期刊
BIOELECTROCHEMISTRY
卷 77, 期 2, 页码 94-99出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.bioelechem.2009.06.016
关键词
Formaldehyde; Prodrugs; Glioblastoma; Butyric acid; Carbon nanotubes; Screen printed electrodes
This paper reports the development of an electrochemical biosensor for the detection of formaldehyde in aqueous solution, based on the coupling of the enzyme formaldehyde dehydrogenase and a carbon nanotubes (CNT)-modified screen-printed electrode (SPE). We monitored the amperometric response to formaldehyde released from U251 human glioblastoma cells situated in the biosensor chamber in response to treatment with various anticancer prodrugs of formaldehyde and butyric acid. The current response was higher for prodrugs that release two molecules of formaldehyde (AN-193) than for prodrugs that release only one molecule of formaldehyde (AN-1. AN-7). Homologous prodrugs that release one (AN-88) or two (AN-191) molecules of acetaldehyde, showed no signal. The sensor is rapid, sensitive, selective, inexpensive and disposable, as well as simple to manufacture and operate. (c) 2009 Elsevier B.V. All rights reserved.
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