Histone Lysine and Genomic Targets of Histone Acetyltransferases in Mammals

Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth

(2018) Jonathan B. Baell et al.   NATURE

CBP Regulates Recruitment and Release of Promoter-Proximal RNA Polymerase II

(2017) Ann Boija et al.   MOLECULAR CELL

The evolutionary significance of polyploidy

(2017) Yves Van de Peer et al.   NATURE REVIEWS GENETICS

Recognition of Histone H3K14 Acylation by MORF

(2017) Brianna J. Klein et al.   STRUCTURE

Phosphorylated HBO1 at UV irradiated sites is essential for nucleotide excision repair

(2017) Hiroyuki Niida et al.   Nature Communications

KAT-Independent Gene Regulation by Tip60 Promotes ESC Self-Renewal but Not Pluripotency

(2017) Diwash Acharya et al.   Cell Reports

Widespread Mitotic Bookmarking by Histone Marks and Transcription Factors in Pluripotent Stem Cells

(2017) Yiyuan Liu et al.   Cell Reports

MOZ (KAT6A) is essential for the maintenance of classically defined adult hematopoietic stem cells

(2016) B. N. Sheikh et al.   BLOOD

Histone acetyltransferase activity of MOF is required for adult but not early fetal hematopoiesis in mice

(2016) Daria G. Valerio et al.   BLOOD

Small RNAs Recruit Chromatin-Modifying Enzymes MMSET and Tip60 to Reconfigure Damaged DNA upon Double-Strand Break and Facilitate Repair

(2016) Qinhong Wang et al.   CANCER RESEARCH

The TIP60 Complex Regulates Bivalent Chromatin Recognition by 53BP1 through Direct H4K20me Binding and H2AK15 Acetylation

(2016) Karine Jacquet et al.   MOLECULAR CELL

Selective recognition of histone crotonylation by double PHD fingers of MOZ and DPF2

(2016) Xiaozhe Xiong et al.   Nature Chemical Biology

NOTCH1 Inhibits Activation of ATM by Impairing the Formation of an ATM-FOXO3a-KAT5/Tip60 Complex

(2016) Marek Adamowicz et al.   Cell Reports

MOZ regulates B-cell progenitors and, consequently, Moz haploinsufficiency dramatically retards MYC-induced lymphoma development

(2015) B. N. Sheikh et al.   BLOOD

KAT6B Is a Tumor Suppressor Histone H3 Lysine 23 Acetyltransferase Undergoing Genomic Loss in Small Cell Lung Cancer

(2015) Laia Simó-Riudalbas et al.   CANCER RESEARCH

BRPF3-HBO1 regulates replication origin activation and histone H3K14 acetylation

(2015) Y. Feng et al.   EMBO JOURNAL

Myc and SAGA rewire an alternative splicing network during early somatic cell reprogramming

(2015) Calley L. Hirsch et al.   GENES & DEVELOPMENT

UV Damage-Induced Phosphorylation of HBO1 Triggers CRL4DDB2-Mediated Degradation To Regulate Cell Proliferation

(2015) Ryoichi Matsunuma et al.   MOLECULAR AND CELLULAR BIOLOGY

An Interactive Database for the Assessment of Histone Antibody Specificity

(2015) Scott B. Rothbart et al.   MOLECULAR CELL

Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from promoters and enhancers

(2015) Isaac B Hilton et al.   NATURE BIOTECHNOLOGY

MOZ (MYST3, KAT6A) inhibits senescence via the INK4A-ARF pathway

(2015) B N Sheikh et al.   ONCOGENE

MOF maintains transcriptional programs regulating cellular stress response

(2015) B N Sheikh et al.   ONCOGENE

Regulation of RNA polymerase II activation by histone acetylation in single living cells

(2014) Timothy J. Stasevich et al.   NATURE

The growing landscape of lysine acetylation links metabolism and cell signalling

(2014) Chunaram Choudhary et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Histone H3 lysine 4 trimethylation regulates cotranscriptional H2A variant exchange by Tip60 complexes to maximize gene expression

(2014) Thomas Kusch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamic Interactions between TIP60 and p300 Regulate FOXP3 Function through a Structural Switch Defined by a Single Lysine on TIP60

(2014) Yan Xiao et al.   Cell Reports

MOF-associated complexes ensure stem cell identity and Xist repression

(2014) Tomasz Chelmicki et al.   eLife

SET1 and p300 Act Synergistically, through Coupled Histone Modifications, in Transcriptional Activation by p53

(2013) Zhanyun Tang et al.   CELL

Exchange of associated factors directs a switch in HBO1 acetyltransferase histone tail specificity

(2013) M.-E. Lalonde et al.   GENES & DEVELOPMENT

SCFFbxw15Mediates Histone Acetyltransferase Binding to Origin Recognition Complex (HBO1) Ubiquitin-Proteasomal Degradation to Regulate Cell Proliferation

(2013) Chunbin Zou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

KAT5 tyrosine phosphorylation couples chromatin sensing to ATM signalling

(2013) Abderrahmane Kaidi et al.   NATURE

Structure of the p300 catalytic core and implications for chromatin targeting and HAT regulation

(2013) Manuela Delvecchio et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Regulation of nucleosome dynamics by histone modifications

(2013) Gabriel E Zentner et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The double PHD finger domain of MOZ/MYST3 induces  -helical structure of the histone H3 tail to facilitate acetylation and methylation sampling and modification

(2013) I. Dreveny et al.   NUCLEIC ACIDS RESEARCH

MOZ-Mediated Repression ofp16INK4aIs Critical for the Self-Renewal of Neural and Hematopoietic Stem Cells

(2013) Flor M. Perez-Campo et al.   STEM CELLS

H3K9 and H3K14 acetylation co-occur at many gene regulatory elements, while H3K14ac marks a subset of inactive inducible promoters in mouse embryonic stem cells

(2012) Krishanpal Karmodiya et al.   BMC GENOMICS

The histone acetyltransferases CBP and Chameau integrate developmental and DNA replication programs in Drosophila ovarian follicle cells

(2012) K. H. McConnell et al.   DEVELOPMENT

MOZ Regulates the Tbx1 Locus, and Moz Mutation Partially Phenocopies DiGeorge Syndrome

(2012) Anne K. Voss et al.   DEVELOPMENTAL CELL

Combinatorial readout of unmodified H3R2 and acetylated H3K14 by the tandem PHD finger of MOZ reveals a regulatory mechanism for HOXA9 transcription

(2012) Y. Qiu et al.   GENES & DEVELOPMENT

Structures of KIX domain of CBP in complex with two FOXO3a transactivation domains reveal promiscuity and plasticity in coactivator recruitment

(2012) F. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Hbo1-Brd1/Brpf2 complex is responsible for global acetylation of H3K14 and required for fetal liver erythropoiesis

(2011) Y. Mishima et al.   BLOOD

Readers of histone modifications

(2011) Miyong Yun et al.   CELL RESEARCH

Sgf29 binds histone H3K4me2/3 and is required for SAGA complex recruitment and histone H3 acetylation

(2011) Chuanbing Bian et al.   EMBO JOURNAL

Methylation specifies distinct estrogen-induced binding site repertoires of CBP to chromatin

(2011) D. G. Ceschin et al.   GENES & DEVELOPMENT

Partial loss of Tip60 slows mid-stage neurodegeneration in a spinocerebellar ataxia type 1 (SCA1) mouse model

(2011) Kristin M. Gehrking et al.   HUMAN MOLECULAR GENETICS

Conserved Molecular Interactions within the HBO1 Acetyltransferase Complexes Regulate Cell Proliferation

(2011) N. Avvakumov et al.   MOLECULAR AND CELLULAR BIOLOGY

Recognition of enhancer element–specific histone methylation by TIP60 in transcriptional activation

(2011) Kwang Won Jeong et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

SAGA function in tissue-specific gene expression

(2011) Vikki M. Weake et al.   TRENDS IN CELL BIOLOGY

Distinct roles of GCN5/PCAF-mediated H3K9ac and CBP/p300-mediated H3K18/27ac in nuclear receptor transactivation

(2010) Qihuang Jin et al.   EMBO JOURNAL

HBO1 Is Required for H3K14 Acetylation and Normal Transcriptional Activity during Embryonic Development

(2010) A. J. Kueh et al.   MOLECULAR AND CELLULAR BIOLOGY

HBO1 Histone Acetylase Activity Is Essential for DNA Replication Licensing and Inhibited by Geminin

(2010) Benoit Miotto et al.   MOLECULAR CELL

The Nonspecific Lethal Complex Is a Transcriptional Regulator in Drosophila

(2010) Sunil Jayaramaiah Raja et al.   MOLECULAR CELL

An assessment of histone-modification antibody quality

(2010) Thea A Egelhofer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The histone acetyl transferase activity of monocytic leukemia zinc finger is critical for the proliferation of hematopoietic precursors

(2009) F. M. Perez-Campo et al.   BLOOD

Genome-wide Mapping of HATs and HDACs Reveals Distinct Functions in Active and Inactive Genes

(2009) Zhibin Wang et al.   CELL

Moz and Retinoic Acid Coordinately Regulate H3K9 Acetylation, Hox Gene Expression, and Segment Identity

(2009) Anne K. Voss et al.   DEVELOPMENTAL CELL

Homozygous disruption of thetip60gene causes early embryonic lethality

(2009) Yaofei Hu et al.   DEVELOPMENTAL DYNAMICS

HBO1 HAT Complexes Target Chromatin throughout Gene Coding Regions via Multiple PHD Finger Interactions with Histone H3 Tail

(2009) Nehmé Saksouk et al.   MOLECULAR CELL

CBP/p300-mediated acetylation of histone H3 on lysine 56

(2009) Chandrima Das et al.   NATURE

ChIP-seq accurately predicts tissue-specific activity of enhancers

(2009) Axel Visel et al.   NATURE

Histone H3 methylation links DNA damage detection to activation of the tumour suppressor Tip60

(2009) Yingli Sun et al.   NATURE CELL BIOLOGY

Dynamic bookmarking of primary response genes by p300 and RNA polymerase II complexes

(2009) J. S. Byun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Different Functional Modes of p300 in Activation of RNA Polymerase III Transcription from Chromatin Templates

(2008) C. Mertens et al.   MOLECULAR AND CELLULAR BIOLOGY

Mof (MYST1 or KAT8) Is Essential for Progression of Embryonic Development Past the Blastocyst Stage and Required for Normal Chromatin Architecture

(2008) T. Thomas et al.   MOLECULAR AND CELLULAR BIOLOGY

The many roles of histone deacetylases in development and physiology: implications for disease and therapy

(2008) Michael Haberland et al.   NATURE REVIEWS GENETICS

Transcriptional regulation of chondrogenesis by coactivator Tip60 via chromatin association with Sox9 and Sox5

(2008) Takako Hattori et al.   NUCLEIC ACIDS RESEARCH