期刊
BIOINFORMATICS
卷 27, 期 16, 页码 2296-2297出版社
OXFORD UNIV PRESS
DOI: 10.1093/bioinformatics/btr356
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类别
资金
- National Institute of Health (NIH) [HG002915]
- National Institute of Mental Health (NIMH) [MH074118]
Methyl-Analyzer is a python package that analyzes genome-wide DNA methylation data produced by the Methyl-MAPS ( methylation mapping analysis by paired-end sequencing) method. Methyl-MAPS is an enzymatic-based method that uses both methylation-sensitive and -dependent enzymes covering >80% of CpG dinucleotides within mammalian genomes. It combines enzymatic-based approaches with high-throughput next-generation sequencing technology to provide whole genome DNA methylation profiles. Methyl-Analyzer processes and integrates sequencing reads from methylated and unmethylated compartments and estimates CpG methylation probabilities at single base resolution.
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