Article
Chemistry, Physical
Khalil Chennit, Yannick Coffinier, Shuo Li, Nicolas Clement, Agnes Anne, Arnaud Chovin, Christophe Demaille
Summary: This paper reports the fabrication and electrochemical interrogation of very high density single-antibody nanoarrays. The occupancy of nanodots by single antibody molecules is demonstrated using ensemble scale interrogation and nanoscale interrogation techniques. The possibility of using single-antibody nanoarrays for digital electrochemical immunoassays is evidenced by experiments involving competitive adsorption of antibodies.
Article
Biochemistry & Molecular Biology
Thuan-Nguyen Pham-Truong, Jalal Ghilane
Summary: This work investigated the localized electrochemical behavior of a redox molecule in an ionic liquid using scanning electrochemical microscopy. The electrochemical response of a ferrocenyl-imidazolium redox mediator was studied on a conducting and insulating substrate in an undiluted ionic liquid. The approach curves displayed different behaviors on the two substrates, with positive feedback on the conducting substrate and varying shapes on the insulating substrate depending on the approach speed. Thin film behavior was observed at very close distances between the UME and the insulating substrate.
Article
Electrochemistry
Inga Morkvenaite-Vilkonciene, Aura Kisieliute, Wojciech Nogala, Anton Popov, Benediktas Brasiunas, Mindaugas Kamarauskas, Arunas Ramanavicius, Steven Linfield, Almira Ramanaviciene
Summary: In this research, an electrochemical sandwich immunoassay using scanning electrochemical microscopy on a gold micro-disc array was proposed for the detection of human growth hormone. It was shown that hGH concentrations as low as 40 nM could be detected using this method.
ELECTROCHIMICA ACTA
(2023)
Article
Chemistry, Physical
Arunas Ramanavicius, Inga Morkvenaite-Vilkonciene, Urte Samukaite-Bubniene, Jurate Jolanta Petroniene, Jurgis Barkauskas, Povilas Genys, Vilma Ratautaite, Roman Viter, Igor Iatsunskyi, Almira Ramanaviciene
Summary: In this research, SECM and EIS techniques were utilized to evaluate the surface characteristics of electrochemical biosensors based on two composite structures modified by carbon on a perforated polycarbonate membrane.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2021)
Article
Chemistry, Analytical
Hyo Jin Gwon, Donghoon Lim, Yunwoo Nam, Hyun S. Ahn
Summary: The development of ultramicroelectrodes and nanoelectrodes has opened up new possibilities for investigating electron transfer phenomena, especially in the field of scanning electrochemical microscopy (SECM). In this study, a multi-channel nanoelectrode bundle was developed for simultaneous electroanalysis of multiple orthogonal redox reactions in one bath, greatly improving the time efficiency of SECM operations. The nanoelectrode bundle was also demonstrated to be a stand-alone microprobe for electroanalytical investigations in small volumes. This development is expected to benefit electrochemical analyses in various systems, particularly those involving SECM and fine spatial control.
ANALYTICA CHIMICA ACTA
(2022)
Review
Chemistry, Physical
Chunlei Yang, Tianhui Su, Yanbo Hua, Liming Zhang
Summary: This review summarizes the latest results of electrochemical scanning probe microscopy techniques in studying the interfacial properties of electrocatalysts and photoelectrodes, and offers some perspectives on future research directions.
Article
Chemistry, Analytical
Andreas Karg, Sebastian Goedrich, Philipp Dennstedt, Nicolas Helfricht, Markus Retsch, Georg Papastavrou
Summary: Scanning electrochemical microscopy (SECM) is a versatile technique for monitoring electrochemical reactions on a highly resolved local scale. This research presents a novel approach to implement a three-electrode setup for SECM in any fluid cell, allowing for high-resolution imaging and equivalent electrochemical performance to macroscopic electrodes.
Article
Biophysics
Xiaocui Zhao, Renkang Zhu, Max Anikovskiy, Qingxi Wu, Zhifeng Ding
Summary: This study utilized scanning electrochemical microscopy (SECM) to quantitatively determine the extracellular H2O2 released from single COS-7 cells with high spatial resolution. The SECM mode allowed for efficient recording of probe approach curves (PACs) and visualization of cell topography simultaneously. The H2O2 concentration at the membrane surface of intact COS-7 cells was determined to be 0.020 mM using experimental PACs and a simulated PAC with a known H2O2 release value. Additionally, confocal microscopy was used to demonstrate the intracellular H2O2 profile, showing that H2O2 generation is centered at the endoplasmic reticula.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Electrochemistry
Rabea Saleh Rabea Bin Sowad, Laszlo Kiss, Andras Kiss
Summary: This paper presents a novel approach to address the challenge of uneven samples in scanning electrochemical microscopy (SECM) by using contact-mode carbon fiber electrodes in potentiometric mode. Comparative analysis of results obtained using the conventional feedback mode and the proposed method demonstrates the efficacy of the proposed method in studying tilted and rugged substrates.
ELECTROCHEMISTRY COMMUNICATIONS
(2023)
Article
Chemistry, Physical
Bastian Krueger, Konstantin Kimon Rucker, Gunther Wittstock
Summary: The reoxidation of Li2O2 in Li-O-2 cells is a high overpotential reaction, and using redox mediators can decrease the overpotential, reduce the formation of reactive oxygen species, and convert all the Li2O2. The rate constants of the redox reaction between the mediators and Li2O2 vary with different electrolytes, and the rate constants in ionic liquids are lower than in ether-based electrolytes.
ACS APPLIED ENERGY MATERIALS
(2022)
Article
Materials Science, Multidisciplinary
A. Renaud, F. Hache, Y. Elkebir, J. Valette, S. Mallarino, D. Trinh, S. Touzain
Summary: In this study, scanning electrochemical microscopy (SECM) combined with an ionic liquid and redox sensor was successfully used to detect and observe the presence of water inside polymeric film at the microscopic scale. The sensitivity of the technique to the presence of water was demonstrated by comparing electrochemical signals obtained on dry and saturated specimens. This research is significant for the development of new methods to locally detect the presence of water in thick polymeric materials and to measure humidity gradient within the material thickness.
MATERIALS CHEMISTRY AND PHYSICS
(2022)
Article
Electrochemistry
Xuanli Liu, Zhenjie Lu, Haoran Pan, Junxia Cheng, Jinxiao Dou, Xinning Huang, Xingxing Chen
Summary: This article emphasizes the importance of avoiding gas evolution in aqueous supercapacitors for safety reasons and introduces the use of high-resolution scanning electrochemical microscopy (SECM) to study the hydrogen evolution side reaction during the charge process. By conducting experiments with functionalized and non-functionalized CNTs, the authors demonstrate the impact of different electrode materials on supercapacitor behavior and apply SECM to investigate local reactivity and conductivity of CNT samples.
ELECTROCHIMICA ACTA
(2022)
Article
Chemistry, Physical
Luolan Wang, Jun Zhang, Zhenhui Wang, Wei Xiong, Shihan Yan, Zhiheng Gong, Nian Zhang, Shijun Zhao, Xinwei Wang, Yan Chen
Summary: This work presents an atomic-scale interfacial engineering strategy to construct highly-active electrocatalyst for glucose detection. Ni(OH)(2) nanosheets are decorated with an ultra-thin layer of Co9S8 using the atomic layer deposition (ALD) technique. After in-situ reconstruction, Ni@Co heterostructure consisting of Ni hydroxide nanosheets and CoOx clusters is obtained, which shows outstanding electrochemical glucose sensing performance. The presence of surface CoOx not only lowers the valence state of Ni, but also facilitates the deprotonation of Ni(OH)(2) to form NiOOH active species for glucose oxidation. The approach used in this work can be adapted to synthesizing high-performance electrocatalysts for other energy and environmental devices.
APPLIED SURFACE SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Song Zhou, Lei Liao, Lan Chen, Baojie Feng, Xiaoyue He, Xuedong Bai, Chuangye Song, Kehui Wu
Summary: This study demonstrates the possibility of maintaining stable in-plane polarization in an extremely thin Bi2WO6 film by using a perfectly lattice-matched NdGaO3 (110) substrate. The residual polarization in this ultrathin film is attributed to the crystal stability of the Bi-O octahedral framework against structural distortions. These findings suggest the potential of the Bi2WO6/NdGaO3 (110) system as a platform for designing low-energy consumption, nonvolatile ferroelectric memories.
Article
Chemistry, Physical
Jingyi Wang, Lei Xie, Linbo Han, Xiaogang Wang, Jianmei Wang, Hongbo Zeng
Summary: The anodic dissolution of chalcopyrite faces the challenge of surface passivation, affecting copper extraction efficiency. The concentrations of Fe2+, Cu2+, and CuxS released during dissolution varied with potential, suggesting that the presence of CuxS is a result of passive layer dissolution. The formation of a hydrophobic passive layer initiates in the active region and covers the chalcopyrite surface in the passive region.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2021)
Correction
Electrochemistry
Bastian Krueger, Luis Balboa, Jan Frederik Dohmann, Martin Winter, Peter Bieker, Gunther Wittstock
Article
Nanoscience & Nanotechnology
Svenja Baues, Heinrich Vocke, Lena Harms, Konstantin K. Ruecker, Michael Wark, Gunther Wittstock
Summary: Metal oxide libraries were generated for photoanodes for the oxygen evolution reaction (OER) through printing of metal salt solutions followed by calcination. The best performing composition was Cu48Ga3W49Ox. Characterization of the electrodes using various techniques was also conducted.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Electrochemistry
Shokoufeh Rastgar, Sebastian Pleis, Yanzhen Zhang, Gunther Wittstock
Summary: A strategy is proposed to generate single microdrops with femtoliter to microliter volumes as a liquid reactor and to guide them towards a reactive surface within a viscous carrier liquid. Reactions of the drop content with the surface are exemplified by exhaustive electrolysis of the reactor content, making use of an ion-conducting pathway through the carrier liquid. The mechanisms by which the redox-active species from the aqueous drop reach the electrode surface were established by a combination of time-lapse microscopy of the drop shape, chronoamperometric recording of the single drop electrolysis, and modelling of the reaction-transport problem, showing that partitioning over the liquid-liquid interface must be a key step in this mechanism. The possibilities of reagent delivery and external triggering of a reaction are expanded by the possibility for controlled addition of further dissolved reactants to the liquid microreactor.
Article
Chemistry, Multidisciplinary
Patricia Scheurle, Andre Maehringer, Tabea Haug, Alexander Biewald, Daniel Axthammer, Achim Hartschuh, Lena Harms, Gunther Wittstock, Dana D. Medina, Thomas Bein
Summary: This study integrated a flexible, electron-rich building block into the backbone of a metal-organic framework with a MOF-74 topology. The resulting structure exhibited an unusual helical rod-like morphology and showed visible light absorption and photoluminescence properties.
CRYSTAL GROWTH & DESIGN
(2022)
Article
Chemistry, Physical
Alex Ricardo Silva Olaya, Franziska Kuehling, Christoph Mahr, Birthe Zandersons, Andreas Rosenauer, Joerg Weissmueller, Gunther Wittstock
Summary: Nanoporous gold (NPG) with less than 1% residual Ag content was studied as an electrocatalyst for the oxidation of methanol, formaldehyde, and formate. The surface structure and oxidation reaction of NPG can be controlled by adjusting the Ag content and potential. Ag has a significant impact on the onset potential and peak current density of the catalytic reaction.
Editorial Material
Electrochemistry
Shokoufeh Rastgar, Sebastian Pleis, Yanzhen Zhang, Gunther Wittstock
Article
Chemistry, Physical
Bastian Krueger, Konstantin Kimon Rucker, Gunther Wittstock
Summary: The reoxidation of Li2O2 in Li-O-2 cells is a high overpotential reaction, and using redox mediators can decrease the overpotential, reduce the formation of reactive oxygen species, and convert all the Li2O2. The rate constants of the redox reaction between the mediators and Li2O2 vary with different electrolytes, and the rate constants in ionic liquids are lower than in ether-based electrolytes.
ACS APPLIED ENERGY MATERIALS
(2022)
Correction
Chemistry, Physical
Alex Ricardo Silva Olaya, Franziska Kuhling, Christoph Mahr, Birthe Zandersons, Andreas Rosenauer, Jorg Weissmueller, Gunther Wittstock
Article
Nanoscience & Nanotechnology
Hyunah Kwon, Hannah-Noa Barad, Alex Ricardo Silva Olaya, Mariana Alarcon-Correa, Kersten Hahn, Gunther Richter, Gunther Wittstock, Peer Fischer
Summary: Plasma treatment of metal nanoparticles formed by physical vapor deposition is a general method to fabricate nanoporous metallic films, which are free of impurities, highly curved ligaments, and nanopores. The films are ultrathin, but robust and well connected, making them highly promising for various applications such as transparent conducting electrodes.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Electrochemistry
Simon Sprengel, Mandana Amiri, Abolfazl Bezaatpour, Sima Nouhi, Svenja Baues, Gunther Wittstock, Michael Wark
Summary: This study proposes a novel hybrid bimetallic organic framework (H-biMOF) as an electrocatalyst for the oxygen evolution reaction (OER) under alkaline conditions. The H-biMOF exhibits excellent catalytic activity in OER, which is attributed to its abundant active sites and suitable mass transport properties.
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2022)
Review
Chemistry, Multidisciplinary
Gunther Wittstock, Marcus Baeumer, Wilke Dononelli, Thorsten Kluener, Lukas Luehrs, Christoph Mahr, Lyudmila Moskaleva, Mehtap Oezaslan, Thomas Risse, Andreas Rosenauer, Anne Staubitz, Joerg Weissmueller, Arne Wittstock
Summary: Nanoporous gold (NPG) is a nanoscale material with a network of metallic struts and interconnected pores formed from gold alloys through oxidative dissolution. It exhibits good catalytic activity, particularly in the aerobic partial oxidation of methanol. This review discusses methods to control NPG morphology and composition, explores mechanistic understanding from quantum chemical studies, and highlights best practices for material preparation and characterization.
Article
Electrochemistry
Sweety Ann Samuel, Gunther Wittstock
Summary: Nanoparticle-imprinted matrices (NAIMs) were prepared by attaching ammonium-terminated SiO2 nanoparticles (NPs) to activated glassy carbon. The selectivity of the polymer matrix towards Au analyte NPs was tuned by conjugate addition of substituted thiols to the matrix. The amount of Au NPs inside the complementary cavities of the NAIMs was quantified by charge transfer during electrodissolution.
Letter
Electrochemistry
Gunther Wittstock
JOURNAL OF SOLID STATE ELECTROCHEMISTRY
(2023)
Article
Chemistry, Physical
Hyunah Kwon, Hannah-Noa Barad, Alex Ricardo Silva Olaya, Mariana Alarcon-Correa, Kersten Hahn, Gunther Richter, Gunther Wittstock, Peer Fischer
Summary: Impurity-free nanoporous gold films with controllable pore sizes are fabricated using a plasma-enabled dry synthetic route, which eliminates sacrificial metals and solution processing. These films possess highly curved ligaments, are remarkably robust, and stable over hundreds of electrochemical cycles. Furthermore, they contain many catalytically active sites, making them highly promising for electrocatalytic applications.
Article
Chemistry, Physical
Svenja Speldrich, Michael Wark, Gunther Wittstock
Summary: Research has found that the application of protective layers to the photoabsorber can improve stability while maintaining favorable absorption characteristics. In this study, protective layers of Bi, Fe, Co, and Ni oxides were used, with Bi oxides showing the best combination of stability and activity, demonstrating their importance in enhancing photoactivity.
ACS APPLIED ENERGY MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Priyanga Kumar, Noel Nesakumar, Jayashree Gopal, Sakthivel Sivasubramanian, Srinivasan Vedantham, John Bosco Balaguru Rayappan
Summary: This study developed an electrochemical biosensor for measuring MG levels in the plasma of type-2 diabetes mellitus patients. The biosensor showed a wide linear concentration range, high sensitivity, and a 90% correlation with ELISA data. It also exhibited a significant correlation with HbA1c and fasting plasma glucose levels.
BIOELECTROCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Cristina Tortolini, Valeria Gigli, Antonio Angeloni, Federico Tasca, Nguyen T. K. Thanh, Riccarda Antiochia
Summary: The development of a novel voltammetric immunosensor for the detection of salivary MMP-8 at the point-of-care is described. The sensor showed good performance and comparable results to the conventional ELISA method when tested in real saliva samples. This biosensor is single-use, cost-effective, and requires a small quantity of test medium and a short preparation time.
BIOELECTROCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Rimsha B. Jamal, Ulrich Bay Gosewinkel, Elena E. Ferapontova
Summary: Pathogen-triggered infections are a severe global threat to human health. Researchers have developed a fast and inexpensive electrocatalytic aptamer assay for the specific and ultrasensitive detection of E. coli, allowing for timely treatment and prevention. The method is fast, sensitive, and can be used in field and point-of-care applications for analysis of bacteria in the human environment.
BIOELECTROCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Miao Liu, Yuwei Wang, Shanshan Tang, Wei Wang, Axin Liang, Aiqin Luo
Summary: An unlabeled ratiometric molecular imprinted electrochemiluminescence sensor was developed for the determination of trace uric acid using MXene@NaAsc, CdSe@ZnS quantum dots, and molecularly imprinted polymer composites modified glass carbon electrode. This sensor, with easy preparation, great selectivity, and excellent sensitivity, successfully detected uric acid in human serum.
BIOELECTROCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Charlotte Da Silva, Camille Lamarche, Carole Pichereaux, Emmanuelle Mouton-Barbosa, Gauthier Demol, Sebastien Boisne, Etienne Dague, Odile Burlet-Schiltz, Flavien Pillet, Marie-Pierre Rols
Summary: Low-energy electron beams (LEEB) are a safe and practical sterilization solution for industrial applications. To address the limitations of LEEB, we developed a low-energy pulsed electron beam generator (LEPEB) that can effectively and efficiently eradicate bacteria in a wide range of industrial applications.
BIOELECTROCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Daniel Dobrovodsky, Ales Danhel, Daniel Renciuk, Jean-Louis Mergny, Miroslav Fojta
Summary: In this study, N-methyl mesoporphyrin IX (NMM) was utilized as a voltammetric probe for the electrochemical detection of G4s. The detection of NMM was achieved by cyclic voltammetry on a hanging mercury drop electrode (HMDE) with a limit of detection (LOD) of 40 nM. The reduction signal of NMM was found to be significantly higher when G4 oligodeoxynucleotides (G4 ODNs) were present compared to single- or double-stranded ODNs or unfolded ODNs capable of forming G4s. Gradual transition from unstructured single strand to G4, induced by increasing concentrations of the G4 stabilizing K+ ions, was detected for the first time using electrochemical methods. Circular dichroism spectroscopy provided support for the obtained results. This work expands on the utilization of electrochemical probes for DNA secondary structure recognition and offers a proof of principle for the development of novel electroanalytical methods for nucleic acid structure studies.
BIOELECTROCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Mengjiao Zhu, Yu Liu, Meiyue Wang, Tao Liu, Zhenyu Chu, Wanqin Jin
Summary: Early rapid diagnosis of COVID-19 is crucial for reducing the risk of severe symptoms and loss of lung function. Researchers have proposed an ultrafast and ultrasensitive DNA sensor that can accurately detect the virus in a short period of time, with outstanding selectivity.
BIOELECTROCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Fatima-Zahra Ait-Itto, James A. Behan, Mathieu Martinez, Frederic Barriere
Summary: This study investigated the feasibility of using ancient marine sediments as inoculum for bioanode development in microbial fuel cells (MFC). The results showed the presence of two exoelectrogenic bacterial genera in these iron-rich sediments and confirmed that the development of the bioanode derived from the native microbiota. This study has important implications for understanding the role of these bacteria in broader paleoenvironmental phenomena.
BIOELECTROCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Issa Fall, Bastien Doumeche, Sofiene Abdellaoui, Caroline Remond, Harivony Rakotoarivonina, Marjorie Ochs
Summary: This article presents a novel electrochemical tool based on lignin-coated paper electrodes for the detection and characterization of ligninolytic activity. The suitability of this method has been demonstrated using a catalaseperoxidase isolated from Thermobacillus xylanilyticus.
BIOELECTROCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Chenyi Zhuo, Dehong Yu, Jiuying Cui, Zichun Song, Qianli Tang, Xianjiu Liao, Zhao Liu, Ning Xin, Lu Lou, Fenglei Gao
Summary: A label-free detection strategy for quantification of Apolipoprotein A4 (Apo-A4) has been developed based on rolling circle amplification (RCA) and proximity hybridization-induced DNAzyme-driven bipedal DNA walker. This method shows high sensitivity and selectivity for a wide range of protein targets.
BIOELECTROCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Niloufar Fattahi, Jeffrey Reed, Evan Heronemus, Priyasha Fernando, Ryan Hansen, Prathap Parameswaran
Summary: In this study, polyethylene glycol hydrogels were developed as protective coatings for electroactive biofilms, improving their viability under low resource conditions and ammonia-N shocks.
BIOELECTROCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Xiaopeng Hou, Qiongyi Cheng, Hui Wang
Summary: A self-cleaning paper-based microfluidic biosensor was developed using hydrophobic paper decorated with polymeric octadecyl trichlorosilane. The biosensor showed improved performance and could effectively measure the concentration of copper ions in livestock feed and manure.
BIOELECTROCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Yanling Zhang, Jie Wang, Min Liu, Yun Ni, Yao Yue, Dawei He, Ruijiang Liu
Summary: An innovative electrochemical biosensor has been developed for sensitive detection of HER2 protein, an important tumor marker for breast cancer diagnosis and treatment evaluation. The biosensor utilizes specific recognition probes and nanomaterials, along with a unique sensing strategy, to achieve ultra-low detection limit and demonstrate excellent selectivity, reproducibility, and stability.
BIOELECTROCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Humayun Amir, Vasanth Subramanian, Sundaram Sornambikai, Nagamony Ponpandian, Chinnusamy Viswanathan
Summary: In this study, the electrochemical detection of breast cancer biomarker HER2 was successfully achieved using the N-CQDs/GS as the detector. The BSA-modified HER2 Antibody/N-CQDs/GS immunoelectrode preserved excellent activity for the biosensor, while the GS electrode provided high stability and conductivity. The method exhibited a low detection limit and optimal specificity, stability, and reproducibility for detecting HER-2 protein in untreated blood samples from breast cancer patients.
BIOELECTROCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Ilona Uzieliene, Anton Popov, Raminta Vaiciuleviciute, Gailute Kirdaite, Eiva Bernotiene, Almira Ramanaviciene
Summary: This review discusses the application of polypyrrole (Ppy), an electroconductive polymer, in cell culture experiments with electrical stimulation (ES) and its potential for tissue regeneration. Ppy can direct ES to cells and stimulate differentiation towards different cell lineages. Different types of Ppy materials and their combination with active molecules are explored.
BIOELECTROCHEMISTRY
(2024)
