期刊
BIOCHIMIE
卷 93, 期 11, 页码 2019-2023出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biochi.2011.07.023
关键词
Dual RNAs; RNA secondary structures; Coding sequence; RNAz; RNAcode
资金
- Deutsche Forschungsgemeinschaft [STA 850/7-1, SPP-1258]
Functional RNA elements can be embedded also within exonic sequences coding for functional proteins. While not uncommon in viruses, only a few examples of this type have been described in some detail for eukaryotic genomes. Here we use RNAz and RNAcode, two comparative genomics methods that measure signatures of stabilizing selection acting on RNA secondary structure and peptide sequence, resp., to survey the fruit fly genomes. We estimate that there might be on the order of 1000 loci that are subject to dual selection pressure. The used genome-wide screens also expose the limitations of the currently available methods. (C) 2011 Elsevier Masson SAS. All rights reserved.
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