Therapeutic Potential of Aptamer-siRNA Conjugates for Treatment of HIV-1

Inhibition of HIV transmission in human cervicovaginal explants and humanized mice using CD4 aptamer-siRNA chimeras

(2011) Lee Adam Wheeler et al.   JOURNAL OF CLINICAL INVESTIGATION

Current prospects for RNA interference-based therapies

(2011) Beverly L. Davidson et al.   NATURE REVIEWS GENETICS

Barriers to Non-Viral Vector-Mediated Gene Delivery in the Nervous System

(2011) Francisco C. Pérez-Martínez et al.   PHARMACEUTICAL RESEARCH

The utility of the new generation of humanized mice to study HIV-1 infection: transmission, prevention, pathogenesis, and treatment

(2011) Bradford K Berges et al.   Retrovirology

An Aptamer-siRNA Chimera Suppresses HIV-1 Viral Loads and Protects from Helper CD4+ T Cell Decline in Humanized Mice

(2011) C. P. Neff et al.   Science Translational Medicine

Molecular aptamers for drug delivery

(2011) Weihong Tan et al.   TRENDS IN BIOTECHNOLOGY

Delivery of siRNA Therapeutics: Barriers and Carriers

(2010) Jie Wang et al.   AAPS Journal

Aptamers as therapeutics

(2010) Anthony D. Keefe et al.   NATURE REVIEWS DRUG DISCOVERY

Advances in Aptamers

(2010) Muhammad Ali Syed et al.   OLIGONUCLEOTIDES

Cell-Specific Aptamer-Mediated Targeted Drug Delivery

(2010) Jiehua Zhou et al.   OLIGONUCLEOTIDES

Anticipating and blocking HIV-1 escape by second generation antiviral shRNAs

(2010) Nick CT Schopman et al.   Retrovirology

RNA-Based Gene Therapy for HIV with Lentiviral Vector-Modified CD34+ Cells in Patients Undergoing Transplantation for AIDS-Related Lymphoma

(2010) D. L. DiGiusto et al.   Science Translational Medicine

Aptamers Generated from Cell-SELEX for Molecular Medicine: A Chemical Biology Approach

(2009) Xiaohong Fang et al.   ACCOUNTS OF CHEMICAL RESEARCH

The Chemical Biology of Aptamers

(2009) Günter Mayer   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Progress towards Therapeutic Application of RNA Interference for HIV Infection

(2009) Sunit K. Singh et al.   BIODRUGS

A Genome-wide Short Hairpin RNA Screening of Jurkat T-cells for Human Proteins Contributing to Productive HIV-1 Replication

(2009) Man Lung Yeung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The promises and pitfalls of RNA-interference-based therapeutics

(2009) Daniela Castanotto et al.   NATURE

Systemic administration of optimized aptamer-siRNA chimeras promotes regression of PSMA-expressing tumors

(2009) Justin P Dassie et al.   NATURE BIOTECHNOLOGY

Knocking down barriers: advances in siRNA delivery

(2009) Kathryn A. Whitehead et al.   NATURE REVIEWS DRUG DISCOVERY

Selection, characterization and application of new RNA HIV gp 120 aptamers for facile delivery of Dicer substrate siRNAs into HIV infected cells

(2009) Jiehua Zhou et al.   NUCLEIC ACIDS RESEARCH

The Challenge of Finding a Cure for HIV Infection

(2009) D. D. Richman et al.   SCIENCE

Global Analysis of Host-Pathogen Interactions that Regulate Early-Stage HIV-1 Replication

(2008) Renate König et al.   CELL

Knockdown Screens to Knockout HIV-1

(2008) Stephen P. Goff   CELL

Genome-Scale RNAi Screen for Host Factors Required for HIV Replication

(2008) Honglin Zhou et al.   Cell Host & Microbe

CELL-SELEX: Novel Perspectives of Aptamer-Based Therapeutics

(2008) Ke-Tai Guo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Novel Dual Inhibitory Function Aptamer–siRNA Delivery System for HIV-1 Therapy

(2008) Jiehua Zhou et al.   MOLECULAR THERAPY

Lentiviral Vector Design for Multiple shRNA Expression and Durable HIV-1 Inhibition

(2008) Olivier ter Brake et al.   MOLECULAR THERAPY

Mechanisms and strategies for effective delivery of antisense and siRNA oligonucleotides

(2008) R. Juliano et al.   NUCLEIC ACIDS RESEARCH

Identification of Host Proteins Required for HIV Infection Through a Functional Genomic Screen

(2008) Abraham L. Brass et al.   SCIENCE

An aptamer that neutralizes R5 strains of HIV-1 binds to core residues of gp120 in the CCR5 binding site

(2008) Carla Cohen et al.   VIROLOGY