期刊
BIOESSAYS
卷 36, 期 6, 页码 579-584出版社
WILEY-BLACKWELL
DOI: 10.1002/bies.201400005
关键词
H3.3; histone variant; turnover
资金
- Chinese Ministry of Science and Technology [2011CB812700, 2011CB965300]
- Howard Hughes Medical Institute International Early Career Scientist Program
Histone H3.3 turnover displays distinct dynamics at various genomic elements such as promoters, enhancers, gene bodies, and heterochromatic regions, suggesting that it is differentially regulated according to chromatin context. Incorporation of variant histones into chromatin provides a mechanism to modulate chromatin states in addition to histone modifications. The replication-independent deposition and replacement of histone variant H3.3, i.e. H3.3 turnover, is mainly associated with transcriptional activity. H3.3 or H3.3-like histone turnover has been studied in various organisms from yeast to mammals. Here, we review the recent progress on this topic. The diversified turnover profiles of H3.3, and their corresponding underlying mechanisms, may reflect distinct requirements for chromatin accessibility in different biological events.
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