Article
Pharmacology & Pharmacy
Xiang Gao, Qingyun Wu, Xinle Zhang, Jia Tian, Dahong Liang, Yalin Min, Jiaqi Lu, Xuemei Zhang, Liao Cui, Bilian Xu, Yanzhi Liu
Summary: This study investigated the potential of salvianolate treatment in ameliorating osteopenia in prednisone-treated RA rats. The results showed that Salvianolate significantly improved bone density and bone quality.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Immunology
Qiong Wang, Qinbin Ye, Xiaoyu Xi, Xiaoxue Cao, Xing Wang, Mengxiao Zhang, Yuan Xu, Tingting Deng, Xiaobing Deng, Guoqiang Zhang, Cheng Xiao
Summary: This study explored the association between RIPK1-dependent necroptosis and the pathogenesis of rheumatoid arthritis (RA), and identified a potential new treatment option. The plasma levels of RIPK1 and MLKL were found to be higher in RA patients and positively correlated with disease severity. Treatment with KW2449, a small molecule inhibitor targeting RIPK1, reduced joint inflammation and tissue damage in an animal model of RA. These findings suggest that RIPK1-dependent necroptosis could be a therapeutic target for RA.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Orthopedics
Jianhai Chen, Jian Li, Jinqing Chen, Wenxiang Cheng, Jietao Lin, Liqing Ke, Gang Liu, Xueling Bai, Peng Zhang
Summary: The study demonstrated that the Notch signaling pathway inhibitor LY411575 is effective in treating collagen-induced arthritis (CIA) by improving the joint destruction and bone loss in rats. It also reduced the severity of ankle joint inflammation and significantly decreased the expression of N1ICD and N3ICD.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2021)
Article
Plant Sciences
Fangfang Xiang, Hongjuan Niu, Lan Yao, Jing Yang, Shuohan Cheng, Zhi Zhou, Refuhati Saimaiti, Yusup Matnur, Ainiwaer Talifu, Wenbin Zhou, Abliz Zeper
Summary: This study aimed to investigate the intervention effect of Munziq Balgam on collagen-induced arthritis (CIA) rats, discover potential biomarkers, and explore the metabolic regulation mechanisms. The results showed that Munziq Balgam effectively alleviated rheumatoid arthritis by regulating inflammation, immunity-related pathways, and multiple targets.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ju-Eun Hong, Chang-Gun Lee, Soonjae Hwang, Junyoung Kim, Minjeong Jo, Da-Hye Kang, Sang-Hyeon Yoo, Woo-Seung Kim, Yongheum Lee, Ki-Jong Rhee
Summary: This study found that pulsed electromagnetic field (PEMF) can alleviate inflammation in rheumatoid arthritis (RA), particularly at a frequency of 10 Hz. The treated mice had lower levels of joint inflammation and IL-1 beta. The results suggest that PEMF treatment can preserve joint morphology and delay the occurrence of RA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Zhengyu Fang, Yiping Hu, Jiajing Dai, Lianhua He, Juan He, Bihua Xu, Xinle Han, Fubo Zhong, Huiyao Lan, Qingwen Wang
Summary: The combination treatment with CS12192 and MTX is shown to have a better therapeutic effect on collagen-induced arthritis (CIA) in rats, with a stronger suppressive effect on T cells and macrophage-mediated joint inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Microbiology
Jiah Yeom, Dong Joon Yim, Seongho Ma, Young-Hee Lim
Summary: P. freudenreichii MJ2 inhibits osteoclast differentiation and improves rheumatoid arthritis in both in vitro and in vivo studies. Live and dead MJ2 showed similar therapeutic effects in the arthritis model.
Article
Food Science & Technology
Yunhui Min, Yunji Heo, Fang Feng, Dahye Kim, Mangeun Kim, Jiwon Yang, Hyo Jin Kim, Youngheun Jee, Mrinmoy Ghosh, Inhae Kang, Young-Ok Son
Summary: Excessive consumption of sucrose leads to hepatic fibrosis and inflammation, increasing the risk of rheumatoid arthritis (RA) pathogenesis.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Immunology
Yaling Tian, Ping Shi, Yan Zhou, Rui Yuan, Zhicheng Hu, Yan Tan, Guilan Ma, Lei Yang, Hongmei Jiang
Summary: The study successfully constructed tolDCs, and found that they had long-term tolerogenic potential in vivo, which could improve arthritis in CIA rats with different severity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Immunology
Lisheng Wu, Ran Wang, Yi Zhou, Di Zhao, Feilong Chen, Xianghui Wu, Xiaoguang Chen, Shixian Chen, Juan Li, Junqing Zhu
Summary: In rheumatoid arthritis, the infiltration of NK cells in the joints positively correlates with disease progression, inflammation, and bone destruction, but their pathogenic role may be independent of the NKp46 receptor.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Jing He, Yanan Chu, Jing Li, Qingren Meng, Yudong Liu, Jiayang Jin, Yifan Wang, Jian Wang, Bo Huang, Lianjie Shi, Xing Shi, Jiayi Tian, Yunzhi Zhufeng, Ruiling Feng, Wenjing Xiao, Yuzhou Gan, Jianping Guo, Changjun Shao, Yin Su, Fanlei Hu, Xiaolin Sun, Jun Yu, Yu Kang, Zhanguo Li
Summary: This study reveals the imbalance between butyrate-producing and butyrate-consuming species in rheumatoid arthritis patients. It shows that butyrate promotes the production of T-regs and reduces inflammation. Butyrate supplementation can alleviate inflammation by rebalancing immune cells and reducing antibody production.
Article
Immunology
Anqi Li, Zhanfeng Zhang, Xiaochen Ru, Yanfeng Yi, Xiaoyu Li, Jing Qian, Jue Wang, Xiaobing Yang, Yunliang Yao
Summary: Through gene expression analysis, a total of 1,885 up-regulated and 1,899 down-regulated DEGs were identified in RA samples. The analysis showed significant differences in the infiltration of 25 cells, and 603 immune-related genes were obtained through WGCNA, with 270 DEIRGs identified. Enrichment analysis indicated that DEIRGs were associated with immunity-related biological processes, and 4 candidate biomarkers were identified through the PPI network.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Takashi Nawata, Hiroki Sakai, Takeshi Honda, Marina Otsuka, Hina Fujita, Hitoshi Uchinoumi, Shigeki Kobayashi, Takeshi Yamamoto, Masataka Asagiri, Masafumi Yano
Summary: Dantrolene inhibits Ca2+ leakage from destabilized ryanodine receptors and shows potential as a therapeutic agent against endoplasmic reticulum stress-associated diseases. In a mouse model of collagen-induced arthritis, oral administration of dantrolene significantly reduces arthritic scores, suppresses bone and chondral destruction, and inhibits the production of serum anti-type II collagen IgG. These findings suggest that dantrolene may be a potential anti-rheumatic drug.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Zhenzhen Zhang, Jin Zhao, Kuan Chen Lai, Laijun Lai
Summary: The study found that TAPBPL protein can significantly ameliorate CII-induced arthritis in mice and reduce the expression of inflammatory cytokines. The results suggest that TAPBPL protein has the potential to be used in the treatment of patients with RA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Instruments & Instrumentation
Abhirami Thumsi, Srivatsan J. J. Swaminathan, Joslyn L. L. Mangal, Abhirami P. P. Suresh, Abhinav P. P. Acharya
Summary: The reprogramming of immune cells' metabolism can improve their function and reduce the severity of autoimmune diseases. In this study, a rheumatoid arthritis (RA) mouse model was developed to mimic immune flare-ups. The use of immune metabolic modulator paKG(PFK15 + bc2) microparticles (MPs) effectively reduced clinical symptoms of RA in mice.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)