Review
Oncology
Soudeh Ghafouri-Fard, Tayyebeh Khoshbakht, Bashdar Mahmud Hussen, Mohammad Taheri, Majid Samsami
Summary: The Sonic Hedgehog (Shh) signaling pathway plays a crucial role in tumor formation, resistance to conventional therapies, tissue regeneration, and neurodegenerative disorders. Numerous non-coding RNAs (ncRNAs) and miRNAs have been identified to interact with the Shh pathway in both malignant and non-malignant conditions. This review summarizes the interactions between ncRNAs and Shh in various contexts.
CANCER CELL INTERNATIONAL
(2022)
Review
Cell Biology
Zhuo Xie, Mudan Zhang, Gaoshi Zhou, Lihui Lin, Jing Han, Ying Wang, Li Li, Yao He, Zhirong Zeng, Minhu Chen, Shenghong Zhang
Summary: The Hedgehog (Hh) signalling pathway is crucial in embryonic development and maintaining adult tissue homeostasis, and has been implicated in the pathogenesis of inflammatory bowel disease (IBD). Targeting the Hh signalling pathway may pave the way for successful IBD treatment. Understanding the complex role of Hh signalling in IBD pathogenesis could lead to the development of new effective therapies for IBD.
CELL DEATH DISCOVERY
(2021)
Review
Pharmacology & Pharmacy
Florian Herms, Nicole Basset-Seguin
Summary: Basal cell carcinoma (BCC) is the most common skin malignancy, with most cases curable through local treatments but requiring specific therapies for advanced forms. Significant progress has been made in targeting the sonic hedgehog pathway and developing new therapies. While surgery remains the gold standard, treatment for recurrent and advanced tumors is evolving, and there is a need for new targeted therapies to overcome resistance.
EXPERT OPINION ON EMERGING DRUGS
(2021)
Review
Pharmacology & Pharmacy
Kinjal Patel, Nicola J. Smith
Summary: Primary cilia are important for sensing environmental changes in mammalian cells through the Sonic Hedgehog pathway. GPR161 is a significant player in primary cilia and its unique features may affect receptor function and cAMP compartmentalisation. The recent potential pairing of GPR161 and spexin-1 requires further investigation before GPR161 is considered 'deorphanised'. The constitutive activity and unconventional regulation of GPR161 suggest that it may not require an endogenous ligand.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Geriatrics & Gerontology
Oluwarantimi Adetunji, David Bishai, Cuong Viet Pham, Janiece Taylor, Ngan Tran Thi, Zainab Khan, Abdulgafoor M. Bachani
Summary: The study aims to provide a culturally relevant and validated instrument to assess the geriatric knowledge of healthcare providers in Vietnam. By translating and validating the instrument, the Vietnamese Knowledge about Older Patients Quiz (VKOP-Q) was developed. The pilot study indicated that healthcare providers had low scores in areas such as geriatric physiopathology, communication techniques with sensory impaired older adults, and differentiating age-related changes from abnormal changes or symptoms.
Article
Education & Educational Research
Akshaya Srikanth Bhagavathula, Deepak Kumar Bandari, Bhagya Sri Areman, Daniela Fialova
Summary: This study compared the knowledge of aging and rational geriatric pharmacotherapy among BPharm and PharmD students in Telangana state, India. The findings showed that both groups of students had inadequate knowledge in these areas, which may be attributed to a lack of geriatric content in the pharmacy curriculum and insufficient training in this field.
GERONTOLOGY & GERIATRICS EDUCATION
(2022)
Review
Biochemistry & Molecular Biology
Tilman Borggrefe, Matthias Lauth, An Zwijsen, Danny Huylebroeck, Franz Oswald, Benedetto Daniele Giaimo
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2016)
Article
Oncology
Rajeev Singh, Pavan Kumar Dhanyamraju, Matthias Lauth
Article
Biochemistry & Molecular Biology
Miroslava Didiasova, Rajeev Singh, Jochen Wilhelm, Grazyna Kwapiszewska, Lukasz Wujak, Dariusz Zakrzewicz, Liliana Schaefer, Philipp Markart, Werner Seeger, Matthias Lauth, Malgorzata Wygrecka
Article
Biochemistry & Molecular Biology
Volker Fendrich, Frederike Jendryschek, Saskia Beeck, Max Albers, Matthias Lauth, Farzad Esni, Kristin Heeger, Janina Dengler, Emily P. Slater, Julia P. N. Holler, Aninja Baier, Detlef K. Bartsch, Jens Waldmann
Article
Gastroenterology & Hepatology
Albrecht Neesse, Christian Alexander Bauer, Daniel Ohlund, Matthias Lauth, Malte Buchholz, Patrick Michl, David A. Tuveson, Thomas M. Gress
Article
Biochemistry & Molecular Biology
Rajeev Singh, Philipp Simon Holz, Katrin Roth, Anna Hupfer, Wolfgang Meissner, Rolf Mueller, Malte Buchholz, Thomas M. Gress, Hans-Peter Elsaesser, Ralf Jacob, Matthias Lauth
CELLULAR AND MOLECULAR LIFE SCIENCES
(2019)
Article
Multidisciplinary Sciences
Maik Luu, Sabine Pautz, Vanessa Kohl, Rajeev Singh, Rossana Romero, Sebastien Lucas, Joerg Hofmann, Hartmann Raifer, Niyati Vachharajani, Lucia Campos Carrascosa, Boris Lamp, Andrea Nist, Thorsten Stiewe, Yoav Shaul, Till Adhikary, Mario M. Zaiss, Matthias Lauth, Ulrich Steinhoff, Alexander Visekruna
NATURE COMMUNICATIONS
(2019)
Article
Chemistry, Medicinal
Ilya Galperin, Lukas Dempwolff, Wibke E. Diederich, Matthias Lauth
JOURNAL OF MEDICINAL CHEMISTRY
(2019)
Article
Biochemistry & Molecular Biology
Anna Hupfer, Anna Brichkina, Till Adhikary, Matthias Lauth
Summary: Medulloblastoma is the most common malignant brain tumor in children, with one subgroup driven by uncontrolled Hedgehog signaling. While clinically approved compounds exclusively target the transmembrane component Smoothened, drug resistance against SMO inhibitors is encountered frequently, highlighting the importance of identifying novel Hh pathway components.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Oncology
Anke Koeniger, Anna Brichkina, Iris Nee, Lukas Dempwolff, Anna Hupfer, Ilya Galperin, Florian Finkernagel, Andrea Nist, Thorsten Stiewe, Till Adhikary, Wibke Diederich, Matthias Lauth
Summary: Elevated GLI1 expression levels are associated with improved survival in NB patients and GLI1 overexpression exerts tumor-suppressive traits in cultured NB cells. However, NB cells are protected from increased GLI1 levels as they have lost their primary cilia and ability to transduce Hedgehog signals. An isoxazole molecule (ISX) has been identified to activate GLI1 independently of primary cilia, providing a potential therapeutic strategy for NB treatment.
Article
Biochemistry & Molecular Biology
Ekaterina Ivanova, Shrey Dharamvir Sharma, Anna Brichkina, Petra Pfefferle, Ursula Keber, Axel Pagenstecher, Matthias Lauth
Summary: In neuroblastoma, the overexpression of DYRK3 kinase is associated with decreased survival rate in patients. DYRK3 functions as a negative regulator of HIF-driven transcriptional responses in NB cells and negatively impacts cell differentiation, suggesting an oncogenic role in the etiology of NB.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Maik Luu, Zeno Riester, Adrian Baldrich, Nicole Reichardt, Samantha Yuille, Alessandro Busetti, Matthias Klein, Anne Wempe, Hanna Leister, Hartmann Raifer, Felix Picard, Khalid Muhammad, Kim Ohl, Rossana Romero, Florence Fischer, Christian A. Bauer, Magdalena Huber, Thomas M. Gress, Matthias Lauth, Sophia Danhof, Tobias Bopp, Thomas Nerreter, Imke E. Mulder, Ulrich Steinhoff, Michael Hudecek, Alexander Visekruna
Summary: Short-chain fatty acids pentanoate and butyrate can enhance the anti-tumor activity of immune cells through metabolic and epigenetic reprogramming, making them potential therapeutic agents in cancer immunotherapy.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Anna Hupfer, Anna Brichkina, Anke Koeniger, Corinna Keber, Carsten Denkert, Petra Pfefferle, Frederik Helmprobst, Axel Pagenstecher, Alexander Visekruna, Matthias Lauth
Summary: Increased tissue stiffness can enhance disease progression and support cancer cell growth through promoting stiffness-induced autophagy in stromal cells, mediated by Integrin alpha V signaling pathway. This reveals a potential target for disrupting tumor-stroma crosstalk and manipulating the tumor microenvironment.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Editorial Material
Cell Biology
Steven Y. Cheng, Matthias Lauth, Aimin Liu
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Developmental Biology
Rajeev Singh, Matthias Lauth
JOURNAL OF DEVELOPMENTAL BIOLOGY
(2017)
