The systems biology of mitochondrial fission and fusion and implications for disease and aging

On Circuit Functionality in Boolean Networks

(2013) Jean-Paul Comet et al.   BULLETIN OF MATHEMATICAL BIOLOGY

Mitochondrial Dynamics and Motility Inside Living Vascular Endothelial Cells: Role of Bioenergetics

(2012) Randy J. Giedt et al.   ANNALS OF BIOMEDICAL ENGINEERING

Mitochondria: In Sickness and in Health

(2012) Jodi Nunnari et al.   CELL

Energy transfer in "parasitic" cancer metabolism

(2012) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

Upregulated function of mitochondria-associated ER membranes in Alzheimer disease

(2012) Estela Area-Gomez et al.   EMBO JOURNAL

The intracellular redox state is a core determinant of mitochondrial fusion

(2012) Timothy Shutt et al.   EMBO REPORTS

Mitochondrial morphology—emerging role in bioenergetics

(2012) Chad A. Galloway et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondrial Fission, Fusion, and Stress

(2012) R. J. Youle et al.   SCIENCE

Emergence of the Mitochondrial Reticulum from Fission and Fusion Dynamics

(2012) Valerii M. Sukhorukov et al.   PLoS Computational Biology

Deceleration of Fusion–Fission Cycles Improves Mitochondrial Quality Control during Aging

(2012) Marc Thilo Figge et al.   PLoS Computational Biology

Mitochondrial Variability as a Source of Extrinsic Cellular Noise

(2012) Iain G. Johnston et al.   PLoS Computational Biology

Measuring and Modeling Apoptosis in Single Cells

(2011) Sabrina L. Spencer et al.   CELL

Cellular Decision Making and Biological Noise: From Microbes to Mammals

(2011) Gábor Balázsi et al.   CELL

The importance of mitochondrial fusion in aging

(2011) Cristina Mazzoni et al.   CELL CYCLE

Regulation of mammalian cell cycle progression in the regenerating liver

(2011) Anuradha Chauhan et al.   JOURNAL OF THEORETICAL BIOLOGY

Overexpression of PGC-1β improves insulin sensitivity and mitochondrial function in 3T3-L1 adipocytes

(2011) Chun-Lin Gao et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Mitochondria unite to survive

(2011) Craig Blackstone et al.   NATURE CELL BIOLOGY

During autophagy mitochondria elongate, are spared from degradation and sustain cell viability

(2011) Ligia C. Gomes et al.   NATURE CELL BIOLOGY

Control of Mitochondrial Morphology Through Differential Interactions of Mitochondrial Fusion and Fission Proteins

(2011) Pinwei Huang et al.   PLoS One

Evolution of the mitochondrial fusion-fission cycle and its role in aging

(2011) A. Kowald et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Taking a “good” look at free radicals in the aging process

(2011) Siegfried Hekimi et al.   TRENDS IN CELL BIOLOGY

Dynamic regulation of mitochondrial fission through modification of the dynamin-related protein Drp1

(2010) Chuang-Rung Chang et al.   Annals of the New York Academy of Sciences

Mitochondrial function, mitochondrial DNA and ageing: a reappraisal

(2010) Giuseppe Passarino et al.   BIOGERONTOLOGY

Autoregulation of Free Radicals via Uncoupling Protein Control in Pancreatic β-Cell Mitochondria

(2010) William J. Heuett et al.   BIOPHYSICAL JOURNAL

New insights into the role of mitochondria in aging: mitochondrial dynamics and more

(2010) A. Y. Seo et al.   JOURNAL OF CELL SCIENCE

Mitochondrial fusion and fission in cell life and death

(2010) Benedikt Westermann   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Spatio-temporal oscillations of individual mitochondria in cardiac myocytes reveal modulation of synchronized mitochondrial clusters

(2010) F. T. Kurz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glucose sensing in the pancreatic beta cell: a computational systems analysis

(2010) Leonid E Fridlyand et al.   Theoretical Biology and Medical Modelling

Magnitude and control of mitochondrial sensitivity to ADP

(2009) Jeroen A. L. Jeneson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Ca2+ transfer from the ER to mitochondria: When, how and why

(2009) Rosario Rizzuto et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Frequency and Selectivity of Mitochondrial Fusion Are Key to Its Quality Maintenance Function

(2009) Pradeep K. Mouli et al.   BIOPHYSICAL JOURNAL

Defining Network Topologies that Can Achieve Biochemical Adaptation

(2009) Wenzhe Ma et al.   CELL

Mitochondrial ‘kiss-and-run’: interplay between mitochondrial motility and fusion–fission dynamics

(2009) Xingguo Liu et al.   EMBO JOURNAL

Does mtDNA nucleoid organization impact aging?

(2009) Daniel F. Bogenhagen   EXPERIMENTAL GERONTOLOGY

Qualitatively distinct phenotypes in the design space of biochemical systems

(2009) Michael A. Savageau et al.   FEBS LETTERS

Role of mitochondrial dynamics proteins in the pathophysiology of obesity and type 2 diabetes

(2009) Antonio Zorzano et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Phenotypes and tolerances in the design space of biochemical systems

(2009) M. A. Savageau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Models for the Generation and Interpretation of Gradients

(2009) H. Meinhardt   Cold Spring Harbor Perspectives in Biology

Stochastic Drift in Mitochondrial DNA Point Mutations: A Novel Perspective Ex Silico

(2009) Suresh Kumar Poovathingal et al.   PLoS Computational Biology

Bistability, Epigenetics, and Bet-Hedging in Bacteria

(2008) Jan-Willem Veening et al.   Annual Review of Microbiology

The role of mitochondria in aging of skeletal muscle

(2008) Pedro Alexandre Figueiredo et al.   BIOGERONTOLOGY

Mitochondrial fission and fusion dynamics: the long and short of it

(2008) S B Berman et al.   CELL DEATH AND DIFFERENTIATION

Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

(2008) Gilad Twig et al.   EMBO JOURNAL

The mitochondrial outer membrane protein hFis1 regulates mitochondrial morphology and fission through self-interaction

(2008) Madhavika N. Serasinghe et al.   EXPERIMENTAL CELL RESEARCH

Mitochondrial dynamics and apoptosis

(2008) D.-F. Suen et al.   GENES & DEVELOPMENT

Biological switches and clocks

(2008) J. J Tyson et al.   Journal of the Royal Society Interface

Design principles of biochemical oscillators

(2008) Béla Novák et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Selective Adaptation in Networks of Heterogeneous Populations: Model, Simulation, and Experiment

(2008) Avner Wallach et al.   PLoS Computational Biology

Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria

(2008) G. M. Cereghetti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA