期刊
JOURNAL OF BIOPHOTONICS
卷 9, 期 4, 页码 364-375出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/jbio.201500006
关键词
tissue polarimetry; optical diagnosis; Mueller matrix; digital staining; polarimetry imaging
资金
- NMRC NIG grant [NMRC/NIG 1048/2011]
- MoE in Singapore [RG38/14]
Digital staining based on Mueller matrix measurements and their derivatives was investigated. Mueller matrix imaging was performed at the microscopic level on gastric tissue sections. Full Mueller matrices (4 x 4) were reconstructed using recorded images, followed by the extraction of polarization parameters. The most effective parameters and their combinations were extracted from Mueller matrix elements, principal component scores and polarization parameters respectively to classify samples into three categories -i.e. cancer, dysplasia and intestinal metaplasia/normal glands for various regions of interest sizes. It was observed that two-step classification yielded higher classification accuracy than the traditional one-step classification and that pixel classification based on Mueller matrix elements yielded higher accuracy than that based on polarization parameters and derived principal components. Moreover, Mueller matrix images with a lower spatial resolution generated higher classification accuracy but those with a higher spatial resolution revealed more morphological details.ns. [GRAPHICS] The original stained image (top) and the digital staining image (bottom).
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