Article
Chemistry, Multidisciplinary
Candela Melendreras, Ana Soldado, Jose M. Costa-Fernandez, Alberto Lopez, Francisco Ferrero
Summary: This work presents a miniaturized, low-cost, and user-friendly near-infrared spectroscopy (NIRS) measurement system for alfalfa quality control. It addresses the significant challenge faced by dairy farm technicians and producers to quickly and accurately assess the forage quality on their farms.
APPLIED SCIENCES-BASEL
(2023)
Article
Biotechnology & Applied Microbiology
Xiaojing He, Zhining Li, Mengling Ye, Chen Zhao, Siyi Wu, Yi Qin, Youyuan Guo, Lu Zhang, Fei Lin
Summary: Researchers have developed upconversion nanoparticles (UCNPs) for precise release of dexamethasone (DEX) and fluorescence indicator targeting. The encapsulation of DEX in the UCNPs significantly improves drug utilization, water solubility and bioavailability, enhancing the anti-inflammatory performance in clinical settings.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Chemistry, Analytical
Lan-Fang Pang, Yu-Cheng Sun, Xiao-Feng Guo, Hong Wang
Summary: In this study, carbon dots with near-infrared fluorescence were prepared using a hydrothermal method and successfully used for quantitative determination of H2S and imaging of endogenous H2S efflux from cell membrane. The NIR-CDs showed specific location on cell membrane and offered a new strategy for the design of targeted fluorescent probes in different functional regions of the cell membrane in the future.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Review
Biochemistry & Molecular Biology
Zhipeng Zhang, Peiyao Chen, Yao Sun
Summary: Near-infrared (NIR) fluorescence is a promising imaging technique that is noninvasive, highly sensitive, and high-resolution. Enzymes are ideal triggers for activating NIR fluorescent probes, which have better signal-to-noise ratio compared to Always-On probes. This review provides an overview of enzyme-activatable NIR fluorescent probes, focusing on design strategies, sensing mechanisms, and current challenges in construction.
Article
Instruments & Instrumentation
Tongshuai Han, Jin Liu, Rong Liu, Wenliang Chen, Mingfei Yao, Xueyu Liu, Qing Ge, Zengfu Zhang, Chenxi Li, Yuxiang Wang, Picheng Zhao, Di Sun, Kexin Xu
Summary: This study investigates a measurement strategy based on near-infrared spectroscopy to effectively detect glucose signals in a noninvasive manner. The strategy includes a customized detector and a fixing and aiming method to minimize the influence of human variations and probing conditions. Experimental results demonstrate the feasibility of the proposed strategy in detecting glucose in vivo.
APPLIED SPECTROSCOPY
(2022)
Article
Chemistry, Multidisciplinary
Ning Li, Chen Li, Boying Li, Chaoqun Li, Qi Zhao, Zhongming Huang, Yue Shu, Xiongwei Qu, Baiqi Wang, Shengliang Li, Chengfen Xing
Summary: In this study, biomimetic conjugated oligomeric nanoparticles were developed to modulate blood glucose homeostasis by activating calcium channels with near-infrared laser. The results showed that these nanoparticles effectively regulated glucose metabolism, holding promise for diabetes treatment.
Article
Chemistry, Physical
Sae Tanaka, Roumiana Tsenkova, Masato Yasui
Summary: Glucose plays important roles in energy supply, protein glycosylation, and drought tolerance in living organisms. Understanding the interaction between carbohydrates and water molecules is essential for research purposes. Near-infrared spectroscopy can be utilized to study aqueous solutions of carbohydrates.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Multidisciplinary Sciences
Mariana Santos-Rivera, Amelia Woolums, Merrilee Thoresen, Ellianna Blair, Victoria Jefferson, Florencia Meyer, Carrie K. Vance
Summary: This study analyzed the NIR spectral profile of blood plasma from dairy calves infected with M. haemolytica to diagnose BRD, with high accuracy, sensitivity, and specificity. The results demonstrate the potential of NIRS as a diagnostic and monitoring tool of BRD in cattle over time, showing physiological and biochemical changes in the bloodstream during infection.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
G. J. Zhang, Y. Wang, Y. H. Yan, M. H. Hall, D. J. Undersander, D. K. Combs
Summary: This study aimed to compare the effectiveness of different bag types in estimating undigested forage neutral detergent fiber (uNDF) in the in situ reference method. The results showed that the estimated iNDF content in alfalfa samples from Wisconsin and Pennsylvania after 240 hours of incubation was significantly higher in small bags compared to large bags, indicating that near-infrared spectroscopy can be used to quickly and accurately predict iNDF content in alfalfa.
Article
Engineering, Environmental
Guolin Zheng, Zhe Jiang, Yifan Cui, Man Zhou, Yuanyuan Yu, Ping Wang, Qiang Wang
Summary: Enzymes, as green catalysts, have attracted extensive interest due to their high activity and substrate specificity. However, the enzymes' activities are sensitive to external environments, requiring efficient strategies for modulating their activity and stability. Near-infrared (NIR) light-controlled activities provide noninvasive and convenient controllability advantages, with intense penetration and low phototoxicity. This study demonstrates the use of supersmall platinum nanoparticles (Pt-NPs) deposited on laccase to enhance enzymatic activity under NIR light, and showcases the potential for manipulating enzyme activity and understanding enzyme-metal nano-bio hybrid catalysts.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Simon-Okomo Aloo, Fred-Kwame Ofosu, Deog-Hwan Oh
Summary: The study found that sprouts are healthier and more nutritionally rich than raw seeds, with stronger antioxidant, antidiabetic, and antiobesity activities. Sprouting leads to higher levels of metabolites in sprouts compared to raw seeds, making it a suitable technique for altering the functional properties of edible seeds depending on the desired activity.
Article
Chemistry, Analytical
Murad Althobaiti
Summary: This study investigates the feasibility of using dual-NIR channels for patients with different skin colors. By utilizing a Monte Carlo simulation model, the study analyzes the impact of different skin colors on the corresponding sensor. The findings contribute to the design of a compact and non-invasive NIR glucose sensor for patients with different skin colors.
Article
Chemistry, Analytical
Helena Cano-Garcia, Rohit Kshirsagar, Roberto Pricci, Ahmed Teyeb, Fergus O'Brien, Shimul Saha, Panagiotis Kosmas, Efthymios Kallos
Summary: The study reported measurement results of non-invasive glucose sensing using a novel multiwavelength approach that combined radio frequency and near infrared signals. Changes in glucose solutions with varying concentrations were successfully detected, and it was shown for the first time that combining transmission data from distinct electromagnetic bands, accompanied by machine learning algorithms, can achieve greater accuracy in predicting glucose levels compared to single modality systems.
Article
Thermodynamics
Saad A. Jajja, Brian M. Fronk
Summary: This study characterized the thermal-hydraulic behavior of carbon dioxide near the critical point in rectangular microchannels with uniform heating limited to a single wall. The experiments revealed that existing supercritical heat transfer correlations developed for uniform wall heating conditions did not accurately predict heat transfer for single wall heating boundary conditions.
INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER
(2021)
Article
Engineering, Electrical & Electronic
Yuyang Sun, Helena Cano-Garcia, Efthymios Kallos, Fergus O'Brien, Adeyemi Akintonde, Diana-Elena Motei, Oana Ancu, Richard William Alexander Mackenzie, Panagiotis Kosmas
Summary: By combining multiple sensor data with machine learning techniques, we have developed an accurate fully noninvasive glucose monitoring model. The model achieved high prediction accuracy on a dataset of clinical subjects and holds promise for practical applications in glucose monitoring.
IEEE SENSORS JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Yohann Rautureau, Marianne Berlatie, Daniel Rivas, Kurunradeth Uy, Alexandre Blanchette, Geraldine Miquel, Marie-Eve Higgins, Melanie Mecteau, Audrey Nault, Louis Villeneuve, Veronique Lavoie, Gabriel Theberge-Julien, Genevieve Brand, Line Lapointe, Maxime Denis, Camille Rosa, Annik Fortier, Lucie Blondeau, Marie-Claude Guertin, Marie-Pierre Dube, Eric Thorin, Jonathan Ledoux, David Rhainds, Eric Rheaume, Jean-Claude Tardif
Summary: ADCY9 gene plays a role in determining atherosclerotic outcomes in patients and in mice it has been shown to potentiate endothelial function and inhibit atherogenesis. The inactivation of Adcy9 leads to increased cAMP accumulation in response to certain activators and enhances endothelial-dependent vasodilation. Additionally, ADCY9 can regulate endothelial permeability and actin cytoskeleton in response to thrombin, affecting the development of atherosclerosis.
CARDIOVASCULAR RESEARCH
(2023)
Article
Genetics & Heredity
Amke Caliebe, Fasil Tekola-Ayele, Burcu F. Darst, Xuexia Wang, Yeunjoo E. Song, Jiang Gui, Ronnie A. Sebro, David J. Balding, Mohamad Saad, Marie-Pierre Dube
Summary: This paper explores methods and tools for inclusive genetic epidemiology research, emphasizing the importance of distinguishing socially defined population categorizations from genetic ancestry in the design, analysis, and interpretation of research findings.
GENETIC EPIDEMIOLOGY
(2022)
Article
Multidisciplinary Sciences
Gemma Cadby, Corey Giles, Phillip E. Melton, Kevin Huynh, Natalie A. Mellett, Thy Duong, Anh Nguyen, Michelle Cinel, Alex Smith, Gavriel Olshansky, Tingting Wang, Marta Brozynska, Mike Inouye, Nina S. McCarthy, Amir Ariff, Joseph Hung, Jennie Hui, John Beilby, Marie-Pierre Dube, Gerald F. Watts, Sonia Shah, Naomi R. Wray, Wei Ling Florence Lim, Pratishtha Chatterjee, Ian Martins, Simon M. Laws, Tenielle Porter, Michael Vacher, Ashley Bush, Christopher C. Rowe, Victor L. Villemagne, David Ames, Colin L. Masters, Kevin Taddei, Matthias Arnold, Gabi Kastenmueller, Kwangsik Nho, Andrew J. Saykin, Xianlin Han, Rima Kaddurah-Daouk, Ralph N. Martins, John Blangero, Peter J. Meikle, Eric K. Moses
Summary: This study integrated lipidomics and genomics to investigate the genetic architecture of lipid metabolism and identified genetic variants associated with coronary artery disease (CAD). Through GWAS and validation in multiple cohorts, a large number of genetic loci associated with lipid species were identified. These findings have important implications for understanding the pathogenesis of atherosclerosis and CAD, as well as other complex diseases.
NATURE COMMUNICATIONS
(2022)
Article
Cardiac & Cardiovascular Systems
Marie-Pierre Dube, Olympe Chazara, Audrey Lemacon, Geraldine Asselin, Sylvie Provost, Amina Barhdadi, Louis-Philippe Lemieux Perreault, Ian Mongrain, Quanli Wang, Keren Carss, Dirk S. Paul, Jonathan W. Cunningham, Jean Rouleau, Scott D. Solomon, John J. McMurray, Salim Yusuf, Chris B. Granger, Carolina Haefliger, Simon de Denus, Jean-Claude Tardif
Summary: The study aims to identify genetic predictors of heart failure progression and the efficacy and safety of candesartan treatment. The researchers found a genetic variant near the GFRA2 gene that may be associated with cardiovascular events in heart failure patients with preserved ejection fraction. Further replication studies are needed to validate these findings.
Article
Multidisciplinary Sciences
Isabelle Peretz, Jay Ross, Cynthia Bourassa, Louis-Philippe Lemieux Perreault, Patrick A. Dion, Michael W. Weiss, Mihaela Felezeu, Guy A. Rouleau, Marie-Pierre Dube
Summary: This study examines the association between variants in the FOXP2 gene and congenital amusia, and finds that FOXP2 variants are not related to amusia. This has implications for distinguishing between musicality and language.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Maxine Sun, Marie-Pierre Dube, Thomas Hennessy, Carl J. Schultz, Amina Barhdadi, David Rhainds, Graham S. Hillis, Jean-Claude Tardif
Summary: This study conducted a combined analysis of data from the COLCOT and LoDoCo-MI trials to assess the effect of low-dose colchicine on hs-CRP in patients with acute MI. The results showed that low-dose colchicine was not significantly associated with post-treatment hs-CRP as a continuous variable, but it was associated with increased odds of achieving post-treatment hs-CRP values <= 1.0 mg/L. Reduction of inflammation may be a key component in the clinical efficacy of low-dose colchicine for reducing the risk of recurrent cardiovascular events following MI.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Plant Sciences
Christian Silva, Jaclyn A. Adaskaveg, Saskia D. Mesquida-Pesci, Isabel B. Ortega-Salazar, Sivakumar Pattathil, Lisha Zhang, Michael G. Hahn, Jan A. L. van Kan, Dario Cantu, Ann L. T. Powell, Barbara Blanco-Ulate
Summary: Postharvest fungal pathogen Botrytis cinerea actively induces ripening in tomato fruit to facilitate infection, depending on the presence of two fungal polygalacturonases. It accelerates external coloration, ethylene production, and softening in unripe fruit while upregulating host genes involved in ripening processes. Glycomic analysis also showed similar changes in cell wall polysaccharides between infected unripe fruit and ripe healthy fruit. The failure to accelerate ripening severely inhibits fungal survival on unripe fruit.
Article
Genetics & Heredity
Marc-Andre Legault, Amina Barhdadi, Isabel Gamache, Audrey Lemacon, Louis-Philippe Lemieux Perreault, Jean-Christophe Grenier, Marie-Pierre Sylvestre, Julie G. Hussin, David Rhainds, Jean-Claude Tardif, Marie-Pierre Dube
Summary: Genetic variants in drug targets can predict the long-term effect of drugs. In this study, we examined how sex and body mass index (BMI) influence the effect of genetically predicted lower CETP levels on biomarkers and cardiovascular outcomes. Our findings suggest that female sex and lower BMI are associated with beneficial lipid biomarker profiles when CETP concentrations are genetically reduced. However, these modifying effects did not extend to sex differences in cardiovascular outcomes. These results provide valuable insights into the clinical implications of CETP inhibitors and can support precision medicine applications.
GENETIC EPIDEMIOLOGY
(2023)
Article
Medicine, General & Internal
D. Pellerin, M. C. Danzi, C. Wilke, M. Renaud, S. Fazal, M. -J Dicaire, C. K. Scriba, C. Ashton, C. Yanick, D. Beijer, A. Rebelo, C. Rocca, Z. Jaunmuktane, J. A. Sonnen, R. Lariviere, D. Genis, L. Molina Porcel, K. Choquet, R. Sakalla, S. Provost, R. Robertson, X. Allard-Chamard, M. Tetreault, S. J. Reiling, S. Nagy, V Nishadham, M. Purushottam, S. Vengalil, M. Bardhan, A. Nalini, Z. Chen, J. Mathieu, R. Massie, C. H. Chalk, A. -L Lafontaine, F. Evoy, M. -F Rioux, J. Ragoussis, K. M. Boycott, M. -P Dube, A. Duquette, H. Houlden, G. Ravenscroft, N. G. Laing, P. J. Lamont, M. A. Saporta, R. Schuele, L. Schoels, R. La Piana, M. Synofzik, S. Zuchner, B. Brais
Summary: A repeat expansion in the FGF14 gene was found to be associated with late-onset cerebellar ataxias (LOCAs) in French Canadian and German populations as well as in Australian and Indian patients. This discovery provides important insights for further research and diagnosis of LOCAs.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Psychology, Clinical
Alexandra Connor, Louisia Starnino, Lambert Busque, Jean-Claude Tardif, Vincent Bourgoin, Marie-Pierre Dube, David Busseuil, Bianca D'Antono
Summary: Childhood maltreatment is associated with shorter leukocyte telomere length (LTL), which may increase the risk of coronary artery disease (CAD) through emotional dysregulation. The relation between maltreatment and LTL is not influenced by symptoms of anxiety, depression, or perceived stress. Stress perception partially mediates the association between childhood maltreatment and LTL.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Oncology
Maxine Sun, Marie-Christyne Cyr, Johanna Sandoval, Louis-Philippe Lemieux Perreault, Lambert Busque, Jean-Claude Tardif, Marie-Pierre Dube
Summary: This study analyzed a cohort of 48,919 cancer patients from the UK Biobank and found that individuals with mosaic chromosomal alterations (mCA) are at an increased risk of death from cardiovascular disease (CVD), particularly in patients with kidney cancer and breast cancer.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Article
Medicine, Research & Experimental
Jessica Hindi, Marc-Olivier Pilon, Maxime Meloche, Gregoire Leclair, Essaid Oussaid, Isabelle St-Jean, Martin Jutras, Marie-Josee Gaulin, Ian Mongrain, David Busseuil, Jean Lucien Rouleau, Jean-Claude Tardif, Marie-Pierre Dube, Simon de Denus
Summary: Females have a higher risk of adverse drug reactions, possibly due to sex-related differences in drug concentrations. This study aimed to investigate the factors that could explain these differences in concentrations and dosing for metoprolol and oxypurinol. The analysis of two cross-sectional studies showed that females had higher dose-adjusted concentrations of both metoprolol and oxypurinol, and sex remained an independent predictor of metoprolol concentrations. This suggests the need for sex-specific dosing requirements for these drugs.
CTS-CLINICAL AND TRANSLATIONAL SCIENCE
(2023)
Article
Hematology
Marie-France Gagnon, Sylvie Provost, Maxine Sun, Sami Ayachi, Manuel Buscarlet, Luigina Mollica, Natasha Szuber, Marie-Pierre Dube, Lambert Busque
Summary: Blood cell production is a complex process influenced by genetic and acquired factors. However, there is limited data on how these factors interact in the context of aging, which is associated with a myeloid proliferation bias. In a study of 2996 women aged 55-101 years, researchers found that aging is associated with increased neutrophil and monocyte counts and decreased lymphocyte counts. Neutrophil counts were influenced by genetic variants and chronic diseases, but the contribution of genetic factors decreased with age. The presence of cardiometabolic comorbidities further increased myeloid-derived cell counts, but this was not correlated with clonal hematopoiesis. These findings suggest that cell-extrinsic factors play a role in the myeloid shift associated with aging and age-related diseases.
Meeting Abstract
Cardiac & Cardiovascular Systems
Maxine Sun, Marie-Christyne Cyr, Johanna Sandoval, Louis-Philippe Lemieux Perreault, Lambert Busque, Jean-Claude Tardif, Marie-Pierre Dube
Correction
Cardiac & Cardiovascular Systems
Jean Claude Tardif, Marc A. Pfeffer, Simon Kouz, Wolfgang Koenig, Aldo P. Maggioni, John J. V. McMurray, Vincent Mooser, David D. Waters, Jean C. Gregoire, Philippe L. L'Allier, Wouter J. Jukema, Harvey D. White, Therese Heinonen, Donald M. Black, Fouzia Laghrissi-Thode, Sylvie Levesque, Marie Claude Guertin, Marie Pierre Dube
EUROPEAN HEART JOURNAL
(2022)
