期刊
BIOESSAYS
卷 32, 期 9, 页码 800-807出版社
WILEY
DOI: 10.1002/bies.201000048
关键词
DNA replication; Geminin; homeodomain; Hox; transcription
资金
- ANR
- FRM
- CEFIPRA
- ARC
Hox proteins are well-known as developmental transcription factors controlling cell and tissue identity, but recent findings suggest that they are also part of the cell replication machinery. Hox-mediated control of transcription and replication may ensure coordinated control of cell growth and differentiation, two processes that need to be tightly and precisely coordinated to allow proper organ formation and patterning. In this review we summarize the available data linking Hox proteins to the replication machinery and discuss the developmental and pathological implications of this new facet of Hox protein function.
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