期刊
BIOESSAYS
卷 32, 期 6, 页码 505-513出版社
WILEY
DOI: 10.1002/bies.200900169
关键词
gene regulatory network; nested feedback loop; static network motif; temporal sequence of network motifs; time-varying network
资金
- Korea Ministry of Education, Science & Technology (MEST) [2010-0017662]
- Basic Research Laboratory (BRL) [2009-0086964]
- Systems Biology [20100002160]
- Nuclear Research [M20708000001-07B0800-00110]
- 21C Frontier Microbial Genomics and Application Center Program [11-2008-10-004-00]
- World Class University (WCU) [232-2008-000-10218-0]
- GIST
- National Research Foundation of Korea [11-2008-10-004-00] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
The identification of network motifs has been widely considered as a significant step towards uncovering the design principles of biomolecular regulatory networks. To date, time-invariant networks have been considered. However, such approaches cannot be used to reveal time-specific biological traits due to the dynamic nature of biological systems, and hence may not be applicable to development, where temporal regulation of gene expression is an indispensable characteristic. We propose a concept of a temporal sequence of network motifs, a sequence of network motifs in active sub-networks constructed over time, and investigate significant network motifs in the active temporal sub-networks of Drosophila melanogaster. Based on this concept, we find a temporal sequence of network motifs which changes according to developmental stages and thereby cannot be identified from the whole static network. Moreover, we show that the temporal sequence of network motifs corresponding to each developmental stage can be used to describe pivotal developmental events.
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