期刊
BIOCONJUGATE CHEMISTRY
卷 23, 期 5, 页码 1022-1028出版社
AMER CHEMICAL SOC
DOI: 10.1021/bc300012g
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资金
- Korea Ministry of Education, Science and Technology (MEST) [2011-0029930, 2011-0002139]
- National Research Foundation of Korea [2011-0002139] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
A novel iodinated chitosan-backboned conjugate (GC-I-Ce6) was designed and prepared to fabricate self-assembled biopolymeric nanoparticles with heavy atom-effected enhanced singlet oxygen generation as well as biological merits. The heavy atom-rich nature of the hydrophobic particle interior was characterized with X-ray absorption and the modified photophysical properties of a chemically embedded photosensitizer, chlorin e6 (Ce6). From the comparative spectroscopic studies as well as cellular and animal experiments, it has been shown that the self-assembled GC I Ce6 nanoparticles have enhanced capability of singlet oxygen generation by the intraparticle heavy-atom effect, along with high tumor targetability in vitro and in vivo thanks to the glycol chitosan-surfaced exterior with biocompatible, positively charged and tumor-homing characteristics. Actual efficacy improvement in the photodynamic therapy of a human breast cancer cell line (MDA-MB-231) demonstrates potential applications. of our photophysically and pharmaceutically motivated hybrid bioconjugate approach for nanomedicine applications.
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