Article
Multidisciplinary Sciences
Yan Li, Chengyu Zou, Chen Chen, Sixuan Li, Ziyu Zhu, Qiuyue Fan, Rui Pang, Fengshi Li, Zengai Chen, Zhenghong Wang, Weifeng Yu, Junying Yuan, Peiying Li
Summary: This study demonstrates that macrophage migration inhibitory factor (MIF) promotes endothelial cell (EC) death under inflammatory conditions, thus contributing to blood-brain barrier disruption.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Biochemistry & Molecular Biology
Janos Garai, Marcell Kreko, Laszlo Orfi, Peter Balazs Jakus, Zoltan Rumbus, Patrik Keringer, Andras Garami, Eszter Vamos, Dominika Kovacs, Viola Bagone Vantus, Balazs Radnai, Tamas Lorand
Summary: The study shows that certain synthesized tetralones and their derivatives can inhibit MIF's tautomeric functions, regulate macrophage activation, and reduce inflammatory responses.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Yao-Zhong Kong, Qiyan Chen, Hui-Yao Lan
Summary: This review focuses on the regulatory role and molecular mechanisms of macrophage migration inhibitory factor (MIF) in kidney diseases, as well as the therapeutic potential of targeting MIF signaling to treat kidney diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Peripheral Vascular Disease
Ling Zhu, Shasha Chen, Na Liu, Qianwei Cui, Minzhi Ma, Zhongwei Liu, Yujie Xing, Yong Zhang, Junkui Wang
Summary: This study aimed to investigate the potential relationship between plasma macrophage migration inhibitor factor levels and hypertension and hypertensive left ventricular hypertrophy. The results showed that elevated macrophage migration inhibitor factor was associated with the development of hypertension as well as hypertensive left ventricular hypertrophy.
JOURNAL OF HUMAN HYPERTENSION
(2023)
Article
Chemistry, Analytical
Chenwen Shao, Christian Hedberg, Yong Qian
Summary: A novel activity-based probe, TPP2, was reported for direct labeling and imaging of endogenous MIF activity within live cells and in a mouse model of liver cancer. TPP2 allows for the dynamic monitoring of intracellular MIF activity and the identification of liver cancer with high sensitivity and selectivity, providing a promising new imaging approach for elucidating MIF-related biological functions in liver cancer.
ANALYTICAL CHEMISTRY
(2021)
Article
Cell Biology
Lisa Schindler, Leon Zwissler, Christine Krammer, Ulrike Hendgen-Cotta, Tienush Rassaf, Mark B. Hampton, Nina Dickerhof, Jurgen Bernhagen
Summary: The inflammatory cytokines MIF and MIF-2/D-DT inhibit neutrophil apoptosis by activating mononuclear cells to promote neutrophil survival through a synergistic response. The noncognate MIF receptor CXCR2 expressed on both monocytes and neutrophils plays a crucial role in MIF-mediated neutrophil survival.
JOURNAL OF LEUKOCYTE BIOLOGY
(2021)
Article
Medicine, General & Internal
Gabriela Athziri Sanchez-Zuno, Richard Bucala, Jorge Hernandez-Bello, Ilce Valeria Roman-Fernandez, Mariel Garcia-Chagollan, Ferdinando Nicoletti, Monica Guadalupe Matuz-Flores, Samuel Garcia-Arellano, Judith Alejandra Esparza-Michel, Sergio Cerpa-Cruz, Edsaul Emilio Perez-Guerrero, Jose Francisco Munoz-Valle
Summary: Macrophage migration inhibitory factor (MIF) plays a significant role in the pathogenesis of rheumatoid arthritis (RA). This study explored the expression of CD74, CXCR2, CXCR4, and CXCR7, as well as the levels of soluble CD74 (sCD74), in relation to the clinical activity of RA. The results suggest that sCD74 may act as a decoy receptor for MIF and negatively regulate its signaling, while CXCR7 functions as a scavenger-type receptor to prevent endocytosis and degradation of CXCR4 under inflammatory conditions.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Neurosciences
Huifei Hao, Yuxuan Hou, Aicheng Li, Li Niu, Shaolan Li, Bingqiang He, Xingyuan Zhang, Honghua Song, Rixin Cai, Yue Zhou, Chun Yao, Yongjun Wang, Yingjie Wang
Summary: SCI-induced activation of HIF-1a promotes MIF production from astrocytes, which may be beneficial for clinical treatment of neuroinflammation.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Multidisciplinary Sciences
Amanda R. Arnold, Benoit Chassaing, Bradley D. Pearce, Kim L. Huhman
Summary: Dietary emulsifier consumption can cause low-grade inflammation, metabolic deregulation, and potentially anxiety-like phenotypes. This study shows that emulsifier consumption is associated with changes in gene expression in the amygdala and paraventricular nucleus of the hypothalamus, which are important brain areas for stress response. The study also suggests that each emulsifier acts through different molecular mechanisms to produce an anxiety-like phenotype.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Hazel Dunbar, Ian J. Hawthorne, Courteney Tunstead, Michelle E. Armstrong, Seamas C. Donnelly, Karen English
Summary: Macrophage migration inhibitory factor (MIF) expression is affected by a functional promoter polymorphism, with the number of CATT repeats correlating to MIF expression level. In a pre-clinical model of allergic asthma, mice with increasing CATT repeats (CATT(5) and CATT(7)) showed varying degrees of airway inflammation. The potent MIF inhibitor SCD-19 was able to mitigate the pathophysiology observed in CATT(7) mice, indicating the important role of endogenous human MIF expression in airway inflammation severity.
Article
Biochemistry & Molecular Biology
Hazel Dunbar, Ian J. Hawthorne, Courteney Tunstead, Michelle E. Armstrong, Seamas C. Donnelly, Karen English
Summary: The expression of macrophage migration inhibitory factor (MIF) is controlled by a functional promoter polymorphism, where the number of tetranucleotide repeats (CATTn) corresponds to the level of MIF expression. Using a pre-clinical model of allergic asthma, novel humanized MIF mice with increasing CATT repeats (CATT5 and CATT7) were employed to study airway inflammation. The results showed that high expression of human MIF in CATT7 mice led to a severe asthma phenotype, which could be mitigated by the MIF inhibitor SCD-19. This study provides a reproducible model for studying asthma airway remodeling and suggests a potential role of MIF in driving this process.
Article
Biochemistry & Molecular Biology
Caroline Swoboda, Lena Deloch, Claudia von Zimmermann, Tanja Richter-Schmidinger, Bernd Lenz, Johannes Kornhuber, Christiane Muehle
Summary: This study investigated the potential of MIF at genetic, expression, and protein levels as a risk factor and biomarker for diagnosing, monitoring, or predicting MDD. The results suggest a genetic effect of MIF in women but do not provide strong evidence for its utility as a biomarker for MDD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Krishnamoorthi Sumaiya, Dianne Langford, Kalimuthusamy Natarajaseenivasan, Santhanam Shanmughapriya
Summary: Macrophage migration inhibitory factor (MIF) is a key cytokine involved in immune response and physiological processes. It has diverse biological functions, playing a protective role during infectious diseases while also promoting detrimental inflammation and cancer progression. The functional activities of MIF are regulated by genetic and physiological factors. A review on the regulation, functional mechanisms, and MIF-targeting therapies will provide insights into the significance of this protein.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Immunology
Krishnamoorthi Sumaiya, Kalimuthusamy Natarajaseenivasan
Summary: This study found that MIF -173G/C gene promoter polymorphisms are associated with susceptibility and severity of human leptospirosis, with GC and CC genotypes being significantly associated with disease susceptibility and severity.
MICROBIAL PATHOGENESIS
(2022)
Review
Oncology
Romina Mora Barthelmess, Benoit Stijlemans, Jo A. Van Ginderachter
Summary: The aim of this review is to summarize the available information regarding the MIF family in cancer. MIF and DDT are both highly expressed in cancer patients and their functions are related to 9 out of 10 hallmarks of cancer, indicating their potential as therapeutic targets. New diagnostic methods and treatments have decreased the mortality rates of cancer patients, but further improvements are warranted based on the identification of novel tumor-promoting molecules.
Article
Medicine, General & Internal
Aryeh Fischer, Mary E. Strek, Vincent Cottin, Paul F. Dellaripa, Elana J. Bernstein, Kevin K. Brown, Sonye K. Danoff, Oliver Distler, Nik Hirani, Kirk D. Jones, Dinesh Khanna, Joyce S. Lee, David A. Lynch, Toby M. Maher, Ann B. Millar, Ganesh Raghu, Richard M. Silver, Virginia D. Steen, Elizabeth R. Volkmann, Ronan H. Mullan, David N. O'Dwyer, Seamas C. Donnelly
QJM-AN INTERNATIONAL JOURNAL OF MEDICINE
(2019)
Article
Rheumatology
Aryeh Fischer, Mary E. Strek, Vincent Cottin, Paul F. Dellaripa, Elana J. Bernstein, Kevin K. Brown, Sonye K. Danoff, Oliver Distler, Nik Hirani, Kirk D. Jones, Dinesh Khanna, Joyce S. Lee, David A. Lynch, Toby M. Maher, Ann B. Millar, Ganesh Raghu, Richard M. Silver, Virginia D. Steen, Elizabeth R. Volkmann, Ronan H. Mullan, David N. O'Dwyer, Seamas C. Donnelly
ARTHRITIS & RHEUMATOLOGY
(2019)
Editorial Material
Oncology
Shayan Mostafaei, Pegah Vahidi Manesh, Javid Sadri Nahand, Abolfazl Nesaei, Saba Sorayyayi, Fatemeh Abasabadi, Hamed Mirzaei, Ashkan Etemadi, Andrew O' Neill, Seamas C. Donnelly, Mohammad Doroudian, Michelle E. Armstrong, Mohsen Moghoofei
Article
Biotechnology & Applied Microbiology
Mohammad Doroudian, Andrew O'Neill, Ciaran O'Reilly, Aisling Tynan, Leona Mawhinney, Aoife McElroy, Shanice S. Webster, Ronan MacLoughlin, Yuri Volkov, Michelle E Armstrong, George A. O'Toole, Adriele Prina-Mello, Seamas C Donnelly
Review
Respiratory System
Anne Trappe, Seamas C. Donnelly, Paul McNally, Judith A. Coppinger
Summary: Extracellular vesicles (EVs) play crucial roles in chronic lung diseases as mediators of intercellular communication and potential biomarkers and drug carriers. Research indicates that EVs are key players in inflammatory processes, offering new avenues for therapies and pathological investigations in a range of lung diseases.
Article
Critical Care Medicine
Aoife N. McElroy, Rachele Invernizzi, Joanna W. Laskowska, Andrew O'Neill, Mohammad Doroudian, Mohsen Moghoofei, Shayan Mostafaei, Feng Li, Alexander A. Przybylski, David N. O'Dwyer, Andrew G. Bowie, Padraic G. Fallon, Toby M. Maher, Cory M. Hogaboam, Philip L. Molyneaux, Nik Hirani, Michelle E. Armstrong, Seamas C. Donnelly
Summary: The study on the association between TLR3 L412F polymorphism and acute exacerbation-related death in idiopathic pulmonary fibrosis (IPF) reveals that this polymorphism attenuates the immune responses of IPF lung cells to bacteria and dysregulates the lung microbiome in IPF patients.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Review
Immunology
Ralph Panstruga, Seamas C. Donnelly, Juergen Bernhagen
Summary: This article examines the immunomodulatory role of MIF and MDL proteins during Pseudomonas infections in mammals and plants, and identifies differences in their underlying molecular mechanisms.
Article
Biochemistry & Molecular Biology
Hazel Dunbar, Ian J. Hawthorne, Courteney Tunstead, Michelle E. Armstrong, Seamas C. Donnelly, Karen English
Summary: Macrophage migration inhibitory factor (MIF) expression is affected by a functional promoter polymorphism, with the number of CATT repeats correlating to MIF expression level. In a pre-clinical model of allergic asthma, mice with increasing CATT repeats (CATT(5) and CATT(7)) showed varying degrees of airway inflammation. The potent MIF inhibitor SCD-19 was able to mitigate the pathophysiology observed in CATT(7) mice, indicating the important role of endogenous human MIF expression in airway inflammation severity.
Article
Chemistry, Multidisciplinary
Karolina Wojtczak, Eva Zahorska, Ian J. Murphy, Finnja Koppel, Gordon Cooke, Alexander Titz, Joseph P. Byrne
Summary: Interactions between lectins and glycoconjugate-terbium(iii) self-assembly complexes are utilized for sensing by enhancing lanthanide luminescence. This glycan-directed sensing method can detect an unlabelled lectin (LecA) associated with pathogen P. aeruginosa in solution, without bactericidal activity. Further development of these probes holds potential as a diagnostic tool.
CHEMICAL COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Hollie Jenkins, Louise MacLean, Siobhan McClean, Gordon Cooke, Michael Devereux, Orla Howe, Marcos D. Pereira, Nora V. May, Eva A. Enyedy, Bernadette S. Creaven
Summary: This study evaluated the anticancer activity of three copper-based anticancer complexes on breast cancer cells under different oxygen conditions. It was found that one of the complexes exhibited increased cytotoxicity under low oxygen conditions. Additionally, these complexes had the ability to generate reactive oxygen species and act as superoxide dismutase mimics. Solution speciation studies showed that one complex was the dominant species.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2023)
Article
Respiratory System
Suzanne C. Carter, Alessandro N. Franciosi, Kate M. O'Shea, Orla M. O'Carroll, Ashutosh Sharma, Aoife Bell, Brian Keogan, Paul O'Reilly, Suzie Coughlan, Sheonagh M. Law, Robert D. Gray, Katherine B. Hisert, Pradeep K. Singh, Gordon Cooke, Brenda Grogan, Cillian F. De Gascun, Charles G. Gallagher, Trevor T. Nicholson, Bradley S. Quon, Edward F. McKone
Summary: This study reveals that there are different subphenotypes of CF pulmonary exacerbations, characterized by differences in biomarker profiles, clinical presentation, and outcomes. Viral infection status and C-reactive protein levels can be used to classify these subphenotypes, providing potential guidance for predicting prognosis.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2022)
Review
Cell Biology
Mark J. Kelly, Caitriona Breathnach, Kevin J. Tracey, Seamas C. Donnelly
Summary: The cholinergic anti-inflammatory pathway is a neural circuit that allows the central nervous system to modulate peripheral immune responses. It has been shown to play a role in various inflammatory diseases and has therapeutic potential. Pre-clinical studies have demonstrated the efficacy of this pathway, and promising clinical trials have translated these findings into potential treatments.
CELL REPORTS MEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Ciaran O'Reilly, Salvador Blasco, Bina Parekh, Helen Collins, Gordon Cooke, Thorfinnur Gunnlaugsson, Joseph P. Byrne
Summary: Carbohydrate-decorated clusters centred on a Ru(ii) ion were synthesized and tested for their activity against Pseudomonas aeruginosa biofilm formation. Among them, glycocluster 8Gal with a flexible spacer showed significant inhibition of P. aeruginosa bacterial biofilm formation.
Meeting Abstract
Medicine, General & Internal
S. C. Carter, L. Kirwan, K. B. Hisert, G. Cooke, P. Singh, C. G. Gallagher, E. F. McKone
IRISH JOURNAL OF MEDICAL SCIENCE
(2019)
Meeting Abstract
Cardiac & Cardiovascular Systems
A. Russell-Hallinan, N. Glezeva, I. McDonald, G. Cooke, M. Ledwidge, K. McDonald, R. Burden, C. Watson
