Article
Biochemistry & Molecular Biology
Yaoru Yu, Jing Chen, Lu An, Tianci Huang, Wenbo Wang, Ziqi Cheng, Lu Wang, Xuesong Xu, Zhizhuang Zhao, Xueqi Fu, Junfeng Ma
Summary: By investigating the structure and biological functions of phosphatases in C. elegans, it was found that suppression of PRL-1 prolonged the lifespan and improved the healthspan of the worms. This effect is mediated through a DAF-16-dependent pathway and is associated with reduced levels of reactive oxygen species (ROS).
Article
Cell Biology
Zhimin Qi, Huihui Ji, Monika Le, Hanmei Li, Angela Wieland, Sonja Bauer, Li Liu, Michael Wink, Ingrid Herr
Summary: Sulforaphane extends the lifespan of C. elegans by modulating the insulin/IGF-1 signaling pathway, promoting healthspan by increasing mobility and appetite while reducing lipofuscin accumulation.
Article
Cell Biology
Huihui Ji, Zhimin Qi, Daniel Schrapel, Monika Le, Yiqiao Luo, Bin Yan, Jury Gladkich, Michael Schaefer, Li Liu, Ingrid Herr
Summary: Sulforaphane can prolong lifespan and healthspan by inducing the expression and nuclear translocation of TRA-1/GLI, and thus support healthy aging by regulating daf-16/FOXO. However, the prolonging effects of sulforaphane on lifespan and healthspan are inhibited when TRA-1 or daf-16 is interfered with by RNA interference or using worms with mutants of tra-1 or daf-16 genes.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xiang Xiao, Yurong Zhou, Cui Tan, Juan Bai, Ying Zhu, Jiayan Zhang, Xinghua Zhou, Yansheng Zhao
Summary: Barley beta-glucan shows potential in defending oxidative stress in C. elegans by reducing ROS levels, enhancing SOD and CAT enzyme activity, decreasing MDA content, and extending lifespan. It participates in anti-oxidative stress partially through the daf-2/daf-16 pathway.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Medicine, Research & Experimental
Yixin Liu, Wenyan She, Yi Li, Miao Wang, Yin Liu, Biao Ning, Tianzi Xu, Tianhe Huang, Yongchang Wei
Summary: This study investigates the therapeutic efficiency of a novel organo-arsenic compound Aa-Z2 targeting metabolism in osteosarcoma. Aa-Z2 induces apoptosis, G2/M phase arrest, and autophagy in osteosarcoma cells through the accumulation of reactive oxygen species (ROS). Furthermore, Aa-Z2 alters mitochondrial membrane potential and glucose metabolism by targeting pyruvate dehydrogenase kinase 1 (PDK-1) to accumulate ROS. Overall, this study reveals the mechanism of Aa-Z2-related metabolic alterations in osteosarcoma inhibition and provides pharmacologic evidence for the development of metabolism-targeting therapeutics.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Maria Alejandra Guerrero-Rubio, Samanta Hernandez-Garcia, Francisco Garcia-Carmona, Fernando Gandia-Herrero
Summary: Flavonoids, potential nutraceutical compounds found in dairy food, are considered health-promoting compounds with promising therapeutic effects on neurological, inflammatory diseases, diabetes, and cancer. In Caenorhabditis elegans, chrysin, 6-hydroxyflavone, and baicalein were found to significantly extend lifespan, with effects mediated by different signaling pathways. Microarray analysis showed that baicalein downregulates important age-related genes such as mTOR and PARP.
Article
Immunology
Yi Xiao, Li Zhang, Xinting Zhu, Ying Qin, Changyan Yu, Nian Jiang, Sanhua Li, Fang Liu, Yun Liu
Summary: The DAF-2/DAF-16 insulin-like signaling pathway regulates various aspects of organismal physiology and is conserved throughout evolution. Luteolin, a flavone found in many plants and vegetables, has been shown to have anti-tumor, antioxidant, and neuroprotective effects. This study found that luteolin increased resistance to both Gram-negative and Gram-positive pathogens in a dose-dependent manner and promoted host immune response. Furthermore, it was discovered that luteolin activated the DAF-16/FOXO transcription factor and promoted innate immunity through the DAF-2/DAF-16 insulin-like signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jiahao Zhu, Yumei Jia, Cong Wang, Wangting Zhou, Yifan Shu, Kaixin Zhang, Xiaoxiong Zeng, Renpeng Guo
Summary: This study investigated the anti-aging activities of Lonicera japonica polysaccharides (LJPs) and revealed their mechanism of action. LJPs were found to prolong the lifespan of Caenorhabditis elegans, improve its fitness, reduce lipofuscin accumulation, and activate stress-related genes and antioxidant system. These effects were mediated by the DAF-16 pathway.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Fangru Wang, Ting Jin, Hongyuan Li, Houfang Long, Ying Liu, Sha Jin, Yuyuan Lu, Yinghua Peng, Cong Liu, Lihui Zhao, Xiaohui Wang
Summary: Cannabidivarin (CBDV), a structural analog of cannabidiol (CBD), inhibits the aggregation of alpha-synuclein (alpha-syn) and protects DAergic neurons from oxidative stress and degeneration in a Caenorhabditis elegans model. The phenolic hydroxyl groups of CBDV are essential for its antioxidant activity and the prevention of alpha-syn aggregation.
Article
Pharmacology & Pharmacy
Lin Tan, Zhuo-Ya Zheng, Lv Huang, Zhong Jin, Su-Lian Li, Gui-Sheng Wu, Huai-Rong Luo
Summary: This study found that Complanatoside A (CA) could extend the lifespan of Caenorhabditis elegans and improve their physiological functions. CA also reduced the accumulation of toxic proteins and delayed the onset of neurodegenerative disorders. The study suggested that CA is a potential antiaging agent worth further research.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Food Science & Technology
Yali Wang, Yidan Sun, Xingguo Wang, Yue Wang, Langxing Liao, Yonghui Zhang, Baishan Fang, Yousi Fu
Summary: Two novel collagen peptides derived from Yak bones, UU1 and K7, were found to have antioxidative effects in vitro and in Caenorhabditis elegans. They extended the survival time, promoted reproduction, attenuated the accumulations of reactive oxygen species and malondialdehyde, and enhanced the activities of superoxide dismutase and catalase in worms.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Environmental Sciences
Chi-Wei Huang, Wan-Ru Liao, Chun Ming How, Pei-Ling Yen, Chia-Cheng Wei
Summary: The study found that ZEN significantly decreased locomotive behaviors in C. elegans. Lifespan and aging markers were also adversely affected by ZEN, which increased ROS levels and downregulated antioxidant genes. Long-term exposure to ZEN induced aging-related decline in C. elegans, associated with oxidative stress and inhibition of antioxidant defense.
ENVIRONMENTAL POLLUTION
(2021)
Article
Pharmacology & Pharmacy
Zhenghan Dong, Yachao Wang, Cuiting Hao, Yuan Cheng, Xi Guo, Yanyu He, Yueyue Shi, Shuang Wang, Yunqi Li, Wei Shi
Summary: This study found that the extract of S. Sanghuang (SSE) has positive effects on nematode indicators. Different concentrations of SSE can prolong the lifespan of nematodes and increase it by 26.41%. SSE also reduces the accumulation of endogenous aging substances, increases antioxidant capacity and enhances physical fitness. RT-PCR analysis shows that SSE treatment upregulates the expression of a series of genes, prolonging the lifespan of nematodes. This study reveals the new role of S. Sanghuang in promoting longevity and inhibiting stress, providing a theoretical basis for its application in anti-aging treatments.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Myogyeong Cho, Yebin Kim, Sohyeon You, Dae Youn Hwang, Miran Jang
Summary: To assess the potential of Cirsium japonicum (CJ) as a functional food material, the functional composition of cultivated CJ and the antioxidant activity of its functional substance were studied. Chlorogenic acid (CA), linarin (LIN), and pectolinarin (PLIN) were identified in farmed CJ by HPLC analysis. CA exhibited the strongest antioxidant activity. The benefits of CA were confirmed in Caenorhabditis elegans, where it delayed aging-related declines in pumping rate and progeny production, reduced reactive oxygen species (ROS) production, and increased lifespan through the actions of daf-16 or skn-1 depending on the degree of oxidation or aging. These findings suggest that CJ containing CA can be used as an antiaging material due to its antioxidant properties.
Article
Biochemistry & Molecular Biology
Abdel Fawaz Bagoudou, Yifeng Zheng, Masahiro Nakabayashi, Saroat Rawdkuen, Hyun-Young Park, Dhiraj A. Vattem, Kenji Sato, Soichiro Nakamura, Shigeru Katayama
Summary: The study identified the neuroprotective activity of Glochidion littorale leaf extract, which showed high bioactivities in ameliorating oxidative stress and protecting against neurodegeneration in Caenorhabditis elegans. The observed effects may be associated with the activation of the transcription factor DAF-16, and potential key phenolic compounds identified in the extract include myricetin, coumestrin, chlorogenic acid, and hesperidin. This novel neuroprotective activity of GLE may be utilized in developing treatments for neurodegenerative diseases like Parkinson's syndrome.
Article
Plant Sciences
Miseon Kim, Young-Su Yi, Juewon Kim, Sang Yun Han, Su Hwan Kim, Dae Bang Seo, Jae Youl Cho, Song Seok Shin
JOURNAL OF GINSENG RESEARCH
(2018)
Article
Plant Sciences
Sang Yun Han, Juewon Kim, Eunji Kim, Su Hwan Kim, Dae Bang Seo, Jong-Hoon Kim, Song Seok Shin, Jae Youl Cho
JOURNAL OF GINSENG RESEARCH
(2018)
Article
Plant Sciences
Jeong-Ook Lee, Eunji Kim, Ji Hye Kim, Yo Han Hong, Han Gyung Kim, Deok Jeong, Juewon Kim, Su Hwan Kim, Chanwoong Park, Dae Bang Seo, Young-Jin Son, Sang Yun Han, Jae Youl Cho
JOURNAL OF GINSENG RESEARCH
(2018)
Article
Plant Sciences
Han Seok Choi, Sunmi Kim, Min Jung Kim, Myung-Sunny Kim, Juewon Kim, Chan-Woong Park, Daebang Seo, Song Seok Shin, Sang Woo Oh
JOURNAL OF GINSENG RESEARCH
(2018)
Article
Dermatology
Juewon Kim, Toshihiko Toda, Kenji Watanabe, Shuichi Shibuya, Yusuke Ozawa, Naotaka Izuo, Siyoung Cho, Dae Bang Seo, Koutaro Yokote, Takahiko Shimizu
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Juewon Kim, Shinichiro Funayama, Naotaka Izuo, Takahiko Shimizu
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
(2019)
Article
Dermatology
Juewon Kim, Young-Gyu Kang, Dong-hwa Choi, Young-uk Cho, Si-young Cho, Hyunjung Choi, Hyoung-June Kim
EXPERIMENTAL DERMATOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Ji Young Lee, Jooyun Lee, Daejin Min, Juewon Kim, Hyoung-June Kim, Kyoung Tai No
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Ji Young Lee, Juewon Kim, Yeon Joo Nam, Hyoung-june Kim, Kyoung Tai No
Summary: Effective and safe skin depigmentation compounds have been identified in the cosmetic and pharmaceutical industries, with inhibition of tyrosinase being one of the most effective methods. Isolindleyin, a novel tyrosinase inhibitor, was found to suppress melanin synthesis by directly binding to tyrosinase and stabilizing the binding through hydrophobic interactions and hydrogen bonds at the active sites. This study highlights the anti-melanogenic effects of isolindleyin in overcoming dermatological concerns related to abnormal melanin synthesis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Juewon Kim, Jeongin Lee, Hyunjung Choi
Summary: The study found that intense pulsed light (IPL) treatment helps alleviate the photoaged phenotype of skin cells induced by UVB, reducing excessive cutaneous immune reactions by suppressing proinflammatory cytokine expression. Combined treatment with green and yellow IPL synergistically attenuates hyperpigmentation and excessive immune response.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Dermatology
J. Kim, H. Choi
Summary: The study found that several mucin proteins are expressed in human skin cells, among which MUCL1 has the highest expression and a clear negative correlation with melanin production in epidermal melanocytes. The research revealed a novel mechanism of mucin regulation with diagnostic and preventive roles of MUCL1 in cutaneous melanoma, suggesting an association between MUCL1, threonine, melanogenesis, and metastasis-related genes in melanoma cells.
BRITISH JOURNAL OF DERMATOLOGY
(2022)
Article
Multidisciplinary Sciences
Juewon Kim, Yunju Jo, Donghyun Cho, Dongryeol Ryu
Summary: This study reveals the role of L-threonine as a crucial mediator in dietary restriction, preventing age-induced ferroptosis and promoting healthy aging.
NATURE COMMUNICATIONS
(2022)
Article
Medicine, Research & Experimental
Juewon Kim, Hyung-Su Kim, Dong-Hwa Choi, Jiwon Choi, Sung Yeon Cho, Seung-Hun Kim, Heung-Soo Baek, Kee Dong Yoon, Sang Wook Son, Eui Dong Son, Yong-Deog Hong, Jaeyoung Ko, Si-Young Cho, Won-Seok Park
Summary: The inhibition of PDK1 has shown potential as an effective anti-aging intervention, reducing cellular senescence and improving skin appearance through increased collagen fiber.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Materials Science, Biomaterials
Juewon Kim, Shin-Hae Lee, Miook Cho, Jee-Young Lee, Dong-Hwa Choi, Hye-Yeon Lee, Siyoung Cho, Kyung-Jin Min, Yousin Suh
ADVANCED BIOSYSTEMS
(2020)
Meeting Abstract
Biochemistry & Molecular Biology
Juewon Kim, Hyunjung Choi, Hyoung-June Kim
FREE RADICAL BIOLOGY AND MEDICINE
(2019)