Article
Anthropology
Alexandra Wulff, Clare McFadden
Summary: This study found that there was no significant relationship between localised hypoplasia of the primary canine (LHPC) lesions and mortality in a late prehistoric Thai sample. However, subsequent tests revealed that the impact of LHPC on subadult mortality in late prehistoric Thailand was likely guided by the prevalence of LHPC at a site. The findings suggest that the relationship between LHPC, physiological stress, and mortality was complex and context dependent in late prehistoric Southeast Asia.
JOURNAL OF ARCHAEOLOGICAL SCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Hisanori Fukunaga
Summary: Mitochondrial dysfunction is closely related to disease, and environmental factors during fetal life may influence health risks in offspring.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Chien-Ning Hsu, You-Lin Tain
Summary: The developmental origins of health and disease theory suggests that many adult-onset diseases can originate in early life. Oxidative stress plays a crucial role in renal programming, and perinatal use of antioxidants can reverse programming processes and prevent adult-onset diseases.
Review
Biochemistry & Molecular Biology
Chien-Ning Hsu, You-Lin Tain
Summary: The cardiovascular system can be programmed by early-life insults, potentially leading to cardiovascular disease in adulthood. Hydrogen sulfide plays a crucial role in the pathogenesis of cardiovascular disease of developmental origins, with early interventions based on H2S showing benefits in preventing adult-onset CVD. Understanding cardiovascular programming and recent advances in H2S-based interventions may help lower the global burden of CVD.
Review
Biochemistry & Molecular Biology
Chien-Ning Hsu, You-Lin Tain
Summary: Animal models are essential for investigating the causal relationship between early-life exposure and the developmental programming of hypertension, providing insights into how early interventions can reprogram disease processes and prevent hypertension.
Review
Biochemistry & Molecular Biology
You-Lin Tain, Chien-Ning Hsu
Summary: Hypertension is a significant global disease burden and can originate in early life. Melatonin, a hormone with multifaceted biological functions, plays important roles in pregnancy, fetal development, and blood pressure regulation. Early melatonin therapy as a reprogramming strategy can protect against the early life origins of hypertension.
Review
Genetics & Heredity
Salvo Danilo Lombardo, Ivan Fernando Wangsaputra, Jorg Menche, Adam Stevens
Summary: This article highlights the importance of the early developmental phase for human health and disease, focusing on the integration and analysis methods for studying transcriptomic and epigenetic processes relevant to the periconceptional period.
Review
Nutrition & Dietetics
Michael D. Thompson, Brian J. DeBosch
Summary: With the increasing consumption of fructose in the diet, the impact of fructose exposure during pregnancy and lactation has gained significance. While human studies have established the effect of fructose consumption on maternal health, little is known about its impact on offspring. Animal models have shown an association between maternal fructose exposure and chronic diseases in offspring.
Review
Endocrinology & Metabolism
Hiroaki Itoh, Megumi Ueda, Misako Suzuki, Yukiko Kohmura-Kobayashi
Summary: Metabolic syndrome, associated with obesity, increases the risk of type 2 diabetes, coronary diseases, stroke, and other disabilities. The Developmental Origins of Health and Disease (DOHaD) theory suggests that early developmental environmental imbalance affects health and predisposes individuals to non-communicable diseases, including metabolic syndrome. The 'Thrifty Phenotype' hypothesis proposes that undernourished fetuses develop evolutionary advantageous traits for survival in a hangry environment after birth, but this phenotype increases the risk of metabolic syndrome under an obesogenic diet. Chronic inflammation, referred to as 'Metaflammation', is believed to mediate the connection between obesity and metabolic disorders in metabolic syndrome. However, the contribution of evolutionary maladaptation to the pathophysiology of 'Metaflammation' remains understudied. Investigating 'Metaflammation' from the perspective of selective advantages and mismatches to contemporary lifestyles can provide valuable insights, considering the concept of evolutionarily conserved nutrient sensing and immune signaling systems.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
You-Lin Tain, Chien-Ning Hsu
Summary: This review discusses the innovative use of animal models in studying the mechanisms behind developmental origins of hypertension. Research has found that early maternal stress can alter the gut microbiota, leading to adverse outcomes in offspring. Dysbiosis of the gut microbiota is involved in the developmental origins of hypertension, while targeted therapy for the gut microbiota can prevent hypertension in later life.
Review
Geriatrics & Gerontology
Yaqin Wei, Shuang Jia, Yuanyuan Ding, Shijin Xia, Sergio Giunta
Summary: Both reactive oxygen species (ROS) and pro-inflammatory cytokines play important physiological roles as signaling molecules in maintaining adaptive homeostasis during aging. In the early phases of mild environmental imbalances, these components act as low-grade warning signals for homeostatic stability. Persistent disturbances can lead to oxidative stress and overt-inflammaging, increasing the risks of aging-related diseases. However, low levels of ROS and pro-inflammatory cytokines can prevent or slow down the decline of adaptive homeostasis, serving as potential pillars in aging.
EXPERIMENTAL GERONTOLOGY
(2023)
Article
Biochemistry & Molecular Biology
You-Lin Tain, Chien-Ning Hsu
Summary: Oxidative stress plays a crucial role in the developmental origins of hypertension, as early-life oxidative stress leads to developmental programming in key blood pressure-controlled organs and subsequently results in hypertension in adulthood. Antioxidant therapy has the potential to lower blood pressure and serves as a novel preventive strategy for hypertension with developmental origins.
Article
Pediatrics
Erika Hagemann, Desiree T. Silva, Jacqueline A. Davis, Lisa Y. Gibson, Susan L. Prescott
Summary: Interventional birth cohorts are focusing on optimizing health potential of individuals and communities, beyond disease prevention, by examining factors such as nature relatedness, interpersonal relationships, mindfulness, and positive emotions. They aim to influence core behaviors through better relationships with self, community, and the environment, with the goal of achieving positive change in every community.
PAEDIATRIC RESPIRATORY REVIEWS
(2021)
Review
Endocrinology & Metabolism
Chien-Ning Hsu, You-Lin Tain
Summary: To reduce the global burden of kidney disease and hypertension, urgent action is needed to identify toxic chemicals in the environment, avoid harmful chemical exposure during pregnancy and lactation, and translate effective reprogramming interventions from animal studies into clinical practice.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Cell Biology
Johan K. Lassen, Tingting Wang, Kirstine L. Nielsen, Jorgen B. Hasselstrom, Mogens Johannsen, Palle Villesen
Summary: Untargeted metabolomics is used to study all detectable small molecules. In this study, the analysis of biological age was conducted on approximately 10,000 toxicologic routine blood measurements. A custom neural network model was developed to predict chronological age and identified compounds related to biological age. The results validate the association of tryptophan and acylcarnitine metabolism with aging.
Article
Dentistry, Oral Surgery & Medicine
Heitor Sales de Barros Santos, Thuy Do, Clarissa Cavalcanti Fatturi Parolo, Joice de Faria Poloni, Marisa Maltz, Rodrigo Alex Arthur, Naile Dame-Teixeira
Summary: This study investigated the gene expression and functional profile of Streptococcus mutans in biofilms from sound root surfaces (SRS) and carious root surfaces (RC). The results showed that there were differentially expressed genes between SRS and RC, with a greater functional abundance of S. mutans in the carious lesion samples. Functional patterns related to sugar metabolism, cell-wall biosynthesis, and acid tolerance stress were enriched on carious root surfaces.
Article
Infectious Diseases
Bruno Cesar Feltes, Igor Araujo Vieira, Jorge Parraga-Alava, Jaime Meza, Edy Portmann, Luis Teran, Marcio Dorn
Summary: This study used machine learning techniques to compare CBC data between Brazil and Ecuador, two genetically distinct Latin American countries. The findings showed a clear distribution pattern of positive and negative cases between the two countries, with almost all red blood cell count parameters being different.
INFECTION GENETICS AND EVOLUTION
(2022)
Article
Computer Science, Interdisciplinary Applications
Itamar Jose Guimaraes Nunes, Bruno Cesar Feltes, Murilo Zanini David, Marcio Dorn
Summary: This study presents a new R package called GEVA, which can analyze multiple gene expression datasets and identify genes with consistent differential expression across experiments. GEVA takes multiple differential expression analysis results as input and performs weighted summarization, partitioning, and clustering to find genes that vary less across experiments. The package also allows grouping of experimental conditions into factors, and performs additional statistical tests to identify genes specifically or dependently expressed in response to these factors. Results from the package were validated using knockout studies and were found to be consistent with published experimental studies. GEVA provides a robust alternative for multiple comparison analyses.
JOURNAL OF BIOMEDICAL INFORMATICS
(2022)
Article
Biotechnology & Applied Microbiology
Bruno Cesar Feltes, Carlos Frederico Martins Menck
Summary: POL eta is a crucial protein involved in replicating damaged DNA and is associated with cancer and xeroderma pigmentosum variant. Understanding its structure is important for biomedical sciences and it has the potential to be a targeted therapy for tumors.
MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Tamie Duarte, Monica de Medeiros Silva, Paula Michelotti, Nilda Berenice de Vargas Barbosa, Bruno Cesar Feltes, Marcio Dorn, Joao Batista Teixeira da Rocha, Cristiane Lenz Dalla Corte
Summary: This study investigated the effects of two hypercaloric diets and aging on the expression levels of ACE2 genes in fruit flies, and analyzed the binding affinity between fruit fly ACE2 and the Spike protein. The results showed that the expression of Ance and Acer genes in adult fruit flies is influenced by diet and age, and that Ance and Acer proteins can interact with the Spike protein in different regions.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Article
Genetics & Heredity
Gabriela Flores Goncalves, Joice de Faria Poloni, Marcio Dorn
Summary: This study investigated the association between lncRNAs and host response to C. albicans infection. By analyzing a public RNA-Seq dataset, the researchers identified lncRNAs related to biological processes involved in immune response and reactive species production. These findings provide new insights into the functions of lncRNAs in the immune response.
Review
Genetics & Heredity
Regis Antonioli Junior, Joice de Faria Poloni, Ederson Sales Moreira Pinto, Marcio Dorn
Summary: Biosurfactants are amphipathic molecules that can lower interfacial and superficial tensions. They are biodegradable and have a wide diversity of categories, with lipopeptides being the most abundant and well-known. Protein-containing biosurfactants are less studied but could be a valuable alternative. Understanding the harsh conditions that target organisms can sustain is crucial for successful implementation. This article explores the biotechnological applications of lipopeptide and protein-containing biosurfactants, as well as their natural role and the potential research possibilities using meta-omics and machine learning.
Article
Chemistry, Multidisciplinary
Bruno Cesar Feltes, Ederson Sales Moreira Pinto, Arthur Tonietto Mangini, Marcio Dorn
Summary: The NIAS server is a tool that analyzes the conformational preferences of amino acids in proteins. It is based on the Angle Probability List and integrates structural information from the Protein Data Bank. The updated NIAS server includes data from various experimental techniques and provides examples of its application in structural biology research, as well as discussions on its limitations.
JOURNAL OF COMPUTATIONAL CHEMISTRY
(2023)
Article
Medicine, Research & Experimental
Joice de Faria Poloni, Bruno Cesar Feltes
Summary: Homeobox genes play important roles in developmental and cancer biology, and understanding their regulation is crucial in various molecular pathways. Exitrons, also known as intronic exons, are new players in transcriptional organization, providing additional splicing variants with unknown functions. This article introduces perspectives for exploring the role of exitron-containing transcriptional isoforms in the context of tumorigenesis for homeobox genes HOXA1, HOXA9, HOXD8, NKX3.1, and DLX6.
WIRES MECHANISMS OF DISEASE
(2023)
Review
Genetics & Heredity
Ederson Sales Moreira Pinto, Mathias J. Krause, Marcio Dorn, Bruno Cesar Feltes
Summary: Understanding the molecular behavior of proteins involved in the nucleotide excision repair pathway is crucial for studying related diseases and the organization of the pathway. Molecular dynamics techniques can provide insights into the dynamic nature of biomolecules. However, there is still a lack of widespread molecular dynamics studies on DNA repair pathways.
Article
Biochemistry & Molecular Biology
Regis Antonioli Junior, Joice de Faria Poloni, Manuel Riveros A. Escalona, Marcio Dorn
Summary: Crude oil contamination poses a significant threat to the environment and biodiversity. However, certain microorganisms in contaminated areas can utilize hydrocarbons as a source of nutrients, highlighting the importance of understanding local community dynamics in these environments. Through the analysis of genetic and functional data, we identified the prevalence of hydrocarbon-degrading functionality in contaminated sediments and potential targets for bioremediation.
Article
Biochemistry & Molecular Biology
Manuel Adrian Riveros Escalona, Joice de Faria Poloni, Mathias J. Krause, Marcio Dorn
Summary: Colorectal cancer is commonly associated with changes in the gut microbiota, and recent studies have provided a better understanding of the specific species related to its development. However, the importance of certain species and their interactions across different datasets still needs further exploration.
Article
Dentistry, Oral Surgery & Medicine
Lais Daniela Ev, Joice de Faria Poloni, Naile Dame-Teixeira, Rodrigo Alex Arthur, Daniela Jorge Corralo, Sandra Liana Henz, Thuy Do, Marisa Maltz, Clarissa Cavalcanti Fatturi Parolo
Summary: This study evaluated the microbial functional profile of biofilms related to different clinical conditions related to caries or health. Metatranscriptomic analysis identified specific genes and gene modules strongly related to caries status, and gene ontology analysis revealed important bioprocesses related to caries-free conditions.
CLINICAL ORAL INVESTIGATIONS
(2023)
Article
Biotechnology & Applied Microbiology
Bruno Cesar Feltes, Carlos Frederico Martins Menck
Summary: POL eta, encoded by the POLH gene, is a crucial protein involved in replicating damaged DNA and is a widely studied specialized translesion synthesis polymerase. Mutations in POL eta are associated with cancer and the human syndrome xeroderma pigmentosum variant. Understanding its structure is crucial for biomedical sciences due to its essential role in cell survival and its potential as a targeted therapy-drug for tumors.
MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH
(2022)