Article
Biochemistry & Molecular Biology
Stephen Wan Leung, Po-Ching Cheng, Chih-Ming Chou, Chi Lin, Yu-Chieh Kuo, Yu-Lin Amy Lee, Cheng-Yang Liu, Fwu-Long Mi, Chia-Hsiung Cheng
Summary: This study demonstrated that low-molecular-weight chitosan could be utilized for gene delivery into zebrafish larvae, enhancing ISG expression, with potential implications for aquaculture applications. The delivery efficiency of LMWCSrNPs was highest at a weight ratio of 20:8:1.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Review
Polymer Science
Iyyakkannu Sivanesan, Shadma Tasneem, Nazim Hasan, Juhyun Shin, Manikandan Muthu, Judy Gopal, Jae-Wook Oh
Summary: Chitosan has made significant progress in biomedical applications, particularly in the field of drug delivery. Modified chitosan derivatives have overcome limitations and advanced drug delivery. This article reviews the current chitosan derivatives used in biomedical applications and discusses their importance in oral drug delivery. It points out the limited use of chitosan resources in oral drug delivery and possible reasons for this.
Article
Biochemistry & Molecular Biology
Yuri Basilio Gomes Patriota, Igor Eduardo Silva Arruda, Antonia Carla de Jesus Oliveira, Thaisa Cardoso de Oliveira, Eliadna de Lemos Vasconcelos Silva, Luise Lopes Chaves, Fabio de Oliveira Silva Ribeiro, Durcilene Alves da Silva, Monica Felts de la Roca Soares, Jose Lamartine Soares-Sobrinho
Summary: Eudragit (R) L100 coated chitosan core shell nanoparticles were successfully developed for oral delivery of enoxaparin, showing good colloidal stability and controlled drug release mechanism. The study demonstrates the potential of enteric-coating approach and drug delivery nanotechnology for oral administration of enoxaparin.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Multidisciplinary
Mengting Lv, Huanan Li, Hua Cao, Teng Wang, Chengdian He, Yi Liang, Xiang Mao, Zhenyu Wang
Summary: This study presents a novel alkaline-responsive drug carrier, CS-GL, fabricated using a microfluidic approach with ultrasound assistance. The carrier exhibits high drug encapsulation efficiency and stable structure, enabling rapid drug release under both acidic and alkaline conditions.
Article
Pharmacology & Pharmacy
Bo Fan, Lan Liu, Ying Zheng, Yang Xing, Weiguang Shen, Qian Li, Ruyi Wang, Guixian Liang
Summary: LMWH has a great anticoagulant effect, but its oral administration is hindered. A pH-responsive delivery system was developed to protect LMWH and facilitate absorption. The system showed good nanoparticle shape and stability, and controlled drug release in different pH environments, leading to enhanced bioavailability and antithrombotic effect.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Nafiseh Hosseini-Ashtiani, Azadeh Tadjarodi, Rouholah Zare-Dorabei
Summary: This study aimed to develop a safe nano-drug carrier using chitosan and cyanocobalamin for enhanced oral delivery of ciprofloxacin hydrochloride. The optimized drug loading efficiency and controlled release patterns demonstrated the potential of this chitosan-based nano-drug delivery system for oral administration of CIP.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Huda S. AlSalem, Nisreen M. Abdulsalam, Najla A. Khateeb, Mona S. Binkadem, Nahlah A. Alhadhrami, Abdalla M. Khedr, Rehab Abdelmonem, Kamel R. Shoueir, Eman Hassan Nadwa
Summary: Chitosan was modified and functionalized to improve oral insulin delivery. The Cs-DNS NPs had a particle size of 33.29 ± 5.08 nm and positive zeta potential. In vitro experiments showed high insulin entrapment efficiency and gradual release at different pH levels. In vivo experiments demonstrated that insulin-incorporated Cs-DNS NPs effectively lowered serum glucose levels, with a bioavailability of 17.5 ± 0.31% and pharmacological availability of 8.6 ± 0.8%.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Polymer Science
Cleidiane Goncalves, Nelson Ferreira, Lucia Lourenco
Summary: Chitosan's molecular weight can be regulated through different hydrolysis methods, with acid hydrolysis being the most commonly used method, but may cause environmental impacts. Combining different hydrolysis methods may be the most effective approach, although it could increase costs. Enzymatic hydrolysis is widely studied due to its environmental advantages and high specificity, but factors such as hydrolysis time and cost still limit its industrial application.
Article
Pharmacology & Pharmacy
Gamze Ruzgar Ozemre, Adnan Altug Kara, Esra Pezik, Serdar Tort, Imran Vural, Fusun Acarturk
Summary: The aim of this study was to develop and evaluate nanodelivery systems to increase the oral bioavailability of enoxaparin (low molecular weight heparin). Nanosystems such as three-layered nanofiber membrane (NF), enoxaparin loaded nanoparticles (NP) and three-layered nanofiber membrane loaded with enoxaparin nanoparticles (NP/NF) were prepared. The results showed that the nanodelivery systems were successful in increasing the oral bioavailability of enoxaparin and protecting it from the acid pH of the stomach.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Green & Sustainable Science & Technology
Danfeng Wang, Ruiying Song, Yue Liu, Jingyu Ren, Ying Zhang, Tiecheng Wang, Guangzhou Qu
Summary: This study developed a method to simultaneously produce low molecular weight chitosan and reducing sugars through chitosan depolymerization by surface discharge plasma. Active oxygen species and radicals in the discharge plasma played important roles in degrading chitosan and forming low molecular weight chitosan, which ultimately increased its biological activity. Discharge plasma could be an effective technique for chitosan depolymerization, expanding its potential applications.
JOURNAL OF CLEANER PRODUCTION
(2021)
Article
Chemistry, Applied
A. Pandit, L. Khare, P. Ganatra, R. Jain, P. Dandekar
Summary: A green technique for hydrolysis of chitosan was developed using novel Brønsted Acidic Ionic Liquids (BAILs) as homogenous reusable catalysts. The efficiency of BAILs in controlling the breakdown of chitosan was compared with mineral acids, showing promising results in consistent production of low molecular weight chitosan variants. Structural elucidation of BAILs was performed using various methods, confirming their potential for application in chitosan conversion processes.
CARBOHYDRATE POLYMERS
(2021)
Article
Polymer Science
Zhenyu Xu, Long Chen, Xiaoya Duan, Xueming Li, Hao Ren
Summary: A novel oral delivery system of insulin called NiM, based on a three-dimensional system of biocompatible chitosan/alginate/casein, has been developed to overcome the GI barriers. NiM showed stable hydrodynamic parameters and effectively controlled the release of insulin in gastric and intestinal tracts, demonstrating promising results for diabetic patients.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2021)
Article
Pharmacology & Pharmacy
Li Shangyong, Zhang Hui, Chen Kaiwei, Jin Mengfei, Vu Son Hai, Samil Jung, He Ningning, Zheng Zhou, Myeong-Sok Lee
Summary: Oral drug delivery systems have advantages of simplicity and minimal side effects, making them suitable for colon-targeted therapy. Chitosan/alginate nanoparticles (CANPs) show potential in the treatment of intestinal diseases due to their strong electrostatic interaction and intestinal mucosal adhesion.
Article
Immunology
Hai-yu Ji, Chao Liu, Ke-yao Dai, Juan Yu, An-jun Liu, Ye-fu Chen
Summary: This study investigated the immunosuppressive effects of low molecular weight chitosan on mice with solid tumors, revealing its ability to disrupt immune organs, suppress immune cell activity, and decrease the expression of immune-related cytokines. The findings suggest that chitosan may not enhance immune response in cancer patients, but could be utilized in the treatment of autoimmune diseases or organ transplant recipients.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Katrin Zoeller, Flavia Laffleur, Victor Claus, Patrick Knoll, Dennis To, Andreas Bernkop-Schnuerch
Summary: The aim of this study was to develop and evaluate different types of nanoemulsions for oral delivery of low molecular weight heparin (LMWH). Hydrophobic ion pairs were formed to incorporate LMWH in the oily droplets. The non-digestible nanoemulsions were found to improve the oral bioavailability of LMWH more efficiently than biodegradable formulations.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)