期刊
BIOCHIMIE
卷 93, 期 12, 页码 2102-2111出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biochi.2011.06.032
关键词
Calcium signaling; Neural induction; Early neural development; Stem cell; Neural progenitor; Neuro-glial switch
资金
- CNRS (Centre National de la Recherche Scientifique)
- GDRE
- Procore/Ministere des Affaires Etrangeres/RGC (Hong Kong, PRC)
The calcium (Ca2+) signaling pathways have crucial roles in development from fertilization through differentiation to organogenesis. In the nervous system, Ca2+ signals are important regulators for various neuronal functions, including formation and maturation of neuronal circuits and long-term memory. However, Ca2+ signals are mainly involved in the earliest steps of nervous system development including neural induction, differentiation of neural progenitors into neurons, and the neuro-glial switch. This review examines when and how Ca2+ signals are generated during each of these steps with examples taken from in vivo studies in vertebrate embryos and from in vitro assays using embryonic and neural stem cells. Also discussed is the highly specific nature of the Ca2+ signaling pathway and its interaction with the other signaling pathways involved in early neural development. (C) 2011 Elsevier Masson SAS. All rights reserved.
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