Article
Biochemistry & Molecular Biology
Raju V. S. Rajala
Summary: The field of phosphoinositide signaling has expanded significantly in recent years, with phosphoinositides playing a crucial role in regulating various cellular functions. Recent studies have focused on PIP lipid signaling in the retina, highlighting the importance of investigating the function and mechanism of PIP-modifying enzymes/phosphatases in future research.
JOURNAL OF LIPID RESEARCH
(2021)
Article
Cell Biology
Luis Arpa, Carlos Batlle, Peijin Jiang, Carme Caelles, Jorge Lloberas, Antonio Celada
Summary: IL-4 is a key activator of macrophage alternative activation and induces an anti-inflammatory phenotype. The IL-4 signaling pathway involves STAT-6 and MAPK family members. We found that JNK-1 activation regulates the expression of genes involved in alternative activation in response to IL-4.
Review
Plant Sciences
Myrthe Praat, Ive De Smet, Martijn van Zanten
Summary: Plants need to adapt to changing temperature conditions in their environment to survive and thrive. Various protein kinases are involved in plant responses to cold acclimation and heat stress, but their roles in mild temperature changes remain poorly understood. Understanding plant temperature responses is crucial for developing thermotolerant crops.
JOURNAL OF EXPERIMENTAL BOTANY
(2021)
Article
Multidisciplinary Sciences
Xiaoyu Guo, Xue Ding, Juan Dong
Summary: In this study, the authors found that BSL proteins in Arabidopsis have different functions in the cell cortex and nucleus, regulating stomatal formation through the activation or deactivation of different signaling pathways.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Ammaji Rajala, Rahul Rajala, Kenneth Teel, Raju V. S. Rajala
Summary: This study demonstrates, for the first time, the expression of PI kinases, PI phosphatases, and nuclear PIPs in rod photoreceptor cells, and provides information on the distribution of these enzymes in the retina and photoreceptor cells.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2022)
Review
Food Science & Technology
Shoukui He, Karen Fong, Siyun Wang, Xianming Shi
Summary: Foodborne pathogens can develop adaptive responses to sublethal doses of ethanol, increasing their stress tolerance and potentially undermining current intervention strategies for food safety. Further research is needed to effectively mitigate ethanol adaptation in these pathogens.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2021)
Article
Biochemistry & Molecular Biology
Jaakko L. O. Pohjoismaeki, Steffi Goffart
Summary: This article discusses the physiological consequences of radiation exposure and its relationship with oxidative stress signaling. Radiation exposure may trigger multiple signaling pathways that result in metabolic changes. Understanding these impacts can help in devising strategies to mitigate the long-term effects of radiation exposure, such as researching the use of radiation exposure biomarkers and radiation hormesis.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Review
Biochemistry & Molecular Biology
Alessandra V. S. Faria, Sheila S. Andrade, Maikel P. Peppelenbosch, Carmen Ferreira-Halder, Gwenny M. Fuhler
Summary: Platelets are specialized cell fragments that play crucial roles in hemostasis, angiogenesis, inflammation, and immunity. Their functions are mediated through various receptors and regulated by protein phosphorylation. Despite their importance, the molecular pathways underlying platelet activation are still being investigated, with a growing emphasis on the role of phosphatases in these processes.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2021)
Review
Cell Biology
Haiyang Zhou, Lei Wang, Shuai Liu, Wei Wang
Summary: This review discusses the role of each isoform of PI3K in the immune-inflammatory response of abdominal aortic aneurysm (AAA), providing insights into the inflammatory and immune response mechanisms of this disease.
Article
Pharmacology & Pharmacy
Ava Safaroghli-Azar, Mohammad-Javad Sanaei, Atieh Pourbagheri-Sigaroodi, Davood Bashash
Summary: Lipid signaling refers to the biological process in which a lipid messenger binds to a protein target, converting its effects to specific cellular responses. The family of phosphoinositide 3-kinase (PI3K) plays a crucial role in this pathway, affecting various aspects of cellular biology such as cell survival, proliferation, migration, endocytosis, intracellular trafficking, metabolism, and autophagy. Different classes of PI3Ks have been identified in yeast and mammals, with class I PI3Ks being extensively studied in cancer biology. Abnormal activation of class I PI3Ks has been implicated in human tumors, particularly through activating mutations in the PIK3CA gene. Class II and III PI3Ks are involved in regulating vesicle trafficking and autophagy processes. This review aims to discuss the latest research findings on PI3Ks-mediated cell biological processes and explore the mechanisms by which different types of phosphoinositides derived from PI3Ks act.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Irshad Sharafutdinov, Jakob Knorr, Klemens Rottner, Steffen Backert, Nicole Tegtmeyer
Summary: Pathogenic bacteria pose a serious threat to human and animal health, and the dynamics of actin cytoskeleton play a crucial role in host-pathogen interactions. Cortactin, a major cellular factor, is involved in the regulation of these interactions, and various microbes have been reported to exploit cortactin signaling during infection.
MOLECULAR MICROBIOLOGY
(2022)
Article
Multidisciplinary Sciences
Alessandro Poli, Shidqiyyah Abdul-Hamid, Antonio Enrico Zaurito, Francesca Campagnoli, Valeria Bevilacqua, Bhavwanti Sheth, Roberta Fiume, Massimiliano Pagani, Sergio Abrignani, Nullin Divecha
Summary: Regulatory T cells (Tregs) are crucial in maintaining peripheral tolerance and preventing autoimmunity, but their recruitment in tumor microenvironments can suppress immune surveillance. Pharmacological inhibition of PIP4K can reprogram human Treg identity without significantly impacting T conventional cell signaling, potentially improving therapeutic outcomes.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Plant Sciences
Lizhen Song, Yanning Wang, Zhiai Guo, Sin M. Lam, Guanghou Shui, Youfa Cheng
Summary: Phosphoinositides play vital roles in plant growth and development, with SAC6 to SAC8 identified as crucial phosphatases in Arabidopsis involved in auxin signaling and embryo development. These genes exhibit specific and overlapping expression patterns in seedlings and embryos, and mutations can lead to abnormal seed and cotyledon development. Mutants of SAC6 to SAC8 show delayed or lethal embryo development, with disruptions in auxin maxima and increased levels of PtdIns4P and PtdIns(4,5)P2. Dysfunction in these genes also affects protein trafficking from trans-Golgi network/early endosome to plasma membrane, impacting auxin-mediated development in Arabidopsis.
Article
Cell Biology
Michal Skruzny
Summary: This review summarizes the important protein players, molecular functions, applied forces, and open questions and perspectives of the robust, actin-powered membrane-remodeling protein machine in yeast endocytosis.
EUROPEAN JOURNAL OF CELL BIOLOGY
(2022)
Review
Immunology
Tatiana M. Clemente, Rajendra K. Angara, Stacey D. Gilk
Summary: Obligate intracellular pathogens can either reside freely in the host cell cytoplasm or be confined in a membrane-bound vacuole. The pathogens in membrane-bound vacuoles are protected from the innate immune system and antimicrobial drugs, but they face challenges such as obtaining membrane components, maintaining a suitable microenvironment, acquiring essential nutrients from the host cell, and manipulating the host cell through a specialized secretion system.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Patricia Leme Goto, Mathieu Cinato, Fadi Merachli, Bohdana Vons, Tony Jimenez, Dimitri Marsal, Nika Todua, Halyna Loi, Yohan Santin, Stephanie Cassel, Muriel Blanzat, Helene Tronchere, Christophe Dejugnat, Oksana Kunduzova, Frederic Boal
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2020)
Article
Nanoscience & Nanotechnology
T. Sansen, D. Sanchez-Fuentes, R. Rathar, A. Colom-Diego, F. El Alaoui, J. Viaud, M. Macchione, S. de Rossi, S. Matile, R. Gaudin, V. Backer, A. Carretero-Genevrier, L. Picas
ACS APPLIED MATERIALS & INTERFACES
(2020)
Article
Biochemistry & Molecular Biology
Typhaine Anquetil, Romain Solinhac, Aude Jaffre, Gaetan Chicanne, Julien Viaud, Jean Darcourt, Cyrille Orset, Eva Geuss, Christoph Kleinschnitz, Bart Vanhaesebroeck, Denis Vivien, Karim Hnia, Vincent Larrue, Bernard Payrastre, Marie-Pierre Gratacap
Summary: Protecting endothelial cells is critical in preventing the impact of vascular leakage and edema on pathological conditions. PI3KC2 beta could be a potential new therapeutic target for treating aggravating lesions following ischemic stroke.
Article
Biochemistry & Molecular Biology
Ilenia Martinelli, Andrei Timotin, Paula Moreno-Corchado, Dimitri Marsal, Solomiia Kramar, Halina Loy, Carine Joffre, Frederic Boal, Helene Tronchere, Oksana Kunduzova
Summary: Galanin regulates cardiac autophagy and inhibits apoptotic cell death through the FoxO1 pathway, promoting cell survival and protecting against hypertrophic reprogramming in the heart.
Article
Biochemistry & Molecular Biology
Halyna Loi, Solomiia Kramar, Charlotte Laborde, Dimitri Marsal, Nathalie Pizzinat, Daniel Cussac, Jerome Roncalli, Frederic Boal, Helene Tronchere, Oleksandra Oleshchuk, Mykhaylo Korda, Oksana Kunduzova
Summary: This study investigates the role of the antihyperglycemic agent metformin in postinfarction fibrotic and inflammatory remodeling in mice, demonstrating that metformin treatment reduces fibrotic remodeling and CD68-positive cell population after myocardial infarction. Expression of COL3A1, alpha SMA, and CD68 were also decreased with metformin treatment, highlighting the potential of metformin as a therapeutic option for adverse cardiac remodeling after MI.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biology
Fatima El Alaoui, Ignacio Casuso, David Sanchez-Fuentes, Charlotte Arpin-Andre, Raissa Rathar, Volker Baecker, Anna Castro, Thierry Lorca, Julien Viaud, Stephane Vassilopoulos, Adrian Carretero-Genevrier, Laura Picas
Summary: Clathrin-mediated endocytosis (CME) is a central trafficking pathway in eukaryotic cells regulated by phosphoinositides. The study reveals the molecular dynamics of FCHo2 self-assembly on membranes, showing that it forms ring-like-shaped protein patches and enhances PI(4,5)P-2 clustering, leading to increased clathrin assembly.
Article
Medicine, Research & Experimental
Antoine Deney, Vanessa Nader, Anthony Matta, Romain Itier, Pauline Fournier, Olivier Lairez, Nathalie Pizzinat, Didier Carrie, Frederic Boal, Michel Galinier, Oksana Kunduzova, Rania Azar, Jerome Roncalli
Summary: This study found that more than half of patients with heart failure had coronary artery disease, and older age and male sex were common risk factors for both HFpEF and HFrEF.
MEDICAL SCIENCE MONITOR
(2022)
Article
Multidisciplinary Sciences
Antoine Oprescu, Deborah Michel, Adrien Antkowiak, Elodie Vega, Julien Viaud, Sara A. Courtneidge, Anita Eckly, Henri de la Salle, Gaetan Chicanne, Catherine Leon, Bernard Payrastre, Frederique Gaits-Iacovoni
Summary: This study reveals that bone marrow megakaryocytes undergo structural and compositional changes in their podosomes during maturation, which correlates with the shift in their functional roles.
SCIENTIFIC REPORTS
(2022)
Article
Pharmacology & Pharmacy
Frederic Boal, Mathieu Cinato, Andrei Timotin, Heike Muenzberg, Emily Qualls-Creekmore, Solomiia Kramar, Halyna Loi, Jerome Roncalli, Sokhna Keita, Helene Tronchere, Oksana Kunduzova
Summary: The regulatory peptide galanin plays an important role in the heart, with GalR2 identified as the predominant receptor subtype in adult mouse hearts. Suppression of GalR2 gene promotes cardiac hypertrophy, fibrosis, and mitochondrial oxidative stress. In vitro experiments have shown that silencing GalR2 affects the effects of galanin on cells.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Clinical Neurology
Jonathan R. Volpatti, Mehdi M. Ghahramani-Seno, Melanie Mansat, Nesrin Sabha, Ege Sarikaya, Sarah J. Goodman, Eric Chater-Diehl, Alper Celik, Emanuela Pannia, Carine Froment, Lucie Combes-Soia, Nika Maani, Kyoko E. Yuki, Gaetan Chicanne, Liis Uuskula-Reimand, Simon Monis, Sana Akhtar Alvi, Casie A. Genetti, Bernard Payrastre, Alan H. Beggs, Carsten G. Bonnemann, Francesco Muntoni, Michael D. Wilson, Rosanna Weksberg, Julien Viaud, James J. Dowling
Summary: In this study, we identified valproic acid as a potential therapy for XLMTM through drug screening in zebrafish and mouse models. We found that valproic acid suppresses the disease phenotype by inhibiting HDAC and normalizing DNA methylation. Additionally, we discovered a unique DNA methylation signature in XLMTM patients, suggesting that epigenetic alterations could be targeted for therapeutic intervention.
ACTA NEUROPATHOLOGICA
(2022)
Article
Hematology
Manuella Caux, Rana Mansour, Jean-Marie Xuereb, Gaetan Chicanne, Julien Viaud, Alicia Vauclard, Frederic Boal, Bernard Payrastre, Helene Tronchere, Sonia Severin
Summary: This study demonstrates that PIKfyve and its lipid products PtdIns5P and PtdIns(3,5)P-2 play crucial roles in regulating granule integrity in both megakaryocytes and platelets. Inhibition of PIKfyve leads to impaired granule integrity, affecting platelet aggregation and thrombus formation.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Medicine, General & Internal
Jana Block, Christina Rashkova, Irinka Castanon, Samaneh Zoghi, Jessica Platon, Rico C. Ardy, Mitsuhiro Fujiwara, Beatriz Chaves, Rouven Schoppmeyer, Caspar I. van der Made, Raul Jimenez Heredia, Frederike L. Harms, Samin Alavi, Laia Alsina, Paula Sanchez Moreno, Rainiero Avila Polo, Rocio Cabrera-Perez, Sevgi Kostel Bal, Laurene Pfajfer, Bernhard Ransmayr, Anna-Katharina Mautner, Ryohei Kondo, Anna Tinnacher, Michael Caldera, Michael Schuster, Cecilia Dominguez Conde, Rene Platzer, Elisabeth Salzer, Thomas Boyer, Han G. Brunner, Judith E. Nooitgedagt-Frons, Estibaliz Iglesias, Angela Deya-Martinez, Marisol Camacho-Lovillo, Joerg Menche, Christoph Bock, Johannes B. Huppa, Winfried F. Pickl, Martin Distel, Jeffrey A. Yoder, David Traver, Karin R. Engelhardt, Tobias Linden, Leo Kager, J. Thomas Hannich, Alexander Hoischen, Sophie Hambleton, Sabine Illsinger, Lydie Da Costa, Kerstin Kutsche, Zahra Chavoshzadeh, Jaap D. van Buul, Jordi Anton, Joan Calzada-Hernandez, Olaf Neth, Julien Viaud, Akihiko Nishikimi, Loic Dupre, Kaan Boztug
Summary: This study reveals that DOCK11 regulates T-cell shape and migration as well as erythroid development. Inherited loss-of-function variants in DOCK11 resulted in early-onset severe immune dysregulation and normocytic anemia.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Abdulrahman Mujalli, Julien Viaud, Sonia Severin, Marie-Pierre Gratacap, Gaetan Chicanne, Karim Hnia, Bernard Payrastre, Anne-Dominique Terrisse
Summary: Phosphoinositides (PIs) are important for regulating intracellular signaling and membrane trafficking. This study reveals a previously unknown pool of phosphatidylinositol 3-monophosphate (PI3P) in the outer leaflet of resting platelet plasma membrane. The presence of external PI3P is influenced by certain kinases and can bind to PI3P-binding proteins, suggesting a potential role in platelet communication and protein elimination.
Article
Medicine, Research & Experimental
Mathieu Cinato, Laurie Guitou, Amira Saidi, Andrei Timotin, Erwan Sperazza, Thibaut Duparc, Sergey N. Zolov, Sai Srinivas Panapakkam Giridharan, Lois S. Weisman, Laurent O. Martinez, Jerome Roncalli, Oksana Kunduzova, Helene Tronchere, Frederic Boal
Summary: The study highlights the inhibitory effects of Apilimod on cardiac fibrotic remodeling, controlling the TGF beta signaling pathway to prevent adverse remodeling. It also suggests a novel function for PIKfyve in regulating myocardial fibrosis and TGF beta pathway.
