期刊
BIOESSAYS
卷 36, 期 6, 页码 585-590出版社
WILEY
DOI: 10.1002/bies.201400003
关键词
archaea; bacteria; RadA; recombination; replication initiation; replication origin
资金
- Swedish Research Council [621-2010-5551]
- Agence Nationale de la Recherche [ANR 11-BSV-006-01]
Replication of the main chromosome in the halophilic archaeon Haloferax volcanii was recently reported to continue despite deletion of all active replication origins. Equally surprising, the deletion strain grew faster than the parent strain. It was proposed that origin-less H. volcanii duplicate their chromosomes via recombination-dependent replication. Here, we recall our present knowledge of this mode of chromosome replication in different organisms. We consider the likelihood that it accounts for the viability of H. volcanii deleted for its main specific replication origins, as well as possible alternative interpretations of the results. The selective advantages of having defined chromosome replication origins are discussed from a functional and evolutionary perspective.
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