Article
Chemistry, Multidisciplinary
Hyun Lee, Dongwhan Lee
Summary: This Concept article discusses the precise spatial control over assembly patterns using molecular clips, which enable the construction of multi-layer pi-stacks and long-range spatial ordering through various design strategies and the choice of spine units.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Physical
Sergiy Perepelytsya, Tudor Vasiliu, Aatto Laaksonen, Leon De Villiers Engelbrecht, Giuseppe Brancato, Francesca Mocci
Summary: Natural polyamines, particularly spermidine, are crucial for stabilizing DNA double helix structure in the cell nucleus. In this study, molecular dynamics simulations reveal the conformational space of spermidine3+ in solution and its interaction with DNA. The results provide insight into the equilibrium and dynamics of spermidine3+ and its importance in DNA interaction.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Multidisciplinary Sciences
Eliza S. Nieweglowska, Axel F. Brilot, Melissa Mendez-Moran, Claire Kokontis, Minkyung Baek, Junrui Li, Yifan Cheng, David Baker, Joseph Bondy-Denomy, David A. Agard
Summary: To protect themselves from host attack, jumbo bacteriophages form a micron-scale protein structure to contain their replicating DNA. CryoEM analysis reveals that this structure is an assembly of tetramers linked by flexible loops and tails.
NATURE COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Lorenzo Rovigatti, John Russo, Flavio Romano, Michael Matthies, Lukas Kroc, Petr Sulc
Summary: In this study, we address the problems faced during the self-assembly of colloidal diamond crystals by using the SAT-assembly design framework. We demonstrate that the assembly of CD crystals only requires a binary mixture, and we test a promising DNA nanotechnology design using molecular dynamics simulations.
Article
Chemistry, Multidisciplinary
Jinhua Wang, Barbara Wicher, Alejandro Mendez-Ardoy, Xuesong Li, Gilles Pecastaings, Thierry Buffeteau, Dario M. Bassani, Victor Maurizot, Ivan Huc
Summary: 8-amino-2-quinolinecarboxylic acid oligoamides can uptake Cu-II ions through deprotonation of their amide functions, forming intramolecular linear arrays of Cu-II centers. The metal-loaded helices allow for electron transport, in contrast to hole transport observed in similar foldamers without metal ions.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Karol Woloszyn, Simon Vecchioni, Yoel P. Ohayon, Brandon Lu, Yinglun Ma, Qiuyan Huang, Eric Zhu, Daniel Chernovolenko, Tiffany Markus, Natasa Jonoska, Chengde Mao, Nadrian C. Seeman, Ruojie Sha
Summary: This study expands the library of accessible motifs in DNA tensegrity triangle through sticky-end cohesion and covalent extensions, achieving fine control and customizability of 3D DNA lattices. The designed DNA structures can be used for the self-assembly of nanocages, guest-host complexes, and 3D nanomaterials.
ADVANCED MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Rebecca K. Lau, Eray Enustun, Yajie Gu, Justin Nguyen, Kevin D. Corbett
Summary: Bacteria have evolved diverse immune systems to protect themselves from phage infection. Researchers have discovered a transcriptional regulator module associated with hundreds of CBASS immune systems and demonstrated its role in driving the expression of the CBASS system in response to DNA damage. This finding highlights a mechanism by which bacterial immune systems can sense and respond to cellular stress.
Article
Biochemistry & Molecular Biology
Valentin Quebre, Irene del Campo, Ana Cuevas, Patricia Siguier, Jerome Rech, Phan Thai Nguyen Le, Bao Ton-Hoang, Francois Cornet, Jean-Yves Bouet, Gabriel Moncalian, Fernando de la Cruz, Catherine Guynet
Summary: This study determined the crystal structure of the conserved N-terminal domain of StbA, revealing the molecular basis of StbA and its role in plasmid segregation.
JOURNAL OF MOLECULAR BIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
M. F. Di Filippo, D. Giuri, G. Marchiori, M. Maglio, S. Pagani, M. Fini, C. Tomasini, S. Panzavolta
Summary: Calcium phosphate cements have the potential to mimic native bone and provide stability in bone defects and implant sites. Incorporating fibers into the cement matrix increases its mechanical properties. The formation of self-assembling fibers during cement setting improves cohesion and mechanical reinforcement.
MATERIALS TODAY CHEMISTRY
(2022)
Article
Chemistry, Physical
Zhen Liu, Xinjie Shi, Wenchao Shu, Shuo Qi, Xiaosong Wang, Xiaohua He
Summary: Hydration and dehydration have significant effects on the conformation and self-assembly behavior of poly(gamma-benzyl-l-glutamate) (PBLG) homopolymers, resulting in variations in optical properties. This finding is crucial for the innovation of polypeptide materials and understanding water-mediated biological systems.
Article
Chemistry, Multidisciplinary
Xia Li, Jialin Xie, Zhenglin Du, Long Jiang, Guangqin Li, Sanliang Ling, Kelong Zhu
Summary: A zirconium metal-organic framework with a T-shaped benzimidazole strut was constructed and successfully used as a sponge-like material for selectively absorbing macrocyclic guests. The binding process was reversible and acid-base switchable. This study provides an alternative route for creating complex functional materials with interpenetrated structures.
Review
Chemistry, Multidisciplinary
Abhichart Krissanaprasit, Carson M. Key, Sahil Pontula, Thomas H. LaBean
Summary: Researchers have made progress in understanding and manipulating the rules of biomolecular design for artificial biopolymer complexes. Nucleic acid nanotechnology has advanced rapidly, with DNA and RNA design seeing amazing progress. By combining structural motifs with aptamers, nucleic acid-based self-assemblies offer bioengineers a diverse toolbox for potential revolutionary biological activities.
Article
Biochemistry & Molecular Biology
Diane M. Spencer, Angel Garza Reyna, David S. Pisetsky
Summary: DNA can have different backbone conformations, with Z-DNA being a left-handed helix with a zig-zag orientation depending on base sequence, modification, and supercoiling. Experimental results demonstrate that anti-Z-DNA antibodies can serve as probes for detecting the presence of Z-DNA in DNA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Nguyen Hoang Minh, Jae Sung Yoon, Do Hyun Kang, Yeong-Eun Yoo, Kwanoh Kim
Summary: Nanogap biosensors are promising platforms for detecting biochemical substances at low concentrations, but their fabrication processes and equipment can be arduous and costly. This research presents a novel design and fabrication process of vertical nanogap structures that can detect and quantify low-concentration biochemical substances. The nanogaps are created by magnetically assembling antibody-coated nanowires onto a nano-disk patterned between microelectrodes. The outcome of this research could inspire the design and fabrication of nanogap devices and nanobiosensors, with broad impacts on microfluidics, biochips, and lab-on-a-chip architectures.
Article
Chemistry, Multidisciplinary
Saikat Pahan, Sanjit Dey, Gijo George, Souvik Panda Mahapatra, DRGKoppalu R. Puneeth Kumar, Hosahudya. N. Gopi
Summary: In this study, chiral beta-double helices constructed from specific amino acids were observed in both single crystals and in solution. These structures can transport ions across membranes, suggesting their potential applications in designing functional foldamers.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Remy Pawlak, J. G. Vilhena, Philipp D'Astolfo, Xunshan Liu, Giacomo Prampolini, Tobias Meier, Thilo Glatzel, Justin A. Lemkul, Robert Haner, Silvio Decurtins, Alexis Baratoff, Ruben Perez, Shi-Xia Liu, Ernst Meyer
Article
Chemistry, Organic
Jovana Jevric, Simon M. Langenegger, Robert Haner
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2020)
Article
Chemistry, Organic
Giovanni Picca, Markus Probst, Simon M. Langenegger, Oleg Khorev, Peter Butikofer, Anant K. Menon, Robert Haner
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
(2020)
Article
Chemistry, Multidisciplinary
Remy Pawlak, Xunshan Liu, Silviya Ninova, Philipp D'Astolfo, Carl Drechsel, Sara Sangtarash, Robert Haner, Silvio Decurtins, Hatef Sadeghi, Colin J. Lambert, Ulrich Aschauer, Shi-Xia Liu, Ernst Meyer
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2020)
Article
Biochemical Research Methods
Simon Rothenbuehler, Ioan Iacovache, Simon M. Langenegger, Benoit Zuber, Robert Haener
Summary: The precise arrangement of structural subunits is crucial for the proper shape and function of supramolecular assemblies. In this study, chemically modified DNA hybrids were assembled into various architectures using an amphiphilic DNA duplex as the building block. The morphology of the assemblies was determined by the chemical nature of the subunit, such as the length of polyethylene glycols or the attachment of a carbohydrate moiety. Cryo-electron microscopy revealed the arrangement of the DNA duplexes within the different constructs, showing a change in morphology from vesicles to ribbons with increasing chain length of polyethylene glycol. Interestingly, the attachment of a N-acetylgalactosamine carbohydrate resulted in a novel star-shaped architecture. These findings provide new insights into the field of DNA nanotechnology.
BIOCONJUGATE CHEMISTRY
(2022)
Article
Chemistry, Organic
Jan Thiede, Simon Rothenbuhler, Ioan Iacovache, Simon M. Langenegger, Benoit Zuber, Robert Haner
Summary: This article presents the supramolecular self-assembly of pyrene-DNA conjugates into nanostructures. DNA functionalized with different types of pyrene isomers can self-assemble into nano-objects with various shapes. The research also constructs an artificial light-harvesting complex, which has implications for the design of photosynthetic devices.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Article
Chemistry, Organic
Simon Rothenbuehler, Adrian Gonzalez, Ioan Iacovache, Simon M. Langenegger, Benoit Zuber, Robert Haener
Summary: The supramolecular assembly of DNA conjugates with tetraphenylethylene (TPE) sticky ends into vesicular structures is studied in this research. The aggregation-induced emission (AIE) active TPE units are used to monitor the assembly process using fluorescence spectroscopy. The number of TPE modifications on the conjugates' overhangs influences the supramolecular assembly behavior, with a minimum of two TPE residues required for a well-defined assembly process. The designed DNA-based nanostructures offer customized functionalization for applications in DNA nanotechnology.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Jovana Jevric, Simon M. Langenegger, Robert Haener
Summary: This study describes the chemical synthesis and supramolecular assembly of an aromatic oligoamine, which leads to the formation of vesicular objects in aqueous solution. The assembly process is monitored by absorption and fluorescence spectroscopy, and the vesicles are characterized by atomic force and transmission electron microscopy. The electrostatic complementarity of anionic supramolecular polymer sheets and cationic vesicles is utilized for a layered assembly process.
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Larysa Markova, Markus Probst, Robert Haener
Article
Chemistry, Multidisciplinary
Ping Zhou, Ulrich Aschauer, Silvio Decurtins, Thomas Feurer, Robert Haner, Shi-Xia Liu
CHEMICAL COMMUNICATIONS
(2020)
Article
Chemistry, Multidisciplinary
Simon Rothenbuehler, Ioan Iacovache, Simon M. Langenegger, Benoit Zuber, Robert Haener
Article
Chemistry, Organic
Nutcha Burki, Elena Grossenbacher, Andrea Cannizzo, Thomas Feurer, Simon M. Langenegger, Robert Haner
ORGANIC & BIOMOLECULAR CHEMISTRY
(2020)
Article
Chemistry, Multidisciplinary
Peter W. Muenich, Matthias Pfaeffli, Michel Volland, Shi-Xia Liu, Robert Haener, Dirk M. Guldi