Article
Cell Biology
Thomas Kuntzel, Caroline Spenle, Lucas D. Pham-Van, Dafni Birmpili, Aurelien Riou, Aurore Loeuillet, Imane Charmarke-Askar, Dominique Bagnard
Summary: IL-10 exerts anti-inflammatory and immune regulatory roles through its interaction with the IL-10 receptor (IL-10R), which consists of two subunits (IL-10R alpha and IL-10R beta). This study explores the activation patterns of IL-10R and the potential of targeting its transmembrane domain (TM) using peptide mimics. The results demonstrate the involvement of the TM domains from both subunits in receptor activation and suggest that targeting the TM domain could be a new strategy for modulating inflammation.
Article
Food Science & Technology
Chia-Ying Lin, Sheng-Yi Chen, Wei-Ting Lee, Gow-Chin Yen
Summary: Camellia oil, rich in oleic acid and antioxidants, has been found to enhance phagocytosis in macrophages, reduce nitric oxide production, induce interleukin-10, and promote the CD19+ B cell population, showing significant immunomodulatory effects.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Chemistry, Applied
Lingrong Wen, Yueming Jiang, Xuesong Zhou, Huimin Bi, Bao Yang
Summary: Soybean peptides are functional foods with health benefits, with their structure playing a key role in determining these benefits. By identifying peptide structure and evaluating immunomodulatory activity, soybean peptides were found to facilitate macrophage proliferation.
Article
Biochemistry & Molecular Biology
Sunisa Khongthong, Yongyuth Theapparat, Natthrit Roekngam, Chinnapatch Tantisuwanno, Michael Otto, Pipat Piewngam
Summary: Sulfated galactans (SG) isolated from G. fisheri, particularly SG-1, with an estimated molecular mass of 100 kDa, activate murine macrophages via the dectin-1 signaling pathway, enhancing nitric oxide secretion and mRNA levels of pro-inflammatory cytokines. Treatment with G. fisheri SG-1 displays immune-stimulatory activities comparable to or surpassing lipopolysaccharide treatment.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Food Science & Technology
Veronika Weiss, Martina Gobec, Ziga Jakopin
Summary: This study investigated the immunomodulatory properties of eight different types of organic UV filters. The results showed that two of them, avobenzone and 3-benzy-lidene camphor, increased IL-8 secretion from THP-1 cells and THP-1 derived macrophages, while also decreasing IL-6 and IL-10 release from lipopolysaccharide-stimulated peripheral blood mononuclear cells.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Fisheries
Zeinab Hassan, Junya Wang, Yuting Qin, Wei Wang, Qin Liu, Lina Lei, Zhaosheng Sun, Yibin Yang, Kaizheng Wu, Xiaozhen Zhu, Zixuan Wang, Hao Feng, Jun Zou
Summary: IL-20, a pleiotropic cytokine, has been cloned in grass carp and shown to be inducible in head kidney leukocytes and macrophages. The recombinant CiIL-20L was able to induce expression of various cytokine and inflammation genes, suggesting a potential regulatory role in promoting immune responses and inflammation.
FISH & SHELLFISH IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Igor A. Schepetkin, Marina G. Danilets, Anastasia A. Ligacheva, Evgenia S. Trofimova, Natalia S. Selivanova, Evgenii Yu. Sherstoboev, Sergei V. Krivoshchekov, Ekaterina I. Gulina, Konstantin S. Brazovskii, Liliya N. Kirpotina, Mark T. Quinn, Mikhail V. Belousov
Summary: Polysaccharides extracted from Saussurea plants have immunomodulatory activity, inducing nitric oxide production and activating cytokine secretion. These polysaccharides exert therapeutic effects by regulating leukocyte functions.
Article
Allergy
Kittipong Maneechotesuwan, Kanda Kasetsinsombat, Adisak Wongkajornsilp, Peter J. Barnes
Summary: This study investigated the role of autophagy in promoting inflammation in asthma through reducing IL-10 secretion in macrophages. It found that corticosteroids and statins inhibit autophagy in macrophages, leading to increased IL-10 production and control of asthmatic inflammation.
CLINICAL AND EXPERIMENTAL ALLERGY
(2021)
Article
Engineering, Biomedical
J. Barthes, P. Lagarrigue, V. Riabov, G. Lutzweiler, J. Kirsch, C. Muller, E. -J. Courtial, C. Marquette, F. Projetti, J. Kzhyskowska, P. Lavalle, N. E. Vrana, A. Dupret-Bories
Summary: A new cytokine cocktail and hydrogel were designed to control immune responses, promote tissue integration, and increase the survival rate of implants. In vivo experiments demonstrated that implants coated with this hydrogel could reduce inflammatory reactions and significantly improve animal survival rates.
Article
Food Science & Technology
Dorsaf Bouzazi, Wael Mami, Amor Mosbah, Naziha Marrakchi, Melika Ben Ahmed, Erij Messadi
Summary: Snake natriuretic peptide (NP) Lebetin 2 (L2) has anti-inflammatory effects by regulating the release of inflammatory cytokines and promoting M2 macrophage polarization through activation of IL-10 signaling. L2 increases IL-10 release in a sustained manner and promotes downstream M2 macrophage polarization, while reducing TNF-alpha and IL-6 release in lipopolysaccharide (LPS)-activated cells. The effect of L2 is mediated by stimulating NP receptors.
Article
Dentistry, Oral Surgery & Medicine
John A. Pizarek, Nicholas G. Fischer, Conrado Aparicio
Summary: The study synthesized an IL-23R antagonist peptide nanocoating on titanium surfaces to reduce inflammation around dental implants and promote soft tissue healing.
Article
Immunology
Mingyue Zhang, Jintong Chen, Hua Zhang, He Dong, Ying Yue, Siqing Wang
Summary: This study found that IL-10 enhances chemotherapy resistance in multiple myeloma through the FABP5 signaling pathway in macrophages. Targeting FABP5 may have important clinical implications.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Victor D. Cuevas, Miriam Simon-Fuentes, Emmanuel Orta-Zavalza, Rafael Samaniego, Paloma Sanchez-Mateos, Maria Escribese, Francisco J. Cimas, Matilde Bustos, Mario Perez-Diego, Alberto Ocana, Angeles Dominguez-Soto, Miguel A. Vega, Angel L. Corbi
Summary: During inflammatory responses, monocytes can differentiate into monocyte-derived macrophages with distinct transcriptional profiles, which are partially regulated by IL-10. This specific gene expression signature may provide potential targets for macrophage-centered therapeutic strategies.
JOURNAL OF INNATE IMMUNITY
(2022)
Article
Biochemistry & Molecular Biology
Colin Shortridge, Ehsan Akbari Fakhrabadi, Leah M. Wuescher, Randall G. Worth, Matthew W. Liberatore, Eda Yildirim-Ayan
Summary: The study investigated the effects of the digestive inflammatory environment on scaffold degradation, prevention of premature degradation using genipin crosslinking, and how genipin crosslinking affects IL-4 release and differentiation of naive macrophages. The results showed that the digestive inflammatory environment led to increased protein release from the scaffold, which was improved through genipin crosslinking. The optimal genipin concentration improved IL-4 release, cell viability, mechanical strength, scaffold porosity, and immunomodulation studies, but also decreased the immunomodulatory capacity of the scaffold.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Amanda M. Peluzzo, Michael V. Autieri
Summary: Angiogenesis is a vital process for development, wound repair, and tissue perfusion. Inflammation and neovascularization are interconnected biological processes. Although pro-inflammatory factors drive angiogenesis, the role of anti-inflammatory interleukins in this process remains unclear.
Article
Biochemistry & Molecular Biology
Rogier A. Gaiser, Jaione Ayerra Mangado, Milena Mechkarska, Wendy E. Kaman, Peter van Baarlen, J. Michael Conlon, Jerry M. Wells
CHEMICAL BIOLOGY & DRUG DESIGN
(2020)
Article
Cell Biology
Galyna Graham, Andrew McCloskey, Yasser H. Abdel-Wahab, J. Michael Conlon, Peter R. Flatt
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2020)
Article
Oncology
Andra Jevtovic, Jelena Pantic, Ivan Jovanovic, Marija Milovanovic, Ivan Stanojevic, Danilo Vojvodic, Nebojsa Arsenijevic, Miodrag L. Lukic, Gordana D. Radosavljevic
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2020)
Article
Chemistry, Medicinal
Sasa Benazic, Zana Besser Silconi, Andra Jevtovic, Milena Jurisevic, Jelena Milovanovic, Marina Mijajlovic, Milos Nikolic, Tatjana Kanjevac, Ivan Potocnak, Erika Samolova, Zoran R. Ratkovic, Gordana Radic, Marija Milovanovic, Jelena Pantic, Nebojsa Arsenijevic, Gordana D. Radosavljevic
FUTURE MEDICINAL CHEMISTRY
(2020)
Article
Infectious Diseases
Gervonne Barran, Jolanta Kolodziejek, Laurent Coquet, Jerome Leprince, Thierry Jouenne, Norbert Nowotny, J. Michael Conlon, Milena Mechkarska
Article
Biochemistry & Molecular Biology
Galyna Graham, J. Michael Conlon, R. Charlotte Moffett, Yasser H. Abdel-Wahab, Peter R. Flatt
Summary: The study showed that long-acting, dual-agonist anti-diabetic peptides can induce alpha-cell to beta-cell transdifferentiation, leading to increased pancreatic insulin content and plasma insulin concentrations. This suggests therapeutic potential for using proglucagon-derived peptides from phylogenetical ancient fish in diabetes treatment.
JOURNAL OF PEPTIDE SCIENCE
(2021)
Review
Chemistry, Medicinal
Milica M. Borovcanin, Gordana D. Radosavljevic, Jelena Pantic, Jelena Milovanovic, Natasa R. Mijailovic, Aleksandar N. Arsenijevic, Nebojsa N. Arsenijevic
Summary: Gal-3 has been explored for its role in somatic diseases and neuroinflammation, leading to the possibility of its involvement in neuroprogression in schizophrenia. Its potential role in early life programming of schizophrenia, unique response to viral infections later in life, and somatic dysfunction leading to mental changes are also highlighted. This review aims to integrate these observations into understanding schizophrenia onset, clinical symptoms presentation, somatic comorbid states, and potential Gal-3 centered treatment options.
CURRENT TOPICS IN MEDICINAL CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
J. Michael Conlon, Finbarr P. M. O'Harte, Peter R. Flatt
Summary: Peptides derived from ancient fish, such as lamprey GLP-1 and paddlefish glucagon, act as naturally occurring dual agonists at GLP1R and GCPR receptors, showing potential in improving glucose tolerance, insulin sensitivity, and beta-cell proliferation. Studies suggest that these fish-derived peptides have therapeutic potential for obesity-related T2DM.
Article
Biochemistry & Molecular Biology
Zana Besser Silconi, Vesna Rosic, Sasa Benazic, Gordana Radosavljevic, Marina Mijajlovic, Jelena Pantic, Zoran R. Ratkovic, Gordana Radic, Aleksandar Arsenijevic, Marija Milovanovic, Nebojsa Arsenijevic, Jelena Milovanovic
Summary: The study demonstrates that PtCl2(S-pr-thiosal)2 exhibits antitumor activity against B cell malignancies by inhibiting cell proliferation, inducing apoptosis, and reducing phosphorylation of STAT3 and NF kappa B.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Psychiatry
Aleksandra Koricanac, Aleksandra Tomic Lucic, Mirjana Veselinovic, Danijela Bazic Sretenovic, Gorica Bucic, Anja Azanjac, Olivera Radmanovic, Mirjana Matovic, Marijana Stanojevic, Aleksandra Jurisic Skevin, Bojana Simovic Markovic, Jelena Pantic, Nebojsa Arsenijevic, Gordana D. Radosavljevic, Maja Nikolic, Nenad Zornic, Jelena Nesic, Nemanja Muric, Branimir Radmanovic
Summary: This study aimed to determine the risk of developing metabolic syndrome in patients diagnosed with schizophrenia and identify the factors that predispose them to it. Findings suggest that patients treated with risperidone and clozapine may be at higher risk for metabolic syndrome compared to patients treated with aripiprazole.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Biochemistry & Molecular Biology
J. Michael Conlon, Lauren Hunter, Samir Attoub, Bruno Casciaro, Milena Mechkarska, Yasser H. A. Abdel-Wahab
Summary: Ocellatin-3N is a peptide that inhibits the growth of various bacteria and pathogens, and has potential therapeutic effects. It also regulates insulin release and intracellular calcium ion concentration.
JOURNAL OF PEPTIDE SCIENCE
(2023)
Article
Infectious Diseases
J. Michael Conlon, Laure Guilhaudis, Samir Attoub, Laurent Coquet, Jerome Leprince, Thierry Jouenne, Milena Mechkarska
Summary: Peptidomic analysis of skin secretions from Boana boans frogs led to the isolation and structural characterization of five host-defense peptides with limited structural similarity to figainin 2 and picturin peptides. These peptides showed antimicrobial activity and cytotoxicity against human tumor-derived cells.
Article
Infectious Diseases
Milena Mechkarska, Taylor S. Cunning, Megan G. Taggart, Nigel G. Ternan, Jerome Leprince, Laurent Coquet, Thierry Jouenne, Jordi Tena-Garces, Juan J. Calvete, J. Michael Conlon
Summary: The venom of the Trinidad thick-tailed scorpion contains peptides with antimicrobial activity and potassium channel and sodium channel toxins. Among the peptides, TtAP-1 exhibits strong bactericidal activity against various bacteria and can rapidly kill clinically relevant bacteria. However, its high hemolytic activity limits its potential as an anti-infective agent.
Review
Biochemistry & Molecular Biology
Nasrin Abbasi Gharibkandi, J. Michael Conlon, Seyed Jalal Hosseinimehr
Article
Biochemistry & Molecular Biology
Siva Santhiya Arul, Brinda Balakrishnan, Savithri S. Handanahal, Sangita Venkataraman
Summary: Viral nanoparticles are self-assembling delivery systems used for vaccines and therapeutic agents. They have improved biocompatibility and are widely used in various biomedical applications. However, large-scale production of VNPs still faces challenges.
Article
Biochemistry & Molecular Biology
Wisely Chua, Carl O. Marsh, Si En Poh, Winston LC. Koh, Melody Li Ying Lee, Li Fang Koh, Xin-Zi Emily Tang, Peter See, Zheng Ser, Shi Mei Wang, Radoslaw M. Sobota, Thomas L. Dawson Jr, Yik Weng Yew, Steven Thng, Anthony J. O'Donoghue, Hazel H. Oon, John E. Common, Hao Li
Summary: In this study, the gene expression of enzymes secreted by Malassezia globosa in the skin was investigated using targeted RNA sequencing. The study found that the expression of these enzymes is regulated by the fungus's environment and differs significantly from healthy skin sites. Additionally, a pseudoprotease MGL_3331 was identified to elicit an immune reaction in patients with atopic dermatitis. This highlights the importance of studying fungal proteins in physiologically relevant environments and their role in host immunity.
Article
Biochemistry & Molecular Biology
Belisa Parmeggiani, Marian Flores Signori, Cristiane Cecatto, Marina Rocha Frusciante, Manuela Bianchin Marcuzzo, Debora Guerini Souza, Rafael Teixeira Ribeiro, Bianca Seminotti, Diogo Onofre Gomes de Souza, Cesar Augusto Joa o Ribeiro, Moacir Wajner, Guilhian Leipnitz
Summary: Non ketotic hyperglycinemia (NKH) is a disorder caused by mutations in the genes encoding glycine cleavage system proteins, leading to severe neurodegeneration and white matter alterations. The study found that glycine affects myelin structure, glutamatergic system, and induces oxidative stress in neonatal rats and MO3.13 oligodendroglial cells.
Review
Biochemistry & Molecular Biology
Marie Rose Ndella Thiaw, Pascal Gantet
Summary: Mini zinc fingers play important roles in plant development, including control of cell division and expansion, meristem state transition, and growth and organ development. They have diverse modes of action, such as direct gene activation, interaction with specific transcription factors, and aggregation of protein complexes for chromatin remodeling. Further research is needed to explore their wider range of biological functions and their involvement in biotic and abiotic stress responses.
Article
Biochemistry & Molecular Biology
Shao-Jui Lai, Takahiro Kameda, Maasa Morita, Yuka Yamagata, Kaoruko Nishizaka, Yuna Horiuchi, Yukihiro Kobayashi, Yoko Usami, Jun-Jen Liu, Takeshi Kasama, Minoru Tozuka, Ryunosuke Ohkawa
Summary: In this study, the co-modification and impact of chymase and MPO on HDL were investigated. Sequential treatment with MPO and chymase generated two novel apoA-I fragments from HDL, one of which has a specific immunological property and can be used to predict patients with normal HDL-C levels and cardiovascular diseases.
Article
Biochemistry & Molecular Biology
Xiao-Mi Sun, Asami Yoshida, Takuya Ishii, Yan-Rong Jiang, Yi-Li Gao, Mikinori Ueno, Katsuya Hirasaka, Kiyoshi Osatomi
Summary: This study found that infection with the causative bacteria of edwardsiellosis, Edwardsiella tarda NUF251, leads to the production of superoxide radicals, causing oxidative stress. The research on the Jfsod1 gene suggests that the transcription factor NF-IL6 plays a significant role in upregulating the transcriptional activity of the gene in response to oxidative stress induced by NUF251 infection.
Article
Biochemistry & Molecular Biology
Shane M. Carey, Sean P. Kearns, Matthew E. Millington, Gregory S. Buechner, Beda E. Alvarez Jr, Leily Daneshian, Brendan Abiskaroon, Maksymilian Chruszcz, Edward L. D'Antonio
Summary: The importance of F337 in TcGlcK was investigated using the hole mutagenesis approach, revealing its key interactions with aromatic tail groups in inhibitor molecules. Mutants retaining activity and structural similarity were obtained, suggesting the possibility of TcHxK existing as a monomer lacking the F337 residue. Similar D-glucosamine inhibitors may bind less strongly to TcHxK due to the absence of van der Waals contacts from residue side chains.
Article
Biochemistry & Molecular Biology
Catia Barria, Diogo Athayde, Guillem Hernandez, Leonor Fonseca, Jorge Casinhas, Tiago N. Cordeiro, Margarida Archer, Cecilia M. Arraiano, Jose A. Brito, Rute G. Matos
Summary: Ribonucleases play a crucial role in RNA regulation by processing, degrading, and quality controlling cellular transcripts. Campylobacter jejuni, the main cause of human gastroenteritis, relies on the exoribonuclease PNPase (CjPNP) for low-temperature survival, virulence factor synthesis, and swimming, cell adhesion/invasion, and chick colonization abilities. The crystallographic structure of CjPNP, along with SAXS analysis, confirms its trimeric arrangement and provides insight into domain arrangement and flexibility. Mutations in highly conserved residues reveal unexpected RNA degradation activity even under conditions favoring polymerization. These findings have significant implications for the development of strategies to combat C. jejuni infections.
Article
Biochemistry & Molecular Biology
Elvira R. Shaykhutdinova, Maria S. Severyukhina, Inna V. Kholoshenko, Elena A. Gondarenko, Irina V. Shelukhina, Elena V. Kryukova, Alina M. Ismailova, Elena S. Sadovnikova, Igor A. Dyachenko, Arkady N. Murashev, Victor I. Tsetlin, Yuri N. Utkin
Summary: Evidence suggests that activating nicotinic acetylcholine receptors (nAChRs) can reduce cardiac injury caused by ischemia and reperfusion. In this study, the expression of a4, a6, and a132 nAChR subunits in the rat heart's left ventricle was demonstrated. The nAChR agonists cytisine and varenicline, commonly used for nicotine addiction treatment, were found to significantly reduce myocardial ischemia-reperfusion injury, with varenicline showing greater protection. The presence of a4132, a7, and/or a6132-containing receptors suggests that the protective effect of varenicline may be mediated by these subunits. These findings indicate a potential new use for cytisine and varenicline as cardioprotective agents.
Article
Biochemistry & Molecular Biology
Xinhai Xiong, Wenjie Chen, Cheng Chen, Qi Wu, Chaopeng He
Summary: This article summarizes the important roles of Cx43 in disease development from the perspective of subcellular localization and provides new ideas for Cx43 as a therapeutic target and the search for related pathological mechanisms.
Article
Biochemistry & Molecular Biology
Veronica Bastos, Simone Pascoal, Kamila Lopes, Marcia Mortari, Helena Oliveira
Summary: Cancer, especially melanoma, is a major global health problem due to its metastatic capacity, treatment resistance, and high mortality rates. The Chartergellus-CP1 peptide isolated from Chartergellus communis wasp venom showed selective cytotoxicity towards melanoma cell lines, inducing apoptosis, cell cycle impairment, and intracellular ROS increase.
Article
Biochemistry & Molecular Biology
Charlotte Claeyssen, Nathan Bulangalire, Bruno Bastide, Onnik Agbulut, Caroline Cieniewski-Bernard
Summary: Maintenance of striated muscle tissue relies on a dynamic network of protein-protein interactions. Desmin intermediate filaments play a crucial role in heart and skeletal muscle by maintaining cell structure and contributing to various cellular processes. The assembly of desmin intermediate filaments requires aB-crystallin, which is involved in multiple cellular functions.
Article
Biochemistry & Molecular Biology
Dhritiman Dey, Adhiraj Dasgupta, Dipanjan Ghosh, Oindrila Bhattacharjee, Abhrajyoti Ghosh, Ayae Honda, Dhrubajyoti Chattopadhyay
Summary: This study successfully identified host factors that interact with Chandipura Virus (CHPV) and play a critical role in infection, including A2M, LRP1, and GRP78. Knocking out A2M has a severe effect on viral infection, indicating the potential role of these host proteins in viral entry into host cells.
Article
Biochemistry & Molecular Biology
Anna Dotsenko, Igor Sinelnikov, Aleksandra Rozhkova, Ivan Zorov, Arkady Sinitsyn
Summary: Xylanases play important roles in various industrial applications, such as feed additives, pulp and paper bleaching, and the production of bread, food, and drinks. Xylanases from the GH10 family show high thermostability and resistance to protein inhibitors, making them promising candidates for these processes. This study successfully improved the thermostability and enzymatic activity of GH10 xylanase, which could enhance its effectiveness as a feed additive and during pulp and paper bleaching.
Article
Biochemistry & Molecular Biology
M. Jaquet, M. Bengue, K. Lambert, G. Carnac, D. Misse, C. Bisbal
Summary: Changes to our environment have led to the emergence of human pathogens such as chikungunya virus, which is now a major public health concern. In this study, the interconnection between skeletal muscle cells metabolism, their differentiation stage, and the infectivity of chikungunya virus was investigated. The results showed that chikungunya virus infectivity is dependent on cell differentiation and metabolism and that the virus interferes with cellular metabolism.