期刊
BIOINFORMATICS
卷 28, 期 4, 页码 581-583出版社
OXFORD UNIV PRESS
DOI: 10.1093/bioinformatics/btr704
关键词
-
类别
资金
- National Institutes of Health, National Library of Medicine
CLARE is a computational method designed to reveal sequence encryption of tissue- specific regulatory elements. Starting with a set of regulatory elements known to be active in a particular tissue/process, it learns the sequence code of the input set and builds a predictive model from features specific to those elements. The resulting model can then be applied to user-supplied genomic regions to identify novel candidate regulatory elements. CLARE's model also provides a detailed analysis of transcription factors that most likely bind to the elements, making it an invaluable tool for understanding mechanisms of tissue- specific gene regulation.
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