期刊
BIOFACTORS
卷 37, 期 3, 页码 219-227出版社
WILEY
DOI: 10.1002/biof.160
关键词
mitochondria; calcium; metabolism; apoptosis; endoplasmic reticulum
资金
- Italian Ministry of Education
- University and Research
- European Union
- Italian Space Agency (ASI)
- NIH [1P01AG025532-01A1]
- Cariparo Foundation (Padua)
- Italian Association for Cancer Research (AIRC)
Mitochondrial Ca2+ homeostasis is an important component of the calcium-mediated cellular response to extracellular stimuli. It controls key organelle functions, such as aerobic metabolism and the induction of apoptotic cell death, and shapes the spatiotemporal pattern of the cytosolic [Ca2+] increase. We here summarize both the main roles of Ca2+ signals within mitochondria and the emerging molecular information that is starting to unravel the composition of the signaling apparatus and reveal potential pharmacological targets in this process of utmost pathophysiological relevance. (C) 2011 International Union of Biochemistry and Molecular Biology, Inc.
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