期刊
BIOCONJUGATE CHEMISTRY
卷 24, 期 6, 页码 1049-1056出版社
AMER CHEMICAL SOC
DOI: 10.1021/bc400115e
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资金
- National Natural Science Foundation of China [21074007, 51173014, 51221002]
- Research Fund for the Doctoral Program of Higher Education of China [20090010120007, 20120010110007]
- Program for New Century Excellent Talents in University [NCET-10-0203]
- SRF for ROCS, SEM
- National High Technology Development Program of China (863 Program) [2011AA030102]
A series of novel supramolecular pseudocomb polycations (l-PGEA-Ad/CD-PGEAs) were synthesized by tying multiple low-molecular-weight beta-cyclodextrin (CD)-cored, ethanolamine-functionalized poly(glycidyl methacrylate) (PGEA) star polymers (CD-PGEAs) with an adamantine-modified linear PGEA (l-PGEA-Ad) backbone via the host guest interaction. The pseudocomb carriers were studied in terms of their DNA binding capabilities, cytotoxicities, and gene transfection efficiencies in the HepG2 and HEK293 cell lines. The pseudocomb l-PGEA-Ad/CD-PGEAs exhibited better plasmid DNA-condensing abilities than their counterparts, CD-PGEA and l-PGEA. Meanwhile, the pseudocomb carriers displayed low cytotoxicity, similar to CD-PGEA and l-PGEA. Moreover, the gene transfection efficiencies of the pseudocomb carriers were much higher than those of CD-PGEA and l-PGEA at various PGEA nitrogen/DNA phosphate molar ratios. Such supramolecular preparation of pseudocomb gene carriers could provide a flexible approach for adjusting the structure and functionality of supramolecular polymers via the proper use of non-covalent interactions.
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