Article
Multidisciplinary Sciences
Thomas D. Jackson, Jordan J. Crameri, Linden Muellner-Wong, Ann E. Frazier, Catherine S. Palmer, Luke E. Formosa, Daniella H. Hock, Kenji M. Fujihara, Tegan Stait, Alice J. Sharpe, David R. Thorburn, Michael T. Ryan, David A. Stroud, Diana Stojanovski
Summary: Sideroflexins (SFXNs) are a family of proteins that have different functions in mitochondrial biology. Loss of SFXN4 leads to complex I assembly defect and it interacts with the core components of the mitochondrial complex I intermediate assembly complex.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Plant Sciences
Jun Morishita, Ryutaro Tokutsu, Jun Minagawa, Toru Hisabori, Ken-ichi Wakabayashi
Summary: Researchers isolated seven mutants with positive phototaxis to study the ROS-dependent regulatory mechanism, suggesting that the regulation of phototactic sign is not a single pathway and is influenced by various cellular factors. Interestingly, five mutants showed faster growth rates than the wild type, indicating potential clues for efficient algae cultivation by analyzing mutants with defects in phototactic-sign regulation.
Article
Biochemistry & Molecular Biology
Bettina Homberg, Katharina Roempler, Mirjam Wissel, Sylvie Callegari, Markus Deckers
Summary: The respiratory chain in mitochondria consists of individual complexes and large supercomplex structures, which are dynamically regulated to adapt to environmental and metabolic changes. The Rcf protein family plays a crucial role in regulating the assembly and enzyme activity of complex IV within supercomplexes. Members of the Rcf family, such as Rcf1, Rcf2, and Rcf3, have specific functions in the assembly and enzymatic regulation processes.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Andreas Kohler, Antoni Barrientos, Flavia Fontanesi, Martin Ott
Summary: The mitochondrial respiratory chain is an important system for energy conversion in eukaryotic cells. The organization of respiratory chain complexes into supercomplexes provides advantages for cellular energy conversion, although its universality is still debated. Further research is needed to fully understand the functional significance of these supercomplexes.
Review
Biochemistry & Molecular Biology
Shuting Guan, Li Zhao, Ruiyun Peng
Summary: Mitochondrial supercomplexes, consisting of enzyme complexes and electron carriers, play a crucial role in improving the efficiency of mitochondrial respiratory chain and maintaining cellular metabolism homeostasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Fabian Dieter, Carsten Esselun, Gunter P. Eckert
Summary: Alpha lipoic acid (ALA) has strong antioxidant properties and can significantly improve mitochondrial dysfunction in a cellular model of Alzheimer's disease (AD). ALA increases the activity of respiratory chain complexes, enhances mitochondrial membrane potential (MMP) and ATP levels, leading to improved mitochondrial function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Food Science & Technology
Jun Wang, Xue Tang, Yipin Lu, Yingying Zheng, Fanhang Zeng, Wentao Shi, Peng Zhou
Summary: The study demonstrates that lycopene can alleviate myocardial dysfunction and energy metabolism issues induced by Dityrosine, by improving mitochondrial performance and reducing oxidative stress to enhance heart health.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Michele Brischigliaro, Alfredo Cabrera-Orefice, Mattia Sturlese, Dei M. Elurbe, Elena Frigo, Erika Fernandez-Vizarra, Stefano Moro, Martijn A. Huynen, Susanne Arnold, Carlo Viscomi, Massimo Zeviani
Summary: The composition of cytochrome c oxidase (COX) is functionally conserved between vertebrate and invertebrate species, despite potential differences in individual structures.
Article
Genetics & Heredity
Rocio Rius, Alison G. Compton, Naomi L. Baker, AnneMarie E. Welch, David Coman, Maina P. Kava, Andre E. Minoche, Mark J. Cowley, David R. Thorburn, John Christodoulou
Summary: Genome Sequencing (GS) can effectively identify variants in both nuclear and mitochondrial DNA, offering diagnostic advantages for mitochondrial diseases. With ongoing technical improvements and cost reductions, the routine diagnostic usage of GS is expected to expand in the field of mitochondrial diseases.
Article
Biochemistry & Molecular Biology
Audrey-Ann Dumont, Lauralyne Dumont, Delong Zhou, Hugo Giguere, Chantal Pileggi, Mary-Ellen Harper, Denis P. Blondin, Michelle S. Scott, Mannix Auger-Messier
Summary: The study demonstrates the importance of Srsf3 in maintaining mitochondrial integrity during cardiac development, with Srsf3 deletion leading to severe heart remodeling and cardiomyocyte enlargement.
Review
Biochemistry & Molecular Biology
Daniel Schniertshauer, Susanne Wespel, Joerg Bergemann
Summary: Based on the understanding that many diseases are caused by defects in cellular metabolism, especially in mitochondria, mitochondrial medicine aims to correct these dysfunctions. This form of therapy has gained significance in various fields of human medicine in recent years. It focuses on influencing disturbed cellular energy metabolism and the imbalanced antioxidant system of patients. Mitotropic substances, used as a primary tool, aim to compensate for existing dysfunction. The effectiveness of these substances and accompanying studies are summarized in this article, showing that their actions are based on antioxidative and enhanced mitochondrial respiratory chain properties.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Irene Hana Flones, Harald Nyland, Dagny-Ann Sandnes, Guido Werner Alves, Ole-Bjorn Tysnes, Charalampos Tzoulis
Summary: Early alpha-synuclein aggregation is associated with mitochondrial respiratory complex I (CI) deficiency in neurons of idiopathic Parkinson's disease (iPD), and there is selective loss of neurons affected by both pathologies.
Article
Environmental Sciences
Libing Yu, Wenjing Li, Jian Chu, Chun Chen, Xijian Li, Wei Tang, Binyuan Xia, Zhonghua Xiong
Summary: Uranium as an emerging pollutant presents serious threats to ecological and human health, with the kidney identified as a major deposition site and sensitive target organ for its toxicity, which is associated with oxidative stress and mitochondrial respiration. This study found that cytochrome c oxidase and ATP synthase play key roles in uranium-induced toxicity by inhibiting their activities in the mitochondrial respiration pathway. These inhibitory effects could explain the generation of reactive oxygen species and mitochondrial alterations observed in uranium poisoning.
ENVIRONMENTAL POLLUTION
(2021)
Article
Biochemistry & Molecular Biology
Erika Fernandez-Vizarra, Sandra Lopez-Calcerrada, Luke E. Formosa, Rafael Perez-Perez, Shujing Ding, Ian M. Fearnley, Joaquin Arenas, Miguel A. Martin, Massimo Zeviani, Michael T. Ryan, Cristina Ugalde
Summary: The study of mitochondrial respiratory chain function in relation to its structural organization is essential for understanding eukaryotic cell metabolism. The complexome profiling technique has provided valuable information on the composition and assembly of MRC complexes, including larger supercomplexes and respirasomes. SCAFI plays a role in connecting individual MRC complexes III and IV, but is not the main player in respirasome formation as previously thought.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
(2021)
Article
Cell Biology
Sanna Ryytty, Shalem R. Modi, Nikolay Naumenko, Anastasia Shakirzyanova, Muhammad Obaidur Rahman, Miia Vaara, Anu Suomalainen, Pasi Tavi, Riikka H. Hamalainen
Summary: The m.3243A>G mutation in mitochondrial tRNA-Leu(UUR) is a common pathogenic mutation in humans, but the causes for the clinical variability are unknown. In this study, iPSC-CMs derived from two different m.3243A>G patients were used to investigate the molecular effects of high mutation load on cardiomyocyte functionality. The results showed that high mutation load impaired mitochondrial respiration in both patients' cells, but the downstream consequences varied, suggesting the influence of other factors such as glucose metabolism, ATP levels, and intracellular calcium signaling.
Review
Biochemistry & Molecular Biology
Jonathan Przybyla-Toscano, Jeremy Couturier, Claire Remacle, Nicolas Rouhier
Summary: Iron-containing proteins, such as Fe-S proteins, are crucial for electron transfer and metabolic reactions in cells. They play important roles in various pathways in plastids, including photosynthesis, carbon assimilation, and synthesis of essential compounds like chlorophyll.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Correction
Biophysics
H. V. Miranda-Astudillo, K. N. S. Yadav, E. J. Boekema, P. Cardol
JOURNAL OF BIOENERGETICS AND BIOMEMBRANES
(2021)
Review
Plant Sciences
Su Yin Phua, Barbara De Smet, Claire Remacle, Kai Xun Chan, Frank Van Breusegem
Summary: The evolution of photosynthesis in plants has been crucial but has also led to challenges in the form of reactive oxygen species (ROS) production. Multiple forms of ROS are generated in various plant cell compartments, requiring a sophisticated network of ROS detoxification and signaling tailored to individual organelles to safeguard the cell as a whole.
JOURNAL OF EXPERIMENTAL BOTANY
(2021)
Article
Plant Sciences
Gilles Curien, Dagmar Lyska, Erika Guglielmino, Phillip Westhoff, Janina Janetzko, Marianne Tardif, Clement Hallopeau, Sabine Brugiere, Davide Dal Bo, Johan Decelle, Benoit Gallet, Denis Falconet, Michele Carone, Claire Remacle, Myriam Ferro, Andreas P. M. Weber, Giovanni Finazzi
Summary: It has been shown that G. sulphuraria can grow under different nutritional modes; under mixotrophic conditions, the addition of organic carbon can alleviate the inorganic carbon limitation in photosynthesis.
Article
Plant Sciences
Gwenaelle Gain, Felix Vega de Luna, Javier Cordoba, Emilie Perez, Herve Degand, Pierre Morsomme, Marc Thiry, Denis Baurain, Mattia Pierangelini, Pierre Cardol
Summary: The study found that there is photosynthesis-respiration coupling and membrane contacts between mitochondria and chloroplasts in E. gracilis. However, in mixotrophy, adjustment of the chloroplast ATP/NADPH ratio drives the interaction, while in photoautotrophy, the coupling is conditioned by CO2 limitation and photorespiration. Maintenance of photosynthesis-respiration coupling through plastic metabolic responses is key to E. gracilis functioning under changing environmental conditions.
Article
Genetics & Heredity
Javier Cordoba, Emilie Perez, Mick Van Vlierberghe, Amandine R. Bertrand, Valerian Lupo, Pierre Cardol, Denis Baurain
Summary: Euglena gracilis, a photosynthetic microeukaryote, has a complex gene ancestry and gene regulation in euglenozoans is not primarily controlled at the transcriptional level, as revealed in transcriptome analysis. The evolutionary history of E. gracilis involves a convoluted process with more than two partners, ruling out sequence contamination as a possible explanation for the mixed gene ancestry observed.
Article
Chemistry, Analytical
Alain Gervasi, Pierre Cardol, Patrick E. Meyer
Summary: Bright field microscopes are useful tools for biologists to observe and analyze cells. Researchers have developed a stand-alone microscope that can automatically collect samples and capture images using computer vision algorithms.
Article
Biology
Amelie Corato, Thanh Tung Le, Denis Baurain, Philippe Jacques, Claire Remacle, Fabrice Franck
Summary: A new strain from the genus Coelastrella was isolated in this study, which showed rapid growth in phototrophy and accumulated astaxanthin, canthaxanthin, and fatty acids under nitrogen depletion conditions, suggesting its potential application in biorefinery.
Review
Plant Sciences
Michael Schroda, Claire Remacle
Summary: Chlamydomonas reinhardtii has emerged as a production platform for biotechnology purposes due to significant advancements in nuclear transgene expression, synthetic biology strategies, and genome editing using CRISPR/Cas9. These developments have established Chlamydomonas as an ideal chassis for synthetic biology and offer the potential to rewire its metabolism for new capabilities.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Agricultural Engineering
Sergio Martinez-Villarreal, Antoine Breitenstein, Philippe Nimmegeers, Pablo Perez Saura, Bingxin Hai, Justice Asomaning, Ali Alizadeh Eslami, Pieter Billen, Steven Van Passel, David C. Bressler, Damien P. Debecker, Claire Remacle, Aurore Richel
Summary: In the process of transitioning towards carbon-neutral economies, the aviation sector is a key contributor to greenhouse gas emissions due to its dependence on fossil fuels. As an alternative, biofuels derived from microalgae are being developed due to their potential for lipid accumulation. This review discusses the development status, opportunities, and challenges of technologies that can transform microalgae into aviation fuels, along with an assessment of the present techno-economic feasibility. Further developments are needed to reduce the costs and improve the overall economics of microalgae cultivation and harvesting.
BIOMASS & BIOENERGY
(2022)
Article
Plant Sciences
Pablo Perez Saura, Malika Chabi, Amelie Corato, Pierre Cardol, Claire Remacle
Summary: The study found that there was no significant difference in the biomass, fatty acid composition, protein, and storage carbohydrate contents of the extremophilic red microalga Galdieria sulphuraria 074W when grown in heterotrophy compared to photoautotrophic condiitons. However, the presence of glucose resulted in a decrease in pigment content, while the presence of glycerol did not. Transcriptome analysis revealed the transcriptional response of the cells to light and dark environments, as well as the involvement of horizontally transferred gene families in response to the availability of different organic and inorganic sources.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Marine & Freshwater Biology
Stephane Roberty, Felix Vega de Luna, Mattia Pierangelini, Julie Bomhals, Jean-Christophe Plumier, Oren Levy, Pierre Cardol
Summary: The study compared the use of photosynthetic alternative electron flows (AEFs) in shallow and mesophotic colonies of Stylophora pistillata coral and evaluated the plasticity of photosynthesis under light stress. The results showed that both coral types were able to efficiently utilize photosynthetically derived electrons, but mesophotic colonies had lower capacity for dissipating light energy under high light intensity, leading to strong photoinhibition. This study highlights the importance of photosynthetic alternative electron flows in coral's acclimation to light and how the plasticity of photosynthetic processes in Symbiodiniaceae may shape the vertical distribution of corals.
Article
Plant Sciences
Sara M. Esteves, Alice Jadoul, Fabrizio Iacono, Marie Schloesser, Bernard Bosman, Monique Carnol, Tom Druet, Pierre Cardol, Marc Hanikenne
Summary: This study reveals extensive genetic variation in Chlamydomonas reinhardtii and describes how this variation influences the response to nutrient deficiency, with a focus on differences between natural and laboratory strains.
JOURNAL OF EXPERIMENTAL BOTANY
(2023)
Article
Multidisciplinary Sciences
Xiaojie Pang, Wojciech J. Nawrocki, Pierre Cardol, Mengyuan Zheng, Jingjing Jiang, Yuan Fang, Wenqiang Yang, Roberta Croce, Lijin Tian
Summary: Weak acids produced during fermentation can suppress both photosynthesis and aerobic respiration. This effect is widespread among photosynthetic organisms and helps algae adapt to changing environmental conditions.
NATURE COMMUNICATIONS
(2023)
Article
Plant Sciences
Stanislas Thiriet-Rupert, Gwenaelle Gain, Alice Jadoul, Amandine Vigneron, Bernard Bosman, Monique Carnol, Patrick Motte, Pierre Cardol, Cecile Nouet, Marc Hanikenne
Summary: The study found that the green algae's response to cadmium toxicity is influenced by both short-term and long-term exposure, but biomass production can recover to levels similar to control conditions after long-term acclimation. This recovery involves changes in cell wall-related gene expression, dynamics of metal ion uptake and homeostasis, photosynthesis efficiency, and adjustment through metal homeostasis. It also identified the coordination of phosphorus and iron homeostasis mediated by specific regulators as key factors in the algae's physiological plasticity.
Article
Biochemistry & Molecular Biology
Siva Santhiya Arul, Brinda Balakrishnan, Savithri S. Handanahal, Sangita Venkataraman
Summary: Viral nanoparticles are self-assembling delivery systems used for vaccines and therapeutic agents. They have improved biocompatibility and are widely used in various biomedical applications. However, large-scale production of VNPs still faces challenges.
Article
Biochemistry & Molecular Biology
Wisely Chua, Carl O. Marsh, Si En Poh, Winston LC. Koh, Melody Li Ying Lee, Li Fang Koh, Xin-Zi Emily Tang, Peter See, Zheng Ser, Shi Mei Wang, Radoslaw M. Sobota, Thomas L. Dawson Jr, Yik Weng Yew, Steven Thng, Anthony J. O'Donoghue, Hazel H. Oon, John E. Common, Hao Li
Summary: In this study, the gene expression of enzymes secreted by Malassezia globosa in the skin was investigated using targeted RNA sequencing. The study found that the expression of these enzymes is regulated by the fungus's environment and differs significantly from healthy skin sites. Additionally, a pseudoprotease MGL_3331 was identified to elicit an immune reaction in patients with atopic dermatitis. This highlights the importance of studying fungal proteins in physiologically relevant environments and their role in host immunity.
Article
Biochemistry & Molecular Biology
Belisa Parmeggiani, Marian Flores Signori, Cristiane Cecatto, Marina Rocha Frusciante, Manuela Bianchin Marcuzzo, Debora Guerini Souza, Rafael Teixeira Ribeiro, Bianca Seminotti, Diogo Onofre Gomes de Souza, Cesar Augusto Joa o Ribeiro, Moacir Wajner, Guilhian Leipnitz
Summary: Non ketotic hyperglycinemia (NKH) is a disorder caused by mutations in the genes encoding glycine cleavage system proteins, leading to severe neurodegeneration and white matter alterations. The study found that glycine affects myelin structure, glutamatergic system, and induces oxidative stress in neonatal rats and MO3.13 oligodendroglial cells.
Review
Biochemistry & Molecular Biology
Marie Rose Ndella Thiaw, Pascal Gantet
Summary: Mini zinc fingers play important roles in plant development, including control of cell division and expansion, meristem state transition, and growth and organ development. They have diverse modes of action, such as direct gene activation, interaction with specific transcription factors, and aggregation of protein complexes for chromatin remodeling. Further research is needed to explore their wider range of biological functions and their involvement in biotic and abiotic stress responses.
Article
Biochemistry & Molecular Biology
Shao-Jui Lai, Takahiro Kameda, Maasa Morita, Yuka Yamagata, Kaoruko Nishizaka, Yuna Horiuchi, Yukihiro Kobayashi, Yoko Usami, Jun-Jen Liu, Takeshi Kasama, Minoru Tozuka, Ryunosuke Ohkawa
Summary: In this study, the co-modification and impact of chymase and MPO on HDL were investigated. Sequential treatment with MPO and chymase generated two novel apoA-I fragments from HDL, one of which has a specific immunological property and can be used to predict patients with normal HDL-C levels and cardiovascular diseases.
Article
Biochemistry & Molecular Biology
Xiao-Mi Sun, Asami Yoshida, Takuya Ishii, Yan-Rong Jiang, Yi-Li Gao, Mikinori Ueno, Katsuya Hirasaka, Kiyoshi Osatomi
Summary: This study found that infection with the causative bacteria of edwardsiellosis, Edwardsiella tarda NUF251, leads to the production of superoxide radicals, causing oxidative stress. The research on the Jfsod1 gene suggests that the transcription factor NF-IL6 plays a significant role in upregulating the transcriptional activity of the gene in response to oxidative stress induced by NUF251 infection.
Article
Biochemistry & Molecular Biology
Shane M. Carey, Sean P. Kearns, Matthew E. Millington, Gregory S. Buechner, Beda E. Alvarez Jr, Leily Daneshian, Brendan Abiskaroon, Maksymilian Chruszcz, Edward L. D'Antonio
Summary: The importance of F337 in TcGlcK was investigated using the hole mutagenesis approach, revealing its key interactions with aromatic tail groups in inhibitor molecules. Mutants retaining activity and structural similarity were obtained, suggesting the possibility of TcHxK existing as a monomer lacking the F337 residue. Similar D-glucosamine inhibitors may bind less strongly to TcHxK due to the absence of van der Waals contacts from residue side chains.
Article
Biochemistry & Molecular Biology
Catia Barria, Diogo Athayde, Guillem Hernandez, Leonor Fonseca, Jorge Casinhas, Tiago N. Cordeiro, Margarida Archer, Cecilia M. Arraiano, Jose A. Brito, Rute G. Matos
Summary: Ribonucleases play a crucial role in RNA regulation by processing, degrading, and quality controlling cellular transcripts. Campylobacter jejuni, the main cause of human gastroenteritis, relies on the exoribonuclease PNPase (CjPNP) for low-temperature survival, virulence factor synthesis, and swimming, cell adhesion/invasion, and chick colonization abilities. The crystallographic structure of CjPNP, along with SAXS analysis, confirms its trimeric arrangement and provides insight into domain arrangement and flexibility. Mutations in highly conserved residues reveal unexpected RNA degradation activity even under conditions favoring polymerization. These findings have significant implications for the development of strategies to combat C. jejuni infections.
Article
Biochemistry & Molecular Biology
Elvira R. Shaykhutdinova, Maria S. Severyukhina, Inna V. Kholoshenko, Elena A. Gondarenko, Irina V. Shelukhina, Elena V. Kryukova, Alina M. Ismailova, Elena S. Sadovnikova, Igor A. Dyachenko, Arkady N. Murashev, Victor I. Tsetlin, Yuri N. Utkin
Summary: Evidence suggests that activating nicotinic acetylcholine receptors (nAChRs) can reduce cardiac injury caused by ischemia and reperfusion. In this study, the expression of a4, a6, and a132 nAChR subunits in the rat heart's left ventricle was demonstrated. The nAChR agonists cytisine and varenicline, commonly used for nicotine addiction treatment, were found to significantly reduce myocardial ischemia-reperfusion injury, with varenicline showing greater protection. The presence of a4132, a7, and/or a6132-containing receptors suggests that the protective effect of varenicline may be mediated by these subunits. These findings indicate a potential new use for cytisine and varenicline as cardioprotective agents.
Article
Biochemistry & Molecular Biology
Xinhai Xiong, Wenjie Chen, Cheng Chen, Qi Wu, Chaopeng He
Summary: This article summarizes the important roles of Cx43 in disease development from the perspective of subcellular localization and provides new ideas for Cx43 as a therapeutic target and the search for related pathological mechanisms.
Article
Biochemistry & Molecular Biology
Veronica Bastos, Simone Pascoal, Kamila Lopes, Marcia Mortari, Helena Oliveira
Summary: Cancer, especially melanoma, is a major global health problem due to its metastatic capacity, treatment resistance, and high mortality rates. The Chartergellus-CP1 peptide isolated from Chartergellus communis wasp venom showed selective cytotoxicity towards melanoma cell lines, inducing apoptosis, cell cycle impairment, and intracellular ROS increase.
Article
Biochemistry & Molecular Biology
Charlotte Claeyssen, Nathan Bulangalire, Bruno Bastide, Onnik Agbulut, Caroline Cieniewski-Bernard
Summary: Maintenance of striated muscle tissue relies on a dynamic network of protein-protein interactions. Desmin intermediate filaments play a crucial role in heart and skeletal muscle by maintaining cell structure and contributing to various cellular processes. The assembly of desmin intermediate filaments requires aB-crystallin, which is involved in multiple cellular functions.
Article
Biochemistry & Molecular Biology
Dhritiman Dey, Adhiraj Dasgupta, Dipanjan Ghosh, Oindrila Bhattacharjee, Abhrajyoti Ghosh, Ayae Honda, Dhrubajyoti Chattopadhyay
Summary: This study successfully identified host factors that interact with Chandipura Virus (CHPV) and play a critical role in infection, including A2M, LRP1, and GRP78. Knocking out A2M has a severe effect on viral infection, indicating the potential role of these host proteins in viral entry into host cells.
Article
Biochemistry & Molecular Biology
Anna Dotsenko, Igor Sinelnikov, Aleksandra Rozhkova, Ivan Zorov, Arkady Sinitsyn
Summary: Xylanases play important roles in various industrial applications, such as feed additives, pulp and paper bleaching, and the production of bread, food, and drinks. Xylanases from the GH10 family show high thermostability and resistance to protein inhibitors, making them promising candidates for these processes. This study successfully improved the thermostability and enzymatic activity of GH10 xylanase, which could enhance its effectiveness as a feed additive and during pulp and paper bleaching.
Article
Biochemistry & Molecular Biology
M. Jaquet, M. Bengue, K. Lambert, G. Carnac, D. Misse, C. Bisbal
Summary: Changes to our environment have led to the emergence of human pathogens such as chikungunya virus, which is now a major public health concern. In this study, the interconnection between skeletal muscle cells metabolism, their differentiation stage, and the infectivity of chikungunya virus was investigated. The results showed that chikungunya virus infectivity is dependent on cell differentiation and metabolism and that the virus interferes with cellular metabolism.