Article
Biochemistry & Molecular Biology
Mei Hu, Yan Jiang, Jing-Jing Xu
Summary: This study demonstrated that Coq9 plays a critical role in CoQ biosynthesis in plants, and its disruption results in lower CoQ content. These findings provide new insights into the evolution of CoQ biosynthesis in plants.
Article
Physiology
Juan Diego Hernandez-Camacho, Daniel J. M. Fernandez-Ayala, Cristina Vicente-Garcia, Ignacio Navas-Enamorado, Guillermo Lopez-Lluch, Clara Oliva, Rafael Artuch, Judith Garcia-Villoria, Antonia Ribes, Rafael de Cabo, Jaime J. Carvajal, Placido Navas
Summary: ADCK2 haploinsufficiency leads to mitochondrial coenzyme Q deficiency in skeletal muscle, causing mitochondrial myopathy and defects in beta-oxidation of fatty acids. Calorie restriction improves glucose and fatty acid metabolism, enhances mitochondrial function and differentiation, and increases physical performance in mutant mice.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Michael D. Guile, Akash Jain, Kyle A. Anderson, Catherine F. Clarke
Summary: Coenzyme Q (CoQ) is a vital lipid that plays multiple cellular functions, including cellular respiration, antioxidant protection, redox homeostasis, and ferroptosis suppression. Deficiencies in CoQ can be ameliorated by high-dose supplementation, and understanding its uptake and transport can improve clinical use and deficiency treatment. This review summarizes the current knowledge of CoQ uptake and intracellular distribution in yeast, mammalian cell culture, rodent models, and organism level absorption. The literature suggests that CoQ uptake and distribution are complex processes involving the endomembrane system and newly identified lipid transporters, with impairment causing significant effects on metabolism and stress response. Furthermore, significant gaps in our understanding of CoQ distribution within the cell are identified, suggesting future research directions.
Article
Biochemistry & Molecular Biology
Naig Gueguen, Olivier Baris, Guy Lenaers, Pascal Reynier, Marco Spinazzi
Summary: This article provides an overview of Coenzyme Q (CoQ) distribution in cells and tissues, secondary CoQ deficiency in neurological diseases, and therapeutic strategies for CoQ supplementation. It also discusses improvements in CoQ absorption, formulations, and imaging techniques.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Nathan H. Murray, Christopher R. M. Asquith, Zixiang Fang, Michael P. East, Naomi Ptak, Robert W. Smith, James D. Vasta, Chad A. Zimprich, Cesear R. Corona, Matthew B. Robers, Gary L. Johnson, Craig A. Bingman, David J. Pagliarini
Summary: In this study, a selective inhibitor for COQ8A was developed and characterized using crystallography, activity assays, and cellular measurements. This chemical tool provides insights into the activities of understudied proteins and offers potential therapeutic strategies for human diseases associated with their dysfunction.
NATURE CHEMICAL BIOLOGY
(2023)
Article
Clinical Neurology
Ioannis Manolaras, Andrea Del Bondio, Olivier Griso, Laurence Reutenauer, Aurelie Eisenmann, Bianca H. Habermann, Helene Puccio
Summary: Manolaras et al. demonstrate that COQ8A-ataxia is primarily caused by mitochondrial dysfunction leading to calcium dysregulation in Purkinje neurons of the cerebellum. These abnormalities can be rescued in vitro by treatment with coenzyme Q10. It is a rare form of neurodegenerative disorder due to mutations in the COQ8A gene. The loss of COQ8A in Purkinje neurons is the main cause of cerebellar ataxia, resulting in abnormal dendritic arborizations, altered mitochondria function, and intracellular calcium dysregulation. Furthermore, they show that oxidative phosphorylation, particularly Complex IV, is primarily altered at presymptomatic stages of the disease, and CoQ10 treatment could rescue the pathology.
Review
Biochemistry & Molecular Biology
Jing-Jing Xu, Mei Hu, Lei Yang, Xiao-Ya Chen
Summary: This article summarizes the research progress on CoQ biosynthesis and regulation in plants and recent efforts to increase the CoQ content in plant foods.
PLANT COMMUNICATIONS
(2022)
Review
Biochemistry & Molecular Biology
Carlos Santos-Ocana, Maria V. Cascajo, Maria Alcazar-Fabra, Carmine Staiano, Guillermo Lopez-Lluch, Gloria Brea-Calvo, Placido Navas
Summary: Primary coenzyme Q(10) deficiency is a group of mitochondrial diseases characterized by low mitochondrial levels of CoQ due to decreased endogenous biosynthesis rate, which respond to CoQ treatment mainly at the early stages. Advances in next generation sequencing have increased the discoveries of mutations in genes involved in CoQ biosynthesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biology
James Robertson, Andrew Jeffs, Christopher Hedges, Anthony J. R. Hickey
Summary: Isoeugenol, an anaesthetic used in the transportation of live lobsters, acts as a metabolic suppressant, reducing energy expenditure and improving survival rates. This study investigates the impact of isoeugenol on mitochondrial function, with a particular focus on respiration supported by complex I and cytochrome c oxidase. The results demonstrate that isoeugenol inhibits respiration through complex I and indicates it may act as a possible target for isoeugenol's effects.
JOURNAL OF EXPERIMENTAL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Catarina M. Quinzii, Luis C. Lopez
Summary: Mitochondrial disorders are genetic diseases with inadequate therapy due to the heterogeneity and tissue-specificity of pathomechanisms. Abnormalities in hydrogen sulfide (H2S) metabolism are emerging as a novel mechanism in mitochondrial dysfunction, but further studies are needed to understand the effects and relevance in mitochondrial diseases. The review focuses on derangement of H2S metabolism in primary Coenzyme Q (CoQ) deficiency and emphasizes the need for more research on the consequences of abnormalities in H2S and GSH synthesis on the oxidation pathway.
JOURNAL OF ADVANCED RESEARCH
(2021)
Article
Gastroenterology & Hepatology
Sarra Smati, Arnaud Polizzi, Anne Fougerat, Sandrine Ellero-Simatos, Yuna Blum, Yannick Lippi, Marion Regnier, Alexia Laroyenne, Marine Huillet, Muhammad Arif, Cheng Zhang, Frederic Lasserre, Alain Marrot, Talal Al Saati, JingHong Wan, Caroline Sommer, Claire Naylies, Aurelie Batut, Celine Lukowicz, Tiffany Fougeray, Blandine Tramunt, Patricia Dubot, Lorraine Smith, Justine Bertrand-Michel, Nathalie Hennuyer, Jean-Philippe Pradere, Bart Staels, Remy Burcelin, Francoise Lenfant, Jean-Francois Arnal, Thierry Levade, Laurence Gamet-Payrastre, Sandrine Lagarrigue, Nicolas Loiseau, Sophie Lotersztajn, Catherine Postic, Walter Wahli, Christophe Bureau, Maeva Guillaume, Adil Mardinoglu, Alexandra Montagner, Pierre Gourdy, Herve Guillou
Summary: The study found that different diets induced more severe NAFLD in male mice, characterized by lipid accumulation and inflammation/fibrosis. Sex-biased hepatic gene signatures showed different responses to various dietary challenges, with Peroxisome proliferator-activated receptor alpha (PPAR alpha) playing a key role in gender-specific and NAFLD pathophysiology.
Review
Pharmacology & Pharmacy
Qingyun Tan, Yuying Fang, Qiong Gu
Summary: Ferroptosis is a novel form of programmed cell death involving iron metabolism and CNS diseases, which may offer new perspectives for the development of therapeutic agents.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Juan Diego Hernandez-Camacho, Laura Garcia-Corzo, Daniel Jose Moreno Fernandez-Ayala, Placido Navas, Guillermo Lopez-Lluch
Summary: Coenzyme Q is a crucial lipidic molecule essential for maintaining aerobic metabolism, promoting ATP synthesis in mitochondria, exerting antioxidant functions in cellular membranes, regulating cellular redox homeostasis, and controlling various apoptosis mechanisms. Its levels and reactions play important roles in aging, age-associated metabolic disorders, and combating diseases, as well as enhancing physical performance in aging individuals.
Article
Biochemistry & Molecular Biology
Zuzana Sumbalova, Jarmila Kucharska, Zuzana Rausova, Anna Gvozdjakova, Maria Szantova, Branislav Kura, Viliam Mojto, Jan Slezak
Summary: This study investigated the effects of hydrogen-rich water on coenzyme Q10 content and platelet mitochondrial bioenergetics in patients with non-alcoholic fatty liver disease (NAFLD). The results showed that drinking hydrogen-rich water can increase coenzyme Q10 concentration, reduce oxidative stress levels, and improve mitochondrial function, suggesting a potential therapeutic effect on NAFLD patients' recovery.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Urology & Nephrology
Xiaoqin Zhang, Linda Xiaoyan Li, Hao Ding, Vicente E. Torres, Chen Yu, Xiaogang Li
Summary: The study found that ferroptosis plays a role in the progression of ADPKD, suggesting that managing ferroptosis could be a novel treatment strategy for ADPKD.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Brahim Belbellaa, Laurence Reutenauer, Laurent Monassier, Helene Puccio
HUMAN MOLECULAR GENETICS
(2019)
Review
Neurosciences
Matthis Synofzik, Helene Puccio, Fanny Mochel, Ludger Schoels
Article
Clinical Neurology
Andreas Traschuetz, Tommaso Schirinzi, Lucia Laugwitz, Nathan H. Murray, Craig A. Bingman, Selina Reich, Jan Kern, Anna Heinzmann, Gessica Vasco, Enrico Bertini, Ginevra Zanni, Alexandra Durr, Stefania Magri, Franco Taroni, Alessandro Malandrini, Jonathan Baets, Peter de Jonghe, Willem de Ridder, Matthieu Bereau, Stephanie Demuth, Christos Ganos, A. Nazli Basak, Hasmet Hanagasi, Semra Hiz Kurul, Benjamin Bender, Ludger Schoels, Ute Grasshoff, Thomas Klopstock, Rita Horvath, Bart van de Warrenburg, Lydie Burglen, Christelle Rougeot, Claire Ewenczyk, Michel Koenig, Filippo M. Santorelli, Mathieu Anheim, Renato P. Munhoz, Tobias Haack, Felix Distelmaier, David J. Pagliarini, Helene Puccio, Matthis Synofzik
ANNALS OF NEUROLOGY
(2020)
Article
Clinical Neurology
Andreas Traschutz, Andrea Cortese, Selina Reich, Natalia Dominik, Jennifer Faber, Heike Jacobi, Annette M. Hartmann, Dan Rujescu, Solveig Montaut, Andoni Echaniz-Laguna, Sevda Erer, Valerie Cornelia Schutz, Alexander A. Tarnutzer, Marc Sturm, Tobias B. Haack, Nadege Vaucamps-Diedhiou, Helene Puccio, Ludger Schols, Thomas Klockgether, Bart P. van de Warrenburg, Martin Paucar, Dagmar Timmann, Ralf-Dieter Hilgers, Jose Gazulla, Michael Strupp, German Moris, Alessandro Filla, Henry Houlden, Mathieu Anheim, Jon Infante, A. Nazli Basak, Matthis Synofzik
Summary: The study found that RFC1 disease is common across different populations, with CANVAS and ACC as highly diagnostic features, but the phenotype is variable and overlapping, spanning a spectrum of multisystem diseases. Treatment trials require a large number of patients to detect reduced progression.
Article
Medicine, Research & Experimental
Brahim Belbellaa, Laurence Reutenauer, Nadia Messaddeq, Laurent Monassier, Helene Puccio
MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT
(2020)
Article
Clinical Neurology
Solveig Montaut, Nadege Diedhiou, Pauline Fahrer, Cecilia Marelli, Benoit Lhermitte, Laura Robelin, Marie Claire Vincent, Lucas Corti, Guillaume Taieb, Odile Gebus, Gabrielle Rudolf, Julien Tarabeux, Nicolas Dondaine, Matthieu Canuet, Marilyne Almeras, Mehdi Benkirane, Lise Larrieu, Jean-Baptiste Chanson, Aleksandra Nadaj-Pakleza, Andoni Echaniz-Laguna, Cecile Cauquil, Beatrice Lannes, Jamel Chelly, Mathieu Anheim, Helene Puccio, Christine Tranchant
Summary: CANVAS is a recessively inherited multisystem ataxia associated with RFC1 repeat expansions. In a French cohort, 15 patients with CANVAS phenotype were identified in idiopathic late-onset ataxia cases, but not in MSA-C patients. The study confirms the genetic heterogeneity of CANVAS and suggests searching for RFC1 repeat expansions in unexplained ILOA cases with sensory neuronopathy.
JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Arnaud Jacquier, Julian Theuriet, Fanny Fontaine, Valentine Mosbach, Nicolas Lacoste, Shams Ribault, Valerie Risson, Julien Carras, Laurent Coudert, Thomas Simonet, Philippe Latour, Tanya Stojkovic, Juliette Piard, Anne Cosson, Gaetan Lesca, Francoise Bouhour, Stephane Allouche, Helene Puccio, Antoine Pegat, Laurent Schaeffer
Summary: Jacquier et al. identified a homozygous variant in the COQ7 gene in a family with distal hereditary motor neuropathy. This variant leads to a decrease in coenzyme Q10 production, causing impaired mitochondrial metabolism. Coenzyme Q10 supplementation may serve as a potential treatment for this disorder.
Article
Genetics & Heredity
Louise A. Corben, Veronica Collins, Sarah Milne, Jennifer Farmer, Ann Musheno, David Lynch, Sub Subramony, Massimo Pandolfo, Joerg B. Schulz, Kim Lin, Martin B. Delatycki
Summary: To improve clinical care for FRDA patients, the GRADE rare-disease framework was adopted, incorporating additional strategies to support the strength of recommendations. The study generated 130 new recommendations and 95 best practice statements.
ORPHANET JOURNAL OF RARE DISEASES
(2022)
Article
Clinical Neurology
Ioannis Manolaras, Andrea Del Bondio, Olivier Griso, Laurence Reutenauer, Aurelie Eisenmann, Bianca H. Habermann, Helene Puccio
Summary: Manolaras et al. demonstrate that COQ8A-ataxia is primarily caused by mitochondrial dysfunction leading to calcium dysregulation in Purkinje neurons of the cerebellum. These abnormalities can be rescued in vitro by treatment with coenzyme Q10. It is a rare form of neurodegenerative disorder due to mutations in the COQ8A gene. The loss of COQ8A in Purkinje neurons is the main cause of cerebellar ataxia, resulting in abnormal dendritic arborizations, altered mitochondria function, and intracellular calcium dysregulation. Furthermore, they show that oxidative phosphorylation, particularly Complex IV, is primarily altered at presymptomatic stages of the disease, and CoQ10 treatment could rescue the pathology.
Article
Neurosciences
Danique Beijer, Brent Fogel, Sergi Beltran, Matt Danzi, Andrea Nemeth, Stephan Zuchner, Matthis Synofzik
Summary: The Ataxia Global Initiative (AGI) is a global research platform aiming to enhance trial-readiness in degenerative ataxias. The AGI NGS working group focuses on improving methods for ataxia NGS analysis and data sharing to increase the number of genetically diagnosed ataxia patients. Collaboration between AGI and other research platforms has led to the diagnosis of over 500 ataxia patients and the discovery of more than 30 novel ataxia genes. The AGI NGS working group presents consensus recommendations for NGS data sharing initiatives, emphasizing harmonized variant analysis and standardized clinical and metadata collection.
Article
Clinical Neurology
Chiara Dionisi, Marine Chazalon, Myriam Rai, Celine Keime, Virginie Imbault, David Communi, Helene Puccio, Serge N. Schiffmann, Massimo Pandolfo
Summary: This study characterizes the abnormalities in neurons of Friedreich ataxia, demonstrating impaired cytoskeleton organization, neurite extension, synaptic plasticity, and altered electrophysiological profiles. Despite restoration of FXN expression, isogenic control neurons still exhibit characteristics of Friedreich ataxia neurons.
BRAIN COMMUNICATIONS
(2022)
Meeting Abstract
Biotechnology & Applied Microbiology
B. Belbellaa, V. Bonnamain, S. M. Kaminsky, D. Sondhi, J. Rosenberg, K. Kozarsky, H. Puccio, R. G. Crystal, M. Gasmi
HUMAN GENE THERAPY
(2019)
Meeting Abstract
Immunology
F. Arbogast, D. Bouis, L. Filippi De La Palavesa, O. Griso, H. Puccio, A. Molitor, R. Carapito, S. Bahram, N. Romani, B. E. Clausen, C. G. Mueller, F. Gros, V. Flacher
EUROPEAN JOURNAL OF IMMUNOLOGY
(2019)
Meeting Abstract
Biotechnology & Applied Microbiology
Helene Puccio, Martin Goulet, Ada Felix-Ortiz, Holly Lindgren, Maria Scheel, Eric Horowitz, Yanqun Shu, Dinah Sah, Francoise Piguet, Holger Patzke
Meeting Abstract
Biotechnology & Applied Microbiology
Brahim Belbellaa, Laurence Reutenauer, Laurent Monassier, Helene Puccio
Article
Biochemistry & Molecular Biology
Siva Santhiya Arul, Brinda Balakrishnan, Savithri S. Handanahal, Sangita Venkataraman
Summary: Viral nanoparticles are self-assembling delivery systems used for vaccines and therapeutic agents. They have improved biocompatibility and are widely used in various biomedical applications. However, large-scale production of VNPs still faces challenges.
Article
Biochemistry & Molecular Biology
Wisely Chua, Carl O. Marsh, Si En Poh, Winston LC. Koh, Melody Li Ying Lee, Li Fang Koh, Xin-Zi Emily Tang, Peter See, Zheng Ser, Shi Mei Wang, Radoslaw M. Sobota, Thomas L. Dawson Jr, Yik Weng Yew, Steven Thng, Anthony J. O'Donoghue, Hazel H. Oon, John E. Common, Hao Li
Summary: In this study, the gene expression of enzymes secreted by Malassezia globosa in the skin was investigated using targeted RNA sequencing. The study found that the expression of these enzymes is regulated by the fungus's environment and differs significantly from healthy skin sites. Additionally, a pseudoprotease MGL_3331 was identified to elicit an immune reaction in patients with atopic dermatitis. This highlights the importance of studying fungal proteins in physiologically relevant environments and their role in host immunity.
Article
Biochemistry & Molecular Biology
Belisa Parmeggiani, Marian Flores Signori, Cristiane Cecatto, Marina Rocha Frusciante, Manuela Bianchin Marcuzzo, Debora Guerini Souza, Rafael Teixeira Ribeiro, Bianca Seminotti, Diogo Onofre Gomes de Souza, Cesar Augusto Joa o Ribeiro, Moacir Wajner, Guilhian Leipnitz
Summary: Non ketotic hyperglycinemia (NKH) is a disorder caused by mutations in the genes encoding glycine cleavage system proteins, leading to severe neurodegeneration and white matter alterations. The study found that glycine affects myelin structure, glutamatergic system, and induces oxidative stress in neonatal rats and MO3.13 oligodendroglial cells.
Review
Biochemistry & Molecular Biology
Marie Rose Ndella Thiaw, Pascal Gantet
Summary: Mini zinc fingers play important roles in plant development, including control of cell division and expansion, meristem state transition, and growth and organ development. They have diverse modes of action, such as direct gene activation, interaction with specific transcription factors, and aggregation of protein complexes for chromatin remodeling. Further research is needed to explore their wider range of biological functions and their involvement in biotic and abiotic stress responses.
Article
Biochemistry & Molecular Biology
Shao-Jui Lai, Takahiro Kameda, Maasa Morita, Yuka Yamagata, Kaoruko Nishizaka, Yuna Horiuchi, Yukihiro Kobayashi, Yoko Usami, Jun-Jen Liu, Takeshi Kasama, Minoru Tozuka, Ryunosuke Ohkawa
Summary: In this study, the co-modification and impact of chymase and MPO on HDL were investigated. Sequential treatment with MPO and chymase generated two novel apoA-I fragments from HDL, one of which has a specific immunological property and can be used to predict patients with normal HDL-C levels and cardiovascular diseases.
Article
Biochemistry & Molecular Biology
Xiao-Mi Sun, Asami Yoshida, Takuya Ishii, Yan-Rong Jiang, Yi-Li Gao, Mikinori Ueno, Katsuya Hirasaka, Kiyoshi Osatomi
Summary: This study found that infection with the causative bacteria of edwardsiellosis, Edwardsiella tarda NUF251, leads to the production of superoxide radicals, causing oxidative stress. The research on the Jfsod1 gene suggests that the transcription factor NF-IL6 plays a significant role in upregulating the transcriptional activity of the gene in response to oxidative stress induced by NUF251 infection.
Article
Biochemistry & Molecular Biology
Shane M. Carey, Sean P. Kearns, Matthew E. Millington, Gregory S. Buechner, Beda E. Alvarez Jr, Leily Daneshian, Brendan Abiskaroon, Maksymilian Chruszcz, Edward L. D'Antonio
Summary: The importance of F337 in TcGlcK was investigated using the hole mutagenesis approach, revealing its key interactions with aromatic tail groups in inhibitor molecules. Mutants retaining activity and structural similarity were obtained, suggesting the possibility of TcHxK existing as a monomer lacking the F337 residue. Similar D-glucosamine inhibitors may bind less strongly to TcHxK due to the absence of van der Waals contacts from residue side chains.
Article
Biochemistry & Molecular Biology
Catia Barria, Diogo Athayde, Guillem Hernandez, Leonor Fonseca, Jorge Casinhas, Tiago N. Cordeiro, Margarida Archer, Cecilia M. Arraiano, Jose A. Brito, Rute G. Matos
Summary: Ribonucleases play a crucial role in RNA regulation by processing, degrading, and quality controlling cellular transcripts. Campylobacter jejuni, the main cause of human gastroenteritis, relies on the exoribonuclease PNPase (CjPNP) for low-temperature survival, virulence factor synthesis, and swimming, cell adhesion/invasion, and chick colonization abilities. The crystallographic structure of CjPNP, along with SAXS analysis, confirms its trimeric arrangement and provides insight into domain arrangement and flexibility. Mutations in highly conserved residues reveal unexpected RNA degradation activity even under conditions favoring polymerization. These findings have significant implications for the development of strategies to combat C. jejuni infections.
Article
Biochemistry & Molecular Biology
Elvira R. Shaykhutdinova, Maria S. Severyukhina, Inna V. Kholoshenko, Elena A. Gondarenko, Irina V. Shelukhina, Elena V. Kryukova, Alina M. Ismailova, Elena S. Sadovnikova, Igor A. Dyachenko, Arkady N. Murashev, Victor I. Tsetlin, Yuri N. Utkin
Summary: Evidence suggests that activating nicotinic acetylcholine receptors (nAChRs) can reduce cardiac injury caused by ischemia and reperfusion. In this study, the expression of a4, a6, and a132 nAChR subunits in the rat heart's left ventricle was demonstrated. The nAChR agonists cytisine and varenicline, commonly used for nicotine addiction treatment, were found to significantly reduce myocardial ischemia-reperfusion injury, with varenicline showing greater protection. The presence of a4132, a7, and/or a6132-containing receptors suggests that the protective effect of varenicline may be mediated by these subunits. These findings indicate a potential new use for cytisine and varenicline as cardioprotective agents.
Article
Biochemistry & Molecular Biology
Xinhai Xiong, Wenjie Chen, Cheng Chen, Qi Wu, Chaopeng He
Summary: This article summarizes the important roles of Cx43 in disease development from the perspective of subcellular localization and provides new ideas for Cx43 as a therapeutic target and the search for related pathological mechanisms.
Article
Biochemistry & Molecular Biology
Veronica Bastos, Simone Pascoal, Kamila Lopes, Marcia Mortari, Helena Oliveira
Summary: Cancer, especially melanoma, is a major global health problem due to its metastatic capacity, treatment resistance, and high mortality rates. The Chartergellus-CP1 peptide isolated from Chartergellus communis wasp venom showed selective cytotoxicity towards melanoma cell lines, inducing apoptosis, cell cycle impairment, and intracellular ROS increase.
Article
Biochemistry & Molecular Biology
Charlotte Claeyssen, Nathan Bulangalire, Bruno Bastide, Onnik Agbulut, Caroline Cieniewski-Bernard
Summary: Maintenance of striated muscle tissue relies on a dynamic network of protein-protein interactions. Desmin intermediate filaments play a crucial role in heart and skeletal muscle by maintaining cell structure and contributing to various cellular processes. The assembly of desmin intermediate filaments requires aB-crystallin, which is involved in multiple cellular functions.
Article
Biochemistry & Molecular Biology
Dhritiman Dey, Adhiraj Dasgupta, Dipanjan Ghosh, Oindrila Bhattacharjee, Abhrajyoti Ghosh, Ayae Honda, Dhrubajyoti Chattopadhyay
Summary: This study successfully identified host factors that interact with Chandipura Virus (CHPV) and play a critical role in infection, including A2M, LRP1, and GRP78. Knocking out A2M has a severe effect on viral infection, indicating the potential role of these host proteins in viral entry into host cells.
Article
Biochemistry & Molecular Biology
Anna Dotsenko, Igor Sinelnikov, Aleksandra Rozhkova, Ivan Zorov, Arkady Sinitsyn
Summary: Xylanases play important roles in various industrial applications, such as feed additives, pulp and paper bleaching, and the production of bread, food, and drinks. Xylanases from the GH10 family show high thermostability and resistance to protein inhibitors, making them promising candidates for these processes. This study successfully improved the thermostability and enzymatic activity of GH10 xylanase, which could enhance its effectiveness as a feed additive and during pulp and paper bleaching.
Article
Biochemistry & Molecular Biology
M. Jaquet, M. Bengue, K. Lambert, G. Carnac, D. Misse, C. Bisbal
Summary: Changes to our environment have led to the emergence of human pathogens such as chikungunya virus, which is now a major public health concern. In this study, the interconnection between skeletal muscle cells metabolism, their differentiation stage, and the infectivity of chikungunya virus was investigated. The results showed that chikungunya virus infectivity is dependent on cell differentiation and metabolism and that the virus interferes with cellular metabolism.
