Article
Spectroscopy
Jin Bai, Lei Zhang, Ying Qian
Summary: In this study, a novel NIR and lysosomal targeting thiophene-BODIPY photosensitizer SBOP-Lyso was synthesized to explore its potential applications in photodynamic therapy. SBOP-Lyso demonstrated high singlet oxygen yield, good biocompatibility, and effective inhibition of A549 cells migration. The unique lysosome-targeted properties of SBOP-Lyso make it a promising candidate for cancer cell PDT.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Chemistry, Applied
Dmytro Kobzev, Olga Semenova, Anatoliy Tatarets, Andrii Bazylevich, Gary Gellerman, Leonid Patsenker
Summary: Photoimmunotherapy (PIT) is a cancer treatment that combines immunotherapy and photodynamic treatment (PDT). In this study, a cyanine dye - antibody PIT conjugate was developed and studied for the first time. Results showed that the 2ICy7-Ab conjugate suppressed tumor growth four-fold more efficiently than the Cy7-Ab conjugate, while the immunotherapeutic effect resulted only in 1.4-fold suppression.
Article
Chemistry, Multidisciplinary
Guangzhao Lu, Xiqing Gao, He Zhang, Yeye Zhang, Yuan Yu, Zhiguo Sun, Wei Li, Wei Wu, Ying Lu, Hao Zou
Summary: This study aims to develop a novel near-infrared light-responsive carrier for the local release of antitumor drugs. The research utilizes a photosensitizer to generate singlet oxygen, which oxidizes unsaturated phospholipids and leads to drug release. The near-infrared light-responsive carrier demonstrates enhanced anticancer activity through a combination of photodynamic therapy and chemotherapy.
CHINESE CHEMICAL LETTERS
(2022)
Review
Chemistry, Inorganic & Nuclear
E. Pang, Shaojing Zhao, Benhua Wang, Guangle Niu, Xiangzhi Song, Minhuan Lan
Summary: This article systematically summarizes various strategies to improve the generation efficiency of singlet oxygen (O-1(2)) in photosensitizers (PS) and discusses their advantages, disadvantages, and challenges.
COORDINATION CHEMISTRY REVIEWS
(2022)
Article
Chemistry, Physical
Fangyu Jin, Shiqin Liao, Qingqing Wang, Huiying Shen, Chenyu Jiang, Jiawen Zhang, Qufu Wei, Reza A. Ghiladi
Summary: In this study, a scalable and facile method to immobilize long persistent phosphor and photosensitizer onto cotton fabric was reported. The resulting composite material exhibited superior antibacterial activity against Staphylococcus aureus and methicillin-resistant S. aureus under visible-light illumination. Mechanistic studies showed enhanced singlet oxygen production, resulting in effective pathogen inactivation. In addition, the composite fabric possessed excellent abrasion resistance, mechanical strength, and color fastness. These findings suggest the potential of using long persistent phosphors in composite fabrics for infection control applications.
APPLIED SURFACE SCIENCE
(2022)
Article
Chemistry, Applied
Pinar Sen, Rodah Soy, Sithi Mgidlana, John Mack, Tebello Nyokong
Summary: The emergence of antimicrobial resistance has made the development of photodynamic therapy (PDT) related applications essential, since microorganisms cannot develop resistance to this method. This study focuses on the synthesis, characterization, and evaluation of the utility of palladium porphyrins and their chitosan inclusion complexes as photosensitizer dye in photodynamic antimicrobial therapy (PACT). The photophysical-chemical studies showed that the immobilization of the porphyrins into the chitosan influenced their properties. Furthermore, the PACT activity of cationic porphyrin and its chitosan immobilization form were found to be effective in decreasing the number of viable cells up to 100% in vitro.
Review
Biochemistry & Molecular Biology
Shang Jia, Ellen M. Sletten
Summary: This Review highlights recent developments in synthetic far-red and near-infrared photocages and photoswitches and their current and potential applications at the interface of chemistry and biology.
ACS CHEMICAL BIOLOGY
(2022)
Article
Chemistry, Applied
Loveleen Kaur Gulati, Gurleen Kaur Gulati, Satish Kumar
Summary: This article discusses the use of photochromism in photodynamic therapy, highlighting the potential of photochromic substances in three different roles to enhance efficacy: as photosensitizers, switches to conventional photosensitizers, and reserves of singlet oxygen.
Article
Chemistry, Physical
Li Yang, Bin Huang, Shiqi Hu, Yuan An, Jingyi Sheng, Yan Li, Yuxin Wang, Ning Gu
Summary: This study successfully improved the photodynamic therapy (PDT) efficacy of indocyanine green (ICG) by assembling free ICG molecules with free oxygen nanobubbles (NBs-O-2), and evaluated its therapeutic efficacy in the treatment of oral cancer in vivo. The results demonstrated that ICG-NBs-O-2 showed excellent tumor ablation and has great potential for clinical application.
Article
Chemistry, Multidisciplinary
Wentao Wang, Fan Wu, Qicheng Zhang, Ninglin Zhou, Ming Zhang, Tao Zheng, Yuanyuan Li, Ben Zhong Tang
Summary: By synthesizing quaternary amine functionalized aggregation-induced emission (AIE) materials to produce singlet oxygen and heat, the nanoparticles selectively targeted Gram-positive and Gram-negative bacteria, exhibiting significant antibacterial performance.
Article
Biochemistry & Molecular Biology
Alexander M. Firsov, Juergen Pfeffermann, Anton S. Benditkis, Tatyana I. Rokitskaya, Anton S. Kozlov, Elena A. Kotova, Alexander A. Krasnovsky, Peter Pohl, Yuri N. Antonenko
Summary: The goal of developing chemical compounds that can mimic the functions of biological molecular machineries has resulted in the creation of various artificial molecular motors (AMMs). These photoexcited monomolecular unidirectionally-rotating AMMs have been seen as potentially useful in pharmaceutical applications due to their ability to permeabilize biological membranes. However, the mechanical properties of lipid membranes cast doubt on the proposed drilling activity of AMMs. In this study, it was discovered that singlet oxygen released by a photoexcited molecular drill could oxidize unsaturated lipids in giant unilamellar vesicles, while liposomes made of saturated lipids remained unaffected. Further experiments showed that rather than mechanically destroying ion channels in lipid membranes, the AMMs photoinactivated them. This study suggests that the envisioned therapeutic and pharmaceutical applications of AMMs rely more on their photodynamic activity than their nanomechanical drilling abilities.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2023)
Article
Environmental Sciences
Xiaojie Xu, Min Yang, Yunhan Jiang, Ningyao Tao, Yulong Fu, Jiahui Fan, Xin Xu, Huixiang Shi, Zhan Lu, Chaofeng Shen
Summary: The spread of antibiotic resistant pathogens and antibiotic resistance genes in the environment is a serious threat to public health. Existing methods are ineffective in removing them, but a new acridine-based photosensitizer called YM-3 has been developed in this study, which can effectively inactivate antibiotic resistant pathogens and reduce antibiotic resistance genes by generating singlet oxygen. YM-3 has shown a high inactivation rate for methicillin-resistant Staphylococcus aureus and carbapenem-resistant Acinetobacter baumannii, and it can effectively reduce the copy numbers of antibiotic resistance genes in these bacteria. It also has a long-lasting bactericidal effect, making it suitable for disinfection in various environments.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Chemistry, Multidisciplinary
Qiang Liu, Jiangwei Tian, Ye Tian, Qinchao Sun, Dan Sun, Feifei Wang, Haijun Xu, Guoliang Ying, Jigang Wang, Ali K. Yetisen, Nan Jiang
Summary: The study developed BODIPY-I-N-anti-PD-L1 nanoparticles with high singlet oxygen quantum yield for photodynamic/immune combination therapy and tumor prevention in the NIR-II window. The targeted nanoparticles showed efficient elimination of primary cancers and durable immune memory effect against tumor rechallenging without toxic side effects.
Article
Chemistry, Applied
Ruth Prieto-Montero, Alejandro Prieto-Castaneda, Alberto Katsumiti, Rebeca Sola-Llano, Antonia R. Agarrabeitia, Miren P. Cajaraville, Maria J. Ortiz, Virginia Martinez-Martinez
Summary: Three different molecular designs based on BODIPY dye have been proposed as photosensitizers for photodynamic therapy, showing a good balance between singlet oxygen generation and fluorescence for potential applications. In vitro experiments in HeLa cells were conducted to elucidate the best potential candidate for PDT.
Article
Biochemistry & Molecular Biology
Zhu-Ying Yan, Jing Chen, Jie Shao, Ze-Qing Jiao, Tian-Shu Tang, Miao Tang, Zhi-Guo Sheng, Li Mao, Rong Huang, Chun-Hua Huang, Zhi-Hui Zhang, Hong-Mei Su, Ben-Zhan Zhu
Summary: The study identified a novel cell-impermeable Ru(II) polypyridyl cationic complex that generates high phototoxicity under visible light irradiation while demonstrating low dark toxicity, showing potential for applications in photodynamic therapy.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Review
Nanoscience & Nanotechnology
Youliang Tian, Dalong Yin, Lifeng Yan
Summary: This article discusses the J-aggregation of organic dyes and their applications in near-infrared imaging and phototherapy. J-aggregates exhibit unique physical properties, such as enhanced absorption, narrowed spectral bandwidth, and aggregation-induced emission enhancement, which offer great potential for biological applications. However, the rational design of molecular structures to achieve J-aggregation of organic dyes remains a challenging task.
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2023)
Article
Chemistry, Applied
Hua Wang, Xing Guo, Weibin Bu, Zhengxin Kang, Changjiang Yu, Qinghua Wu, Lijuan Jiao, Erhong Hao
Summary: A series of boronic acid derived salicylidenehydrazinopyridine complexes were synthesized and characterized. These complexes display a tetrahedral geometry due to the boron atoms and exhibit stereochemistry and molecular chirality. The curved nonplanar structure and axial-substituted groups of the complexes provide solubility and steric protection. The complexes also show strong absorption, weak emission, and large Stoke shifts, as well as aggregation-induced emission activities, making them potential bioimaging dyes.
Article
Chemistry, Multidisciplinary
Jun Wang, Huiquan Zuo, Qinghua Wu, Erhong Hao, Lijuan Jiao
Summary: In this study, two novel phenylenes bridged dimeric BOBPY were designed and synthesized. The resulting dyes showed high photostability, intense absorption and emission properties, and the electronic interactions were related to the length of the linker.
JOURNAL OF PORPHYRINS AND PHTHALOCYANINES
(2023)
Article
Chemistry, Organic
Zhaoyun Wang, Xing Guo, Zhengxin Kang, Qinghua Wu, Heng Li, Cheng Cheng, Changjiang Yu, Lijuan Jiao, Erhong Hao
Summary: An efficient procedure is developed for synthesizing aryl-boron-substituted BODIPY and aza-BODIPY derivatives through functional-nucleophiles in the presence of aluminum chloride. These derivatives exhibit bright emission in aqueous solution, with enhanced aggregation-induced emission and high solid-state emission due to restricted rotation and the formation of J-type aggregates.
Article
Spectroscopy
Wanle Sheng, Xing Guo, Bing Tang, Weibin Bu, Fan Zhang, Erhong Hao, Lijuan Jiao
Summary: The optical properties and aggregation-induced emission (AIE) activities of BODIPYs with TPA groups were studied systematically, and the dynamic behaviors of lipid droplets and lysosomes in living cells were successfully tracked through organelle-specific imaging.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Chemistry, Physical
Sai Yang, Xiaodong Hou, Zhiwei Deng, Lifeng Yang, Qian Ping, Zhenbo Yuan, Yan Zhang, Yijian Rao
Summary: In this study, a thermostable YojKM1 mutant was successfully developed for the potential industrial production of Reb D. The mutant exhibited a significantly increased halftime at 50 degrees C and improved catalytic activity. Structural analysis revealed that the enhanced thermostability of YojKM1 was attributed to the formation of new hydrogen bond interactions, salt bridges, and optimization of surface electrostatic charges. A fed-batch reaction using the mutant resulted in a high yield of Reb D at 50 degrees C.
MOLECULAR CATALYSIS
(2023)
Article
Biochemistry & Molecular Biology
Shangzhong Zhang, Yi Duan, Changchang Teng, Hongdong Quan, Xiuguo Yang, Hongyan Li, Xiaohe Li, Lifeng Yan
Summary: The conversion of lignocellulose into valuable chemicals is a key technology in green chemistry. A two-step process has been developed to degrade corncob into xylose and glucose under mild conditions. The total yield of xylose is 97% and glucose is 95%. Additionally, high-quality cellulose and lignin can be obtained.
Article
Chemistry, Organic
Changjiang Yu, Yingzhu Sun, Lijuan Jiao, Erhong Hao
Summary: In recent years, several series of novel diboron compounds with tunable structures and outstanding spectroscopic properties have been developed as valuable fluorophores. This article mainly focuses on the synthetic strategies and superior properties of the fluorophores BOPHY, BOPPY, and BOAPY developed by our group. It also includes significant photophysical data of these fluorophores in solution and solid states. The facile functionalization of these fluorophores allows for practical structural modifications to generate versatile dyes with excellent chemical and photophysical properties. We believe that these fluorophores have the potential to make important contributions in a wide range of applications.
Review
Chemistry, Inorganic & Nuclear
Zhongxin Li, Qingbao Gong, Erhong Hao, Lijuan Jiao
Summary: In recent years, subporphyrazines and subporphyrins, fascinating ring-contracted porphyrinoids containing boron, have been developed as promising functional dyes due to their interesting structural, photophysical and electrochemical properties. This review provides an overview of their synthesis and summarizes the main structural modification methods, as well as discusses related analogues, dimers and oligomers, and stable subporphyrin radicals. Special attention is given to outstanding free base triphyrin(1.1.1) and free base subporphyrin, as well as hybrid subporphyrinoids.
COORDINATION CHEMISTRY REVIEWS
(2023)
Article
Chemistry, Applied
Xiangmin Wang, Xiaofan Fu, Weibin Bu, Changjian Yu, Erhong Hao, Lijuan Jiao, Qinghua Wu, Rentian Wang, Jinjun Wang, Jiazhu Li
Summary: Fusion of thiophene to BODIPY allows for the development of novel symmetric bisbenzothieno[b]-fused BODIPYs (BTBs) with absorption maxima in the range of 643-665 nm, large molar extinction coefficients, and high singlet oxygen generation. Theoretical calculations show that the smaller singlet-triplet energy gap and larger spin-orbit coupling contribute to efficient intersystem crossing and increased singlet oxygen generation yield. Interestingly, a methyl diphenyl substituted BTB exhibits good reactive oxygen species generation efficiency (0.41) and remarkable photo-cytotoxicity (IC50 = 83.5 nM) in HeLa cells, demonstrating its potential in low-dose photodynamic therapy.
Article
Chemistry, Physical
Juan Wu, Yongqi Deng, Yihan Wu, Lifeng Yan
Summary: In this study, reduced graphene oxide/poly(3,4-ethylenedioxythiophene):poly(sodium styrene sulfonate) composite (rGO/PEDOT:PSS) was prepared through a facile hydrothermal reaction and applied to a symmetric supercapacitor. The optimized composite showed improved electrochemical performance with a specific capacitance 50% higher than pure rGO. It also exhibited excellent photothermal properties with a high photothermal conversion efficiency of 62.0% under 808 nm NIR light illumination. The photothermal effect enhanced the supercapacitor's performance, increasing its specific capacitance and energy density by 1.8 and 1.6 times, respectively, under a low illumination intensity of 0.18 W cm-2. This study provides new design ideas for next-generation flexible and wearable devices and expands the application of light energy.
JOURNAL OF ALLOYS AND COMPOUNDS
(2023)
Article
Chemistry, Multidisciplinary
Yongqi Deng, Hongfei Wang, Minghui Fan, Boxiang Zhan, Lu-Jie Zuo, Cheng Chen, Lifeng Yan
Summary: A novel nanomicellar electrolyte using methylurea (Mu) has been developed to guide the homogeneous deposition of Zn2+ / Mn2+ and inhibit water-splitting-derived side reactions. The modified electrolyte also enhances the reversibility of the Mn2+ / MnO2 conversion reaction by regulating interfacial wettability and improving nucleation kinetics. These improvements result in extended cyclic stability, suppressed dendrites growth, exceptional capacity retention, and a high energy density in Zn-Mn batteries.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Analytical
Yixuan Xu, Changchang Teng, Huiping Dang, Dalong Yin, Lifeng Yan
Summary: Stable organic radical molecules with high NIR fluorescence quantum efficiency have been synthesized and encapsulated into nanoparticles, which show great potential for both photodynamic therapy (PDT) and photothermal therapy (PTT) of tumors.
Article
Chemistry, Physical
Yongqi Deng, Yihan Wu, Kefu Zhang, Minghui Fan, Lele Wang, Yapeng He, Lifeng Yan
Summary: A low-cost eutectic electrolyte composed of acetate and urea is reported, expanding the electrochemical stability window to >3.5 V with minimal water content and non-flammability. The water-starved solvation structure protects the zinc anode from dendrite growth and reduces parasitic side reactions, while the wide electrochemical window enables high operating voltage for zinc-based batteries. The optimized eutectogel inherits the advantages of liquid eutectic electrolytes while also providing excellent mechanical properties for flexible batteries under deformation conditions. The eutectic electrolyte has potential applications in high-voltage aqueous zinc ion batteries, combining performance, low cost, safety, and sustainability.
JOURNAL OF MATERIALS CHEMISTRY A
(2023)
Article
Chemistry, Multidisciplinary
Boxiang Zhan, Long Zhang, Yongqi Deng, Lifeng Yan
Summary: A preparation method for a lignin-based composite adhesive was presented in this paper. The adhesive showed excellent performance, including high adhesive strength, good flame retardance, and outstanding thermal insulation and photothermal properties. It can also be used to process wood chips into regenerated wood.
