CD6 as a Therapeutic Target in Autoimmune Diseases: Successes and Challenges

Protein Interactions between CD2 and Lck Are Required for the Lipid Raft Distribution of CD2

(2014) R. J. Nunes et al.   JOURNAL OF IMMUNOLOGY

Self-reactive human CD4 T cell clones form unusual immunological synapses

(2012) David A. Schubert et al.   JOURNAL OF EXPERIMENTAL MEDICINE

T Cell Apoptosis and Induction of Foxp3+ Regulatory T Cells Underlie the Therapeutic Efficacy of CD4 Blockade in Experimental Autoimmune Encephalomyelitis

(2012) J. Duarte et al.   JOURNAL OF IMMUNOLOGY

CD6 and Syntaxin Binding Protein 6 Variants and Response to Tumor Necrosis Factor Alpha Inhibitors in Danish Patients with Rheumatoid Arthritis

(2012) Sophine B. Krintel et al.   PLoS One

CD6 attenuates early and late signaling events, setting thresholds for T-cell activation

(2011) Marta I. Oliveira et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Effector T cells in rheumatoid arthritis: Lessons from animal models

(2011) Saba Alzabin et al.   FEBS LETTERS

A New Pathway of CD5 Glycoprotein-mediated T Cell Inhibition Dependent on Inhibitory Phosphorylation of Fyn Kinase

(2011) Martina Bamberger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The CD6 Multiple Sclerosis Susceptibility Allele Is Associated with Alterations in CD4+ T Cell Proliferation

(2011) D. M. Kofler et al.   JOURNAL OF IMMUNOLOGY

6thAnnual European Antibody Congress 2010

(2011) Alain Beck et al.   mAbs

Antibody-based therapeutics to watch in 2011

(2011) Janice M. Reichert   mAbs

CD6 synergistic co-stimulation promoting proinflammatory response is modulated without interfering with the activated leucocyte cell adhesion molecule interaction

(2010) P. Nair et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Aberrant expression of CD6 on B-cell subsets from patients with Sjögren’s syndrome

(2010) Ruby Alonso et al.   JOURNAL OF AUTOIMMUNITY

Validation of the CD6 and TNFRSF1A loci as risk factors for multiple sclerosis in Spain

(2010) Bhairavi Swaminathan et al.   JOURNAL OF NEUROIMMUNOLOGY

Multiple sclerosis susceptibility alleles in African Americans

(2009) B A Johnson et al.   GENES AND IMMUNITY

Genome-wide analysis of allelic expression imbalance in human primary cells by high-throughput transcriptome resequencing

(2009) Graham A. Heap et al.   HUMAN MOLECULAR GENETICS

Characteristics of the minor salivary gland infiltrates in Sjögren's syndrome

(2009) Maria I. Christodoulou et al.   JOURNAL OF AUTOIMMUNITY

Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci

(2009) Philip L De Jager et al.   NATURE GENETICS

Towards the Definition of a Chimpanzee and Human Conserved CD6 Domain 1 Epitope Recognized by T1 Monoclonal Antibody

(2008) Ruby Alonso et al.   HYBRIDOMA

Long-term outcomes of nonconditioned patients with severe combined immunodeficiency transplanted with HLA-identical or haploidentical bone marrow depleted of T cells with anti-CD6 mAb

(2008) Niraj C. Patel et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY