期刊
BIOINFORMATICS
卷 28, 期 14, 页码 1818-1822出版社
OXFORD UNIV PRESS
DOI: 10.1093/bioinformatics/bts291
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资金
- National Institutes of Health/National Heart, Lung, and Blood Institute [T32 HL07183-34, R01 HL074745]
Motivation: Statistical analyses of genome-wide association studies (GWAS) require fitting large numbers of very similar regression models, each with low statistical power. Taking advantage of repeated observations or correlated phenotypes can increase this statistical power, but fitting the more complicated models required can make computation impractical. Results: In this article, we present simple methods that capitalize on the structure inherent in GWAS studies to dramatically speed up computation for a wide variety of problems, with a special focus on methods for correlated phenotypes.
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