. Riddle et al.   MOLECULAR AND CELLULAR BIOLOGY

WNT7B Promotes Bone Formation in part through mTORC1

(2014) Jianquan Chen et al.   PLoS Genetics

Adaptation of Tibial Structure and Strength to Axial Compression Depends on Loading History in Both C57BL/6 and BALB/c Mice

(2013) Nilsson Holguin et al.   CALCIFIED TISSUE INTERNATIONAL

WNT-LRP5 Signaling Induces Warburg Effect through mTORC2 Activation during Osteoblast Differentiation

(2013) Emel Esen et al.   Cell Metabolism

mTORC2 Regulates Mechanically Induced Cytoskeletal Reorganization and Lineage Selection in Marrow-Derived Mesenchymal Stem Cells

(2013) Buer Sen et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Development of the Endochondral Skeleton

(2013) F. Long et al.   Cold Spring Harbor Perspectives in Biology

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Hepatic mTORC2 Activates Glycolysis and Lipogenesis through Akt, Glucokinase, and SREBP1c

(2012) Asami Hagiwara et al.   Cell Metabolism

Mechanical Signaling for Bone Modeling and Remodeling

(2012) Alexander G. Robling et al.   CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION

Standardized nomenclature, symbols, and units for bone histomorphometry: A 2012 update of the report of the ASBMR Histomorphometry Nomenclature Committee

(2012) David W Dempster et al.   JOURNAL OF BONE AND MINERAL RESEARCH

β-catenin promotes bone formation and suppresses bone resorption in postnatal growing mice

(2012) Jianquan Chen et al.   JOURNAL OF BONE AND MINERAL RESEARCH

A unifying model for mTORC1-mediated regulation of mRNA translation

(2012) Carson C. Thoreen et al.   NATURE

Matrix IGF-1 maintains bone mass by activation of mTOR in mesenchymal stem cells

(2012) Lingling Xian et al.   NATURE MEDICINE

High-bone-mass-producing mutations in the Wnt signaling pathway result in distinct skeletal phenotypes

(2011) Paul J. Niziolek et al.   BONE

Tibial compression is anabolic in the adult mouse skeleton despite reduced responsiveness with aging

(2011) Maureen E. Lynch et al.   BONE

Sost downregulation and local Wnt signaling are required for the osteogenic response to mechanical loading

(2011) Xiaolin Tu et al.   BONE

Lrp5 functions in bone to regulate bone mass

(2011) Yajun Cui et al.   NATURE MEDICINE

Building strong bones: molecular regulation of the osteoblast lineage

(2011) Fanxin Long   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Insulin Receptor Signaling in Osteoblasts Regulates Postnatal Bone Acquisition and Body Composition

(2010) Keertik Fulzele et al.   CELL

Osteoblast Precursors, but Not Mature Osteoblasts, Move into Developing and Fractured Bones along with Invading Blood Vessels

(2010) Christa Maes et al.   DEVELOPMENTAL CELL

Cancellous bone adaptation to tibial compression is not sex dependent in growing mice

(2010) Maureen E. Lynch et al.   JOURNAL OF APPLIED PHYSIOLOGY

Aged mice have enhanced endocortical response and normal periosteal response compared with young-adult mice following 1 week of axial tibial compression

(2010) Michael D Brodt et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Guidelines for assessment of bone microstructure in rodents using micro-computed tomography

(2010) Mary L Bouxsein et al.   JOURNAL OF BONE AND MINERAL RESEARCH

BMP canonical Smad signaling through Smad1 and Smad5 is required for endochondral bone formation

(2009) K. N. Retting et al.   DEVELOPMENT

The Gli2 transcriptional activator is a crucial effector for Ihh signaling in osteoblast development and cartilage vascularization

(2009) K. S. Joeng et al.   DEVELOPMENT

mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

(2008) Juan M. García-Martínez et al.   BIOCHEMICAL JOURNAL

Targeted Deletion of the Sclerostin Gene in Mice Results in Increased Bone Formation and Bone Strength

(2008) Xiaodong Li et al.   JOURNAL OF BONE AND MINERAL RESEARCH