Article
Chemistry, Multidisciplinary
David Roesel, Maksim Eremchev, Chetan S. Poojari, Jochen S. Hub, Sylvie Roke
Summary: A direct link between membrane potential fluctuations and divalent ion transport has been discovered, and it has been shown through molecular dynamics simulations and experimental results that pore formation induced by an ion-induced electrostatic field is a viable mechanism for unassisted ion transport.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Physics, Fluids & Plasmas
Q. Hu, R. P. Joshi
Summary: Recent reports suggest that nanoparticle clusters near cell membranes can enhance local electric fields and lead to increased electroporation, especially under pulsed conditions. The results indicate a significant increase in transmembrane potentials (TMP) with the presence of multiple NP clusters, enabling enhanced poration even at sites far from the poles. Additionally, nonuniform distributions can facilitate poration at regions distant from the poles.
Article
Biology
Tim J. van der Zee, Arthur D. Kuo
Summary: Muscles consume metabolic energy when activated quickly during cyclic force production, adding significantly to overall cost. The cost, relative to mechanical work, increases with waveform frequency due to additional active calcium transport. This force-rate cost has implications for movements requiring rapid muscle activation, such as locomotion.
JOURNAL OF EXPERIMENTAL BIOLOGY
(2021)
Article
Biology
Sageanne Senneff, Madeleine M. Lowery
Summary: This study presents a mathematical model to investigate the role of mitochondria in regulating calcium, ATP, and force generation. The model also explores the impact of mitochondrial dysfunction on excitation-contraction coupling and the mechanisms of cellular dysfunction during sustained contractions.
BULLETIN OF MATHEMATICAL BIOLOGY
(2022)
Article
Computer Science, Information Systems
Eva Pirc, Damijan Miklavcic, Katja Ursic, Gregor Sersa, Matej Rebersek
Summary: Significant progress has been made in the research of high-frequency electroporation, with the development of a new asymmetric bipolar pulse generator showing comparable efficacy to classical electric pulses in in vivo electrochemotherapy. Additional investigation is needed in pulse parameters and therapeutic effects of high-frequency electroporation pulses.
Article
Chemistry, Physical
Min Li, WenCai Lu, John ZengHui Zhang
Summary: The study successfully extended the coarse-graining strategy to ultra-coarse-grained models and effectively parameterized liquid water, accurately predicting some important properties of liquid water. Additionally, two polarizable states of UCG molecules were observed after system equilibration. The results demonstrate that the proposed UCG models can accelerate liquid water simulation effectively.
JOURNAL OF CHEMICAL PHYSICS
(2021)
Article
Biochemistry & Molecular Biology
Cecilia Leijding, Ida Viken, Joseph D. D. Bruton, Daniel C. C. Andersson, Arthur J. J. Cheng, Hakan Westerblad
Summary: During the initial phase of fatigue, tetanic force decreases despite increasing tetanic cytosolic calcium concentration. However, the increase in calcium concentration has positive effects on force in early fatigue.
Article
Biochemistry & Molecular Biology
Monika Sztretye, Zoltan Singlar, Nyamkhuu Ganbat, Dana Al-Gaadi, Kitti Szabo, Zoltan Marton Kohler, Laszlo Dux, Aniko Keller-Pinter, Laszlo Csernoch, Peter Szentesi
Summary: The remodelling of the extracellular matrix plays a crucial role in skeletal muscle development and regeneration. The decreased expression of Syndecan-4 leads to reduced muscle performance and altered calcium homeostasis in mice. These effects are observed at both young and aged stages.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Zofia Lapinska, Urszula Szwedowicz, Anna Choromanska, Jolanta Saczko
Summary: Gynecological carcinomas are a growing concern and current treatment methods have limited efficacy. Electroporation-based therapies, which reduce drug dosage and increase effectiveness, have gained attention. This review provides an overview of the mechanisms and current applications of electroporation in the treatment of gynecological neoplasms.
Article
Neurosciences
Haruyuki Kamiya
Summary: This article investigates the passive subthreshold voltage signaling in axons and its impact on transmitter release. The simulation results show that subthreshold voltage signals can reduce calcium currents by decreasing the amplitude of action potentials and modulate synaptic function by enhancing transmitter release.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Physics, Fluids & Plasmas
Matea Santiago, Kevin A. Mitchell, Shilpa Khatri
Summary: This paper presents a numerical method to study the pulsing behavior of soft corals and explores its relationship with photosynthesis through mathematical modeling and numerical simulations. The study finds that fluid dynamics significantly affect photosynthesis, and that the Reynolds number has advantages for mixing and photosynthesis.
PHYSICAL REVIEW FLUIDS
(2022)
Article
Chemistry, Medicinal
Eivina Radzeviciute-Valciuke, Augustinas Zelvys, Egle Mickeviciute, Jovita Gecaite, Aukse Zinkeviciene, Veronika Malysko-Ptasinske, Vytautas Kaseta, Jurij Novickij, Tatjana Ivaskiene, Vitalij Novickij
Summary: Calcium electroporation (CaEP) is a promising treatment for cancer, as it effectively eliminates tumors and enhances the immune response. This study presents both microsecond and nanosecond protocols for CaEP, demonstrating their efficacy in tumor eradication and improved survival rates in mice. CaEP treatment leads to an increased percentage of CD4(+) and CD8(+) central memory T cells, reduced splenic myeloid-derived suppressor cells, and elevated levels of antitumor antibodies.
Review
Biochemistry & Molecular Biology
Michael Attwaters, Simon M. Hughes
Summary: Skeletal muscle can grow in three ways: by generating new syncytial fibers, adding nuclei from muscle stem cells to existing fibers, or increasing cytoplasmic volume/nucleus. Evidence suggests that the latter two processes contribute to exercise-induced growth. Fiber growth requires an increase in sarcolemmal surface area and cytoplasmic volume at different rates.
Review
Computer Science, Information Systems
Mohammad Reza Qasemian Reyhan Abadi, Mohammad Hoseintabar Marzebali, Vahid Abolghasemi, Mohammad Hossein Anisi
Summary: Electroporation is an important microbiology technique with wide applications in various industries and medical fields. This study reviews the literature on pulse power and pulse generators for the electroporation process, discussing their characteristics and comparing different groups of pulse generators.
Article
Chemistry, Physical
Mehdi Yoosefian, Batool Tajaddini, Saeid Ahmadzadeh, Maryam Zeraati-Moghani, Zahra Pakdin-Parizi
Summary: Drinking excessive alcohol can cause chronic diseases and serious problems such as heart disease, high blood pressure, stroke, digestive problems, and liver disease. A molecular dynamics simulation study found that ethanol blocks calcium channels and interferes with calcium ion passage. Furthermore, calcium ions have a greater tendency to interact with residues inside the protein channel in the presence of ethanol.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Biochemistry & Molecular Biology
Iurii Semenov, Maura Casciola, Bennet L. Ibey, Shu Xiao, Andrei G. Pakhomov
BIOELECTROCHEMISTRY
(2018)
Article
Biochemistry & Molecular Biology
Elena C. Gianulis, Maura Casciola, Shu Xiao, Olga N. Pakhomova, Andrei G. Pakhomov
BIOELECTROCHEMISTRY
(2018)
Article
Biochemistry & Molecular Biology
Andrei G. Pakhomov, Sergey Grigoryev, Iurii Semenov, Maura Casciola, Chunqi Jiang, Shu Xiao
BIOELECTROCHEMISTRY
(2018)
Article
Cardiac & Cardiovascular Systems
Jan E. Azarov, Iurii Semenov, Maura Casciola, Andrei G. Pakhomov
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
(2019)
Article
Multidisciplinary Sciences
Alessandra Rossi, Olga N. Pakhomova, Andrei G. Pakhomov, Samantha Weygandt, Anna A. Bulysheva, Len E. Murray, Peter A. Mollica, Claudia Muratori
SCIENTIFIC REPORTS
(2019)
Article
Biochemistry & Molecular Biology
Maura Casciola, Shu Xiao, Francesca Apollonio, Alessandra Paffi, Micaela Liberti, Claudia Muratori, Andrei G. Pakhomov
CELLULAR AND MOLECULAR LIFE SCIENCES
(2019)
Article
Biochemistry & Molecular Biology
Andrei G. Pakhomov, Shu Xiao, Vitalij Novickij, Maura Casciola, Iurii Semenov, Uma Mangalanathan, Vitalii Kim, Christian Zemlin, Esin Sozer, Claudia Muratori, Olga N. Pakhomova
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2019)
Article
Multidisciplinary Sciences
Elena C. Gianulis, Maura Casciola, Carol Zhou, Enbo Yang, Shu Xiao, Andrei G. Pakhomov
SCIENTIFIC REPORTS
(2019)
Article
Oncology
Alessandra Rossi, Olga N. Pakhomova, Peter A. Mollica, Maura Casciola, Uma Mangalanathan, Andrei G. Pakhomov, Claudia Muratori
Article
Biochemistry & Molecular Biology
Olga Michel, Andrei G. Pakhomov, Maura Casciola, Jolanta Saczko, Julita Kulbacka, Olga N. Pakhomova
BIOELECTROCHEMISTRY
(2020)
Article
Biochemistry & Molecular Biology
Wenfei Bo, Mantas Silkunas, Uma Mangalanathan, Vitalij Novickij, Maura Casciola, Iurii Semenov, Shu Xiao, Olga N. Pakhomova, Andrei G. Pakhomov
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Andrei G. Pakhomov, Olga N. Pakhomova
BIOELECTROCHEMISTRY
(2020)
Article
Biochemistry & Molecular Biology
Vitalii Kim, Emily Gudvangen, Oleg Kondratiev, Luis Redondo, Shu Xiao, Andrei G. Pakhomov
Summary: The research investigated the effects of PEF therapy on the excitation thresholds of nerve fibers and different pulse parameters, revealing that nanosecond-range PEF has a higher excitation threshold for nerve fibers, with symmetrical bipolar nsPEF being the least efficient, and brief bursts of pulses being the most effective in reducing neuromuscular stimulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Aleh Kandratsyeu, Uladzimir Sabaleuski, Luis Redondo, Andrei G. Pakhomov
Summary: This article introduces a new pulsed generator for biomedical and biotechnology applications, with the capability to apply various pulse shapes to biological loads, high voltage, and high frequency, controlled via a computer user interface, providing flexibility in pulse generation by adjusting pulse width, polarity, and amplitude. The generator also allows operation in burst mode up to 5 MHz in four independent channels.
APPLIED SCIENCES-BASEL
(2021)
Article
Biochemistry & Molecular Biology
Emily Gudvangen, Uma Mangalanathan, Iurii Semenov, Allen S. Kiester, Mark A. Keppler, Bennett L. Ibey, Joel N. Bixler, Andrei G. Pakhomov
Summary: Cancer ablation therapies aim to efficiently destroy cancer cells with minimal damage to healthy tissues. This study found that nanosecond pulsed electric field (nsPEF) is a promising ablation modality due to its selectivity and reduced side effects. By comparing the effects of PEF on different types of esophageal cells, it was discovered that normal epithelial cells were less sensitive to PEF compared to pre-malignant cells, while randomly oriented smooth muscle cells were more sensitive. Additionally, aligning smooth muscle cells with the electric field reduced damage caused by nsPEF ablation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
